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Biomedical subjects

G Wauters

Publications and source records attributed to G Wauters.

At least 109 records · Page 6Linked to original sources
PubMed1983

[New bacteriologic aspects in infectious pathology].

Bacterial infectious pathology presents a series of new features which have been elucidated over the last few decades. These new aspects are derived from various factors: a development of our state of knowledge, a change in the ecology of a number of bacteria and a change in the receptiveness of patients. Modern infectious pathology is characterized by one particular feature: it is more and more difficult to define the limits between pathogenic and non-pathogenic bacteria; the role played by the host is of utmost importance.

Bacterial Infections↗
PubMed1982

[Pathogenesis of post-irradiation infection. 2. Role of polynucleated neutrophils in the defense of irradiated rats against Yersinia enterocolitica].

Wistar R inbred rats showed a substantial mortality when they were given Yersinia enterocolitica eight days after a 6.5 Gy total body irradiation. The possibility to abolish the high susceptibility of these irradiated rats to Yersinia enterocolitica by intravenous injections of isogenic neutrophils is presented: irradiated rats injected with 7 to 10.10(7) isogenic neutrophils, by the intravenous route, just before or after the administration of Yersinia enterocolitica, were not susceptible. On the contrary, control irradiated rats, not transfused, were killed by the same bacterial challenge.

Animals↗
PubMed1981

Pathogenesis of post-irradiation infections. I. Yersinia enterocolitica administered to normal and irradiated rats.

Infections after irradiation can be due to a great variety of microorganisms many of which are normally non-pathogenic or conditionally pathogenic for the host. The strain of Y. enterocolitica used was not pathogenic to a variety of unirradiated rats nor to athymic or B lymphocyte deprived, macrophage depleted rats, nor to normal rats irradiated by 5.7 Gy 24 hours before. However similarly irradiated rats receiving Y. enterocolitica 5 to 10 days later showed a substantial mortality. It is concluded that the radiosensitive mechanism for protection against Y. enterocolitica is not humoral nor cellular immunity as mediated by T and B lymphocytes or macrophages.

Animals↗
PubMed1981

Capsular typing of klebsiellae by coagglutination and latex agglutination.

A simple method for capsular serotype determination of Klebsiella is described, using staphylococci or latex particles coated by specific antibodies and the supernatant of a bacterial suspension in saline as antigen. These methods may be at least as reliable as other methods and easier to perform and less expensive than other methods.

Agglutination Tests↗
PubMed1981

Plasmid-encoded lysine decarboxylation in Proteus morganii.

As a rule, Proteus morganii does not decarboxylate lysine. However, lysine-positive P. morganii strains have been recently described. We suspected a plasmid origin for this atypical character, and we analyzed 14 strains to study this question. Among these strains, 8 yielded lysine-negative segregants after acridine orange or ethidium bromide treatment, and 10 transferred their lysine-positive character to a recipient P. morganii strain. All of the 14 strains analyzed at least segregated or conjugated. Three lysine-positive transconjugants, in turn, segregated lysine-negative variants after ethidium bromide treatment. The eight wild-type lysine-positive strains that segregated lysine-negative subclones contained a large (35 to 45 megadaltons) plasmid detectable by agarose gel electrophoresis. Similarly, the 10 lysine-positive transconjugants contained a plasmid of the same size, whereas P. morganii 1000, the recipient strain, did not contain any detectable plasmid. The large plasmid clearly disappeared in 9 of 11 lysine-negative segregants analyzed. It is concluded that the lysine-positive character of these P. morganii strains is plasmid encoded, and the taxonomical implications are discussed.

Carboxy-Lyases↗
PubMed1981

Yersinia enterocolitica: its isolation by cold enrichment from patients and healthy subjects.

Routine culture and cold enrichment were compared in a prospective study on the isolation of Yersinia enterocolitica from patients with intestinal disease. Healthy controls were examined with the cold enrichment method only. Y enterocolitica was isolated from 5.9% of 1635 patient stools, 3.4% of 206 appendices, and 4.0% of 555 control stools. Serotypes 0:3 and 0:9 were eight times more prevalent in patients than in controls. Other serotypes were twice as prevalent in controls than in patients. Cold enrichment did not significantly increase the recovery of serotypes 0:3 and 0:9 in acute enteritis, but it was responsible for all isolates of the other serotypes. Evidence is presented that the other serotypes are not pathogenic. In patient stools, Y enterocolitica was demonstrated less frequently than Salmonella (9.1%), and more often than Campylobacter jejuni (1.8%) and Shigella (0.1%).

Adolescent↗
PubMed1981

Cefotaxime kinetics after multiple-dose intramuscular study in healthy volunteers.

The pharmacokinetics of cefotaxime after repeated doses of intramuscular injections were studied in 8 healthy volunteers receiving 1 g cefotaxime every 8 h for 6 days. Mean peak serum level after the first 1 g intramuscular dose was 26.8 +/- 6.4 micrograms/ml and the peak serum concentration was reached within 75 min. The half-life of cefotaxime was 1.35 +/- 0.33 h and the total apparent clearance 263 +/- 63 ml/min. After the last injection (day 6), the mean peak serum level reached 19.1 +/- 3.2 micrograms/ml and the areas under the curve were significantly lower than on day 1. No body accumulation of the drug could be detected. Serum levels of cefotaxime monitored throughout the study 5 min prior to and 30 min after the intramuscular injection were found above the minimum inhibitory concentration for most aerobic gram-positive and gram-negative sensitive organisms.

Adult↗
PubMed1981

[The 'lost' intra-uterine contraceptive device (author's transl)].

The authors report five cases of lost intra-uterine devices, which means that the threads were not visible at the external os of the cervix. This gives them an opportunity to review the literature and to conclude the following: 1. Ultra-sound is the treatment of choice to find the position of the IUD that has been lost, whether is is intra- or extra-uterine. 2. In doubtful cases an antero-posterior and a lateral hysterogram makes it possible to determine the relative position of the IUD to the uterine cavity. Laparoscopy gives useful complementary information. 3. If the IUD is intra-uterine, either totally so or partially, the treatment of choice is to remove it under hysteroscopic control. 4. Where perforation has occurred and the IUD has only entered incompletely into the pelvis, it is possible to pull it out under hysteroscopic control through the vagina if laparoscopy has demonstrated that there are no local adhesions attaching it to neighbouring organs. 5. Where perforation has been complete, laparotomy is preferable to laparoscopy as a technique to recover the lost IUD, in particular when this is a copper one. 6. Perforations occur particularly when the IUDs are inserted post-partum.

Adult↗