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Biomedical subjects

G Walker

Publications and source records attributed to G Walker.

At least 181 records · Page 10Linked to original sources
PubMed1975

Islet-cell antibodies in juvenile diabetes mellitus of recent onset.

Antibodies reacting with human pancreatic islet cells were found by immunofluorescence in the sera of 51 of 105 children with diabetes mellitus of recent onset. These antibodies were of IgG class, and several of them fixed complement and reacted with pancreatic islets of other species. Thyroid microsomal and/or gastric-parietal-cell antibodies were found in only 10 of the patients with islet-cell antibodies, and none of them had adrenal antibodies. These findings contrast with previous reports which have stressed the rarity of islet-cell antibodies in adult diabetics and their occurrence only in patients with other evidence of autoimmune disease.

Adolescent↗
PubMed1975

Viral antibody studies in pancreatic disease.

Viral studies were performed on sera from 54 patients with recent acute pancreatitis, 10 with recurrent acute pancreatitis, seven with chronic pancreatitis, and 10 with pancreatic carcinoma, and on sera from 81 age- and sex-matched controls. In 29 of the acute pancreatitis patients from whom paired sera were obtained no convincing evidence of recent viral infection was found. A higher incidence of raised antibody titres against Coxsackie B3 and B4 was observed in the group of acute pancreatitis patients compared with their controls. The possible signficance of these observations and their relationship to the aetiology of the pancreatitis and to other immunological findings are discussed.

Acute Disease↗
PubMed1975

Posterior psoas transfer and hip instability in lumbar myelomeningocele.

Seventy-two posterior psoas transfer operations performed in forty-four children with lumbar myelomeningocele were reviewed one to eight years after operation in an attempt to assess its value. Muscle charting, an objective recording of the child's walking ability, and radiographic examination of the hips were done. Hip stability was improved: 49 per cent were stable at the time of psoas transfer and 94 per cent at review. Functional results depend mainly on the level of neurological activity present: 57 per cent of the children had an acceptable functional result. Usually, posterior psoas transfer should be done as soon after the age of nine months as the child's condition will allow. Over the age of two years it should be restricted to children with activity in the third and fourth segments of the lumbar cord.

Child↗
PubMed1975

Serum antibodies in human pancreatic disease.

An immunofluorescent study of sera from patients with various pancreatic diseases and from controls was carried out using human pancreas as substrate. A reproducible pattern of immunofluorscence, consisting of a coarse granular appearance in the cytoplasm of acinar cells of the pancreas and independent of the ABO blood group system was found. This occurred in 21 of 61 patients with acute pancreatitis; it was not found in other pancreatic diseases, and occurred in only four of 170 control subjects consisting of mixed hospital patients and healthy adults. Preliminary absorption experiments suggest that the antigen is located in the microsomal fraction of pancreatic homogenates and may be organ-specific. The relationship of positive antibody tests to aetiological factors is discussed.

ABO Blood-Group System↗
PubMed1974

Hepatic disorders associated with liver-kidney microsomal antibodies.

A study of the clinical associations of a recently defined tissue autoantibody, the liver/kidney microsomal (L.K.M.) antibody, showed that out of 33 patients 26 had clinical liver disease. Fifteen of the patients had active chronic hepatitis and there were seven cases of acute hepatitis, precipitated by presumed virus A infection in three instances and by drug hypersensitivity in the other four. The remaining cases with liver disease included two with subclinical hepatitis and two with hepatocellular carcinoma. Evidence is presented that the patients with active chronic hepatitis may represent a distinct subgroup of the disease with a young mean age, an even male to female ratio, and a striking lack of other nonorgan-specific autoantibodies-that is, antinuclear and smooth muscle-which are usually present in the other autoimmune variant of the disease.

Adolescent↗
PubMed1974

Effects of sulphasalazine (Salazopyrin) on faecal flora in patients with inflammatory bowel disease.

The faecal flora of 21 patients with proctocolitis and five patients with Crohn's disease of the large bowel was examined both while sulphasalazine was being administered and during control periods. Patients with proctocolitis and Crohn's disease who were not receiving sulphasalazine had a similar flora which did not differ in any way from the normal. The effect of sulphasalazine was to decrease the numbers of opalescent-negative clostridia, enterobacteria, and total non-sporing anaerobes. It is suggested that this antibacterial effect of sulphasalazine, which has not been previously demonstrated, may be related to the beneficial effects of this drug in proctocolitis and should be investigated further.

Adrenal Cortex Hormones↗