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Biomedical subjects

G Weber

Publications and source records attributed to G Weber.

At least 613 records · Page 34Linked to original sources
PubMed1980

[Therapy of salmonella enteritis with special reference to lactulose (author's transl)].

Excretion of Salmonellae in two groups of outpatients with Salmonellae is discussed. In one group of 51 adults, a total of 30 different serotypes were isolated. These patients were treated with lactulose and after four weeks the organisms had been eliminated in 68.6%. In a group of 23 adults receiving no treatment whatsoever, 56.5% were still excreting the organism after four weeks. Of the 64 in-patients studied, 37 received various antibiotics, 14 lactulose and in 13 only the symptoms were treated. The length of the excretion period was longer for the group receiving antibiotics (four weeks after onset of illness 67.8% were still excreting the organism). Treatment with lactulose, however, resulted in a shorter period of excretion for these patients. Special aspects of the various groups - e.g. age structure, pattern of infecting organisms - are reported in detail.

Adult↗
PubMed1979

Synthesis and spectral properties of a hydrophobic fluorescent probe: 6-propionyl-2-(dimethylamino)naphthalene.

Environmentally sensitive fluorescent probes involve two groups, an electron donor and an electron acceptor, attached to an aromatic ring system, and maximal effects may be expected when these groups are as far apart as feasible. The syntheisis, characterization, and spectroscopic properties of 6-propionyl-2-(dimethylamino)naphthalene (PRODAN), a compound that fulfills these conditions, are described. The maximum of emission is at 401 nm in cyclohexane solution and at 531 nm in water solution, indicating an increase of dipole moment of approximately 20 D units on excitation to the lowest singlet state. The effect of temperature upon the spectral distribution and the bandwidth of fluorescence of PRODAN in 1:1 complexes with albumin shows the existence of a dynamic relaxation process of the protein surroundings within th 2-4 ns of the fluorescence lifetime.

2-Naphthylamine↗
PubMed1979

[A computer-controlled monitoring and therapy system for shock compensation in severe burns (author's transl)].

A computer-controlled control loop for the automatic diagnosis of shock and infusion therapy is reported. External information (off-line) and vital parameters measured with serial devices (on-line) are used by the computer for the automatic control of infusion pumps. By this method the critical shock phase could be prevented in five seriously burned patients. The construction of the system also permits its use in other shock conditions.

Blood Pressure↗
PubMed1979

Neoplastic transformation-linked alterations in arginyl-tRNA synthetase activity.

The behavior of the activity of arginyl-tRNA synthetase (L-arginine : tRNAArg Ligase(AMP-forming), EC 6.1.1.19) was determined in extracts of rat liver: normal adult, normal proliferating (from developing and from partially hepatectomized rats), and neoplastic (hepatomas of different growth rates) and in extracts of rat kidney cortex and transplantable kidney tumors. The Km values for arginine, ATP, and tRNA of the enzyme of the rapidly growing hepatoma 3924A were the same as those of the enzyme from the liver of control rats. The pH optima of the control and neoplastic livers were in the same range of 7.25-8.0. Taking the hepatic specific activity for arginyl-tRNA synthetase as 100%, deep layer of gut, thymus and testis had higher activity; renal cortex and spleen had the same activity; and skeletal muscle, brain, heart, lung, superficial layer of gut and adipose tissue had lower activity. In a wide spectrum of hepatomas of different growth rates, a significant increase of 1.4-2.4-fold in arginyl-tRNA synthetase activity was observed when compared with that of liver of control normal rats. This elevation in enzyme activity in hepatomas appears to be specific to neoplasia, since it is unaltered in regenerating and low in differentiating liver. The increase in arginyl-tRNA synthetase in the liver tumors appears to be transformation-linked, since the activity was increased in all hepatomas, even in the slowest growing ones. Furthermore, the increase in enzyme activity was not limited to hepatic neoplasms, since a rise was also observed in transplantable rat kidney tumors. Thus, the reprogramming of gene expression in neoplastic tissue entails an increase in arginine-tRNA synthetase activity.

Aging↗
PubMed1979

Local and systemic changes of acid proteinases during advanced stages of burn injuries.

Rats were subjected to burns extending to 15% of their body surface. Enzyme activities were measured by a slightly modified Barrett technique between the 12th and 18th day after the burn injury. A statistically significant activation of acid proteolytic enzymes, in relation to mg protein, was seen in liver, spleen, kidney and stomach. In relation to grams fresh weight, an activation was seen in the kidney. Necrotic skin subsequent to burn injury showed a marked rise in activation compared with the skin of the control group, as well as with the skin of the burned animals. Increased enzyme contents were also detected in the intact skin of burned animals, compared with the skin of the control group.

Animals↗
PubMed1979

[Hydrotherapy pools, microbiological and chemical results (author's transl)].

The results of microbiological and chemical examinations of water samples collected from hydrotherapy pools for non incontinent patients proved that the officially agreed parameters for the surveillance of public swimming pools (Osterr. Bäderhygiene-Gesetz and Verordnung) have to be extended to meet the requirements of epidemiology. Similarly the requirements for treatment and operating conditions of those waters should be more rigorous. Minimal requirements for the treatment of water in hydrotherapy pools are recommended. The results of the study indicated also that the microbicide action of chlorine (chlorine gas, hypochlorite solution) was superior to those of DIHALO (chlorine-bromine-hydantoine). Suggestions are made for proper handling of waters which would lose their therapeutical potencies by any kind of treatment.

Baths↗