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Biomedical subjects

G Walters

Publications and source records attributed to G Walters.

68 records · Page 4Linked to original sources
PubMed1975

Serum copper and caeruloplasmin in ankylosing spondylitis, systemic sclerosis, and morphea.

Studies of serum copper and caeruloplasmin were performed in patients with ankylosing spondylitis, systemic sclerosis, and morphea. Mean levels of both were raised significantly in ankylosing spondylitis, with the greatest increases in the worst cases. In patients with systemic sclerosis there was a significant increase in the mean level of caeruloplasmin, but not of copper, although both were raised in the 2 patients with the most aggressive disease. No alterations were found in patients with morphea. The values in the patients overlapped considerably with the values in the control subjects. It is thought that the increase in serum copper is probably secondary to the increase in caeruloplasmin which occurs as a nonspecific response to inflammation.

Ceruloplasmin↗
PubMed1975

Efficacy studies with three formulations of cambendazole in horses.

Treatment with 3 formulations of cambendazole (paste, pellets, and suspension) was compared with thiabendazole treatment in 181 Quarter Horses (females and intact and altered males) of different ages in 2 experiments. The mean output of strongyle eggs, as measured by eggs per gram of feces (epg), was reduced by at least 95% by the 3 formulations of cambendazole compared with pretreatment epg and epg in simultaneously nonmedicated horses. Eggs of Parascaris equorum were seen in 19 of the younger horses in experiment I. Parascaris eggs were not seen in postmedication fecal samples from 14 horses treated wtih cambendazole. Of the 5 horses treated with thiabendazole, 2 had postmedication Parascaris egg counts.

Animals↗
PubMed1969

Effects of phenoxybenzamine in shock due to myocardial infarction.

Treatment of cardiogenic shock with vasodilator drugs has been advocated on the basis of experimental work showing that a fall in peripheral resistance allows the cardiac output to increase without any increase in cardiac work.Seven patients suffering from shock secondary to myocardial infarction were treated with phenoxybenzamine. In two cases there was dramatic improvement in the signs and symptoms of shock, but in six of the seven cases there were severe adverse effects on respiration, including the development of wheezing and rales and rhonchi.

Aged↗
PubMed1968

Punished and unpunished responding in multiple variable-interval schedules.

The performance of rats trained on multiple variable-interval schedules was examined before, during, and after punishment. The same linear function related relative response rates to relative density of reinforcement both in the presence and absence of punishment. Equal relative suppression was seen in both the high and low reinforcement density components. The intercept value of the function was zero. Each component of the schedule was programmed on a separate lever: thus during any component, there was an opportunity for responses on the nonoperative lever (errors). The proportions of these errors declined to a near-zero value during punishment and did not regain their prepunishment values after punishment was removed, suggesting that some discrimination learning occurred during punishment. Recovery of response rate during punishment was seen only where a greater-than-zero probability of reinforcement was associated with the response.

Animals↗
PubMedDate not supplied

Observations on the effect of immersion in Bath spa water.

Immersion in water in spas has been practised for centuries and has many proponents. Despite fierce debate about its efficacy there has been little scientific evaluation of the effect of immersion in mineral waters. Eight normal subjects were immersed in Bath spa water for two hours and the renal, haematological, and cardiovascular responses were compared with those in the control periods before and after immersion. Significant, twofold diuresis and natriuresis, 5% haemodilution, and a 50% increase in cardiac index were observed in subjects immersed, sitting, in Bath spa water at 35 degrees C. These changes may constitute part of the scientific rationale for spa treatment in many states of disease.

Adult↗
PubMedDate not supplied

Analysis of patients dying within one year of starting renal replacement therapy.

BACKGROUND: The annual gross mortality of end-stage renal failure patients remains very high (approximately 15-20%) leading some to question the wisdom of accepting patients with limited prognosis for dialysis. We have reviewed the demographic and clinical characteristics of patients who died within a year of commencing renal replacement therapy (RRT) over a 5-year period to establish whether these patients could be identified at the start of therapy. METHODS: Case notes of patients who died within 1 year of commencing RRT between 1st April, 1991 and 31st March, 1996 were reviewed. Comorbidity at the start of dialysis was used to classify patients into high-, medium- and low-risk groups using two published scales to determine whether either graded a high proportion of deaths as high risk. Factors such as age, social circumstances, cause of death, renal diagnosis and mode of dialysis were also analysed. RESULTS: 17.5% of patients commencing RRT died in the first year. Not all of these patients could be identified as high risk by comorbidity assessment at dialysis initiation - 50% of patients who died were classified by one scale as medium risk. Age did not clearly predict outcome, as 42% of patients who died were less than 65 years old. CONCLUSION: These data suggest that it is difficult to use current risk stratifications to accurately predict outcome on RRT.

Adolescent↗