Biomedical subjects
Publications and source records attributed to G W Stamp.
A case of an unusual hypertrophic gastropathy confined to the gastric antrum which presented with chronic anaemia is described. The clinical and pathological features are contrasted with Menetrier's disease and hypersecretory hypertrophic gastropathy, and a possible relation to solitary hyperplastic (regenerative) polyps is discussed.
Mammography was performed as a screening procedure on 5000 self-selected women aged between 35 and 60 years. The biopsy rate, on areas regarded as suspicious of malignancy, was 2.58% with cancer being found on histology in 18.6% of biopsied cases. Aggregated microcalcification alone was the commonest indication for biopsy but was never associated with carcinoma when all the visible foci of calcification were rounded in form. However, benign disease sometimes occurred with irregular foci of calcification. Rounded mass lesions, mostly, but not entirely, well defined, provided the second commonest indication for biopsy but were benign in the vast majority of cases. Generally ill-defined masses were often malignant when associated with microcalcification and/or spiculation. Localised ductal dilatations, with or without microcalcification, were always benign in this series. Architectural distortion was uncommon but was associated with carcinoma in each of the two cases. Spiculation was a reliable, but not invariable, indicator of malignancy. The significance of these radiological and pathological correlations is discussed with regard to case management.
Twenty-four cases with a malignant change involving one of the elements of an ovarian dermoid cyst are reported. The patients were older than those with benign ovarian dermoid cysts. Squamous carcinoma was most frequent with adenocarcinoma, undifferentiated carcinoma and a fibrosarcoma also occurring. Survival time after diagnosis was less than 1 year in 75% of the cases.
Acute postprandial gastric dilatation and associated clostridial enteritis necroticans is a well recognised but unusual clinical condition. Non-pathological overeating, gastric distension, and clostridial enteritis, termed pig-bel, has been reported in Papua, New Guinea. A similar condition (Darmbrand) was reported from Germany after the second world war, but it is not a condition seen in our society today. Gastric dilatation alone may be seen in individuals with anorexia nervosa, who may occasionally indulge in episodes of overeating (bulimia). We wish to report a case of gastric dilatation associated with a fulminating enteritis, and discuss the similarities with enteritis necroticans (pig-bel).
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Fine needle aspiration biopsy was performed on a recurrent juvenile granulosa cell tumor of the ovary in a 24-year-old woman. The cytologic appearances and the results of histochemical, immunocytochemical and ultrastructural studies are described, and the differential diagnosis with other ovarian tumors is discussed.