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Biomedical subjects

G Walsh

Publications and source records attributed to G Walsh.

106 records · Page 6Linked to original sources
PubMedDate not supplied

Mediastinal teratoma presenting as massive hemoptysis in an adult.

Massive hemoptysis is a rare but potentially life-threatening presentation in the emergency department (ED). We describe a case of massive hemoptysis caused by a mediastinal teratoma in an otherwise healthy young man. The teratoma had invaded into a bronchus and was resected successfully. The literature regarding massive hemoptysis due to mediastinal teratoma is reviewed. A differential diagnosis for massive hemoptysis is presented. The initial management of these patients in the ED and the diagnostic options are discussed.

Adult↗
PubMedDate not supplied

Fat emulsion catabolism in vitro and in vivo--sex related differences.

The removal rates of an intravenously administered 10% fat emulsion (Intralipid) from plasma in male and female conscious rats are described. The plasma concentration of fat emulsion particles at various time intervals following a bolus administration (0.2 g/kg) was measured by nephelometry. At the dose employed, the removal of fat emulsion from the plasma followed first order kinetics, ie, a constant fraction was removed from the plasma per unit of time, K2 (%/min). Females exhibited a significantly greater fractional removal rate (K2) than comparably aged males (21.0 +/- 1.0 vs 15.0 +/- 1.4, p less than 0.05). Postheparin lipoprotein lipase, measured using fat emulsion as substrate, also was significantly greater in female rats compared with males. Our results demonstrate that, in rats, fat emulsion (Intralipid) is catabolized more rapidly in females than in males and a greater lipoprotein lipase activity in female rats may be the causative factor.

Animals↗
PubMedDate not supplied

AIDS: fear of contagion among nurses.

The current moral panic about HIV/AIDS and the theories of deviance that go with it are not a new phenomenon. People expect nurses to know all about HIV/AIDS, but many experience the same fears and ignorance as the public. Empathy is crucial in the nurse/patient relationship and unfavourable attitudes lead to less than optimal care. There is a need to cultivate non-judgmental attitudes towards the care of people infected with HIV. This requires systematic and sensitive educational programmes. As most patients are nursed at home, it is the responsibility of the Government and educational bodies to strengthen the knowledge base of community nurses. The WHO's global programme on AIDS emphasizes the scope of education and promotes worldwide exchange of information and non-discriminatory policies.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Low-risk drinking guidelines: the scientific evidence.

In 1997 the Addiction Research Foundation of Ontario and Canadian Centre on Substance Abuse released updated guidelines for low-risk alcohol consumption. This paper presents the scientific rationale behind this statement. Important comprehensive overviews on the consequences of alcohol use were studied. Formal meta-analyses on morbidity and mortality were examined wherever possible. Individual elements from similar guidelines were investigated for their scientific foundation. Limited original analyses defined risk levels by average weekly consumption. The evidence reviewed demonstrated that placing limits on both daily intake and cumulative intake over the typical week is justifiable for the prevention of important causes of morbidity and mortality. Gender-specific limits on weekly consumption were also indicated. In these updated guidelines intended for primary prevention, days of abstinence are not necessarily recommended. Intoxication should be avoided and abstinence is sometimes advisable. Available evidence does not strongly favour one alcoholic beverage over another for cardiovascular health benefits.

Adult↗
PubMedDate not supplied

Do Ontarians drink in moderation? a baseline assessment against Canadian low risk drinking guidelines.

We used the 1997 Ontario Drug Monitor, a population-based, random-digit dialing survey of 2,776 adults, to obtain a baseline assessment of alcohol drinking by Ontarians against the 1997 low-risk drinking guidelines of the Addiction Research Foundation and the Canadian Centre on Substance Abuse. Average weekly alcohol consumption and the frequency of exceeding the daily limit, estimated using the graduated frequency scale, were determined for the population overall, and by sex and age group (18-44 and 45+ years). Most Ontarians drank alcohol in a pattern associated with a low risk of health consequences. About 10% of women and 25% of men drank in a style associated with some increase in acute or long-term risk. Younger men were most likely to drink in a risky pattern. Most drinkers of middle age or older, for whom cardiovascular disease is a significant health risk, consumed alcohol in a pattern associated with cardiovascular benefit.

Adolescent↗
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A little knowledge....

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Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

A phase I study of a multi-modal schedule with Corynebacterium parvum.

A Phase I study of an immuno-chemotherapy regime was carried out using C. parvum as an immune-modulator. 14 women were studied. All received doses of C. parvum ranging from 2.5 mg to 21 mg administered in 1 litre of dextrose saline over 4 h. No evidence of tumour enhancement was observed.

Adult↗
PubMedDate not supplied

A survey of patients' reactions to intravenous Corynebacterium parvum therapy.

A survey was made of patients' reactions to high dose (21 mg) Corynebacterium parvum therapy given intravenously over four hours. The patients completed a pro forma. Rigors were the commonest side effect complained of being present in nearly all patients (24/25) and being very severe in one-third (10/25). Other problems were nausea (15/25), vomiting (17/25), bone pain (12/25) and headaches (12/25). One-third also usffered with other less common side effects. Overall, patients felt the side effects were as disagreeable as those experienced with outpatient chemotherapy.

Attitude to Health↗