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Biomedical subjects

G WEBER

Publications and source records attributed to G WEBER.

At least 37 records · Page 2Linked to original sources
PubMed1963

ACTINOMYCIN: INHIBITION OF CORTISONE-INDUCED SYNTHESIS OF HEPATIC GLUCONEOGENIC ENZYMES.

The cortisone-induced de novo synthesis of liver glucose-6-phosphatase, fructose-1, 6-diphosphatase, aldolase, and lactic dehydrogenase was prevented by injections of Actinomycin D in the rat. In the in vitro assay systems, addition of actinomycin exerted no effect on the enzyme activities examined. The evidence favors the concept that the increased gluconeogenesis induced by corticoids entails at a certain stage an increased rate in the synthesis of gluconeogenic enzymes.

Cortisone↗
PubMed1963

Glycogen deposition in the liver induced by cortisone: dependence on enzyme synthesis.

The deposition of liver glycogen in starved rats given a single dose of cortisone is inhibited by puromycin and actinomycin. The former agent interferes with induced enzyme formation in general, and the latter with the cortisone-induced rise in liver enzyme levels. The results suggest that the regulatory eJffect of cortisone on carbohydrate metabolism may be brought about -by its action on the cellular concentration of certain enzyme proteins.

Animals↗