What are the relevant clinical determinants to evaluate the results of rehabilitation after cerebral infarction.
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Biomedical subjects
Publications and source records attributed to G Weimann.
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Although the possibilities of physical methods and the active principles of physical medicine can only used to a very modest and small extent in the treatment of lymphatic edemas, they are nevertheless some of the few approaches to helping patients with such disorders effectively. As in so many chronic diseases, we must first of all restrict ourselves to assiduous and consistent control of functional disorders in order to improve them and perhaps occasionally eliminate them in mild cases. The active principle is the control of function!
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Two inhibitors of lactate dehydrogenase generated during NADH storage have been isolated by chromatography. One is a dimer of the dinucleotide where the AMP moiety is unmodified. The other is also generated from NAD+ in the presence of a high concentration of phosphate ions at alkaline pH. This inhibitor was proved to be the addition compound of one phosphate group to position C-4 of the nicotinamide ring of NAD+ by NMR spectroscopy, enzymatic cleavage, and dissociation to NAD+ at neutral pH. This compound is a competitive inhibitor with respect to NAD+ in the presence of the lactate dehydrogenase with a Ki of 2 X 10(-7) M. The interaction of this inhibitor with lactate dehydrogenase is discussed relative to the structure of this enzyme.
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