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Biomedical subjects

G W Reed

Publications and source records attributed to G W Reed.

65 records · Page 4Linked to original sources

Depth of myometrial invasion in endometrial cancer: preoperative assessment by transvaginal ultrasonography.

Twenty-five patients with cancer of the uterus underwent transvaginal sonography (TVS) to assess depth of myometrial invasion. All scans were performed with a 5.0-MHz curvilinear array probe (Toshiba, Inc., Tustin, CA) within 1 week of hysterectomy. In 21 cases (84%) sonography correctly predicted the depth of invasion (within 15% of actual). Only one of three cases with cervical involvement was detected. Transvaginal sonography can accurately detect depth of myometrial invasion and is well suited as a screening test to detect high-risk patients for consultation or referral.

Female↗

Bone and soft tissue changes in paraplegic patients.

The loss of bone mineral in 66 paraplegic patients has been measured in the lower femoral shaft by scanning the leg with a beam of mono-energetic radiation from 241Am. The profile of the transmitted radiation was used to determine a parameter which was related to bone mass. The bone mass of paraplegic patients was significantly lower than normal. Persistent paralysis does not lead to a continued fall in bone mass, but once it has fallen, bone mass remains constant. Soft tissues also showed a muscle/fat ratio was lower than normal.

Adolescent↗

Changes in skeletal mineral in patients on prolonged maintenance dialysis.

The measurement of bone loss in patients undergoing maintenance dialysis over a period of two and a half years is reported. The tendency to lose bone is a likely event in renal failure, but depends more on the individual patient than on the type of dialysis used, provided that steps are taken to prevent avoidable calcium loss during dialysis. Vitamin D therapy was an important factor in preventing bone loss in some cases. The tendency to lose bone more readily when both kidneys were absent may have reflected a deficiency of 1-25 dihydrocholecalciferol. On the other hand, bone loss was also observed in transplanted patients. The need to measure bone loss at regular intervals once renal failure has been diagnosed is stressed.

Adolescent↗

Loss of skeletal calcium by patients on maintenance dialysis.

Direct radiological measurements of the mineral content of femoral bone were performed in 13 patients on maintenance dialysis. They were found to be sufficiently sensitive to be used for monitoring, and it is suggested that the technique gives more information than do calcium-balance studies.

Adolescent↗

Factors affecting access to menopause information.

OBJECTIVE: As female life expectancy increases, women spend a greater proportion of their life in menopause. Menopausal women may benefit from preventive treatments, such as hormone replacement therapy, and are more likely to use medical treatments if they have access to information about menopause. The purpose of this study was to identify women's needs with respect to learning about menopause. DESIGN: A 20-question survey was administered anonymously to 116 women during outreach programs. Data were separated and evaluated by race and level of education. RESULTS: A significant association was found between access to information about menopause and both race and education level. Being African American or having less than a college education was associated with a twofold risk (p < 0.01) for not having a source of menopause information. A significant relationship was found between a woman's rating of her current knowledge of menopause and access to source of information (p = 0.03); women who did not have an information source felt the least knowledgeable about the subject. Women varied in the ways in which they are comfortable with learning about menopause. Different groups of women seemed to prefer different methods of learning about menopause. CONCLUSIONS: Both level of education and race are associated with a woman's ability to obtain information about menopause. To enhance women's understanding of health during menopause, information must be readily available. This information should be presented to women through educational programs that are designed to meet the needs of varied groups of adult women.

Adult↗

Further clues to recognition of patients with fibromyalgia from a simple 2-page patient multidimensional health assessment questionnaire (MDHAQ).

OBJECTIVE: To analyze quantitative scores for pain, fatigue, functional disability, and the number of symptoms on a review of systems on a multidimensional health assessment questionnaire (MDHAQ), including the ratios of scores for pain to physical function and fatigue to physical function, and to further study how these scores can help to identify patients with fibromyalgia. METHODS: All consecutive patients seen at a rheumatology clinic completed a 2-sided, 1-page MDHAQ at each visit to assess physical function, pain, fatigue, global status, helplessness and review of systems, and had their erythrocyte sedimentation rate (ESR) measured. Scores for these variables were analyzed in 78 consecutive patients with fibromyalgia over a two-year period, and in 149 patients with rheumatoid arthritis (RA) as a "control" group. A subset analysis was conducted in patients with RA who were classified independently according to clinical criteria as having or not having coexistent fibromyalgia. Descriptive statistics, logistic regression, and receiver-operating-characteristic curves were computed for patients with fibromyalgia and compared to patients with RA. RESULTS: Patients with fibromyalgia had high ratios of pain:physical function and fatigue:physical function scores, and a high number of reported symptoms. These quantitative data differed significantly from patients with RA. Patients with fibromyalgia also had a lower ESR than patients with RA, whose scores were similar whether or not there was coexistent fibromyalgia. Patients with fibromyalgia were distinguished equally well from patients with RA by patient questionnaire data as by the ESR. CONCLUSION: A simple 1-page, 2-sided patient questionnaire provides quantitative information which may contribute to identify patients with fibromyalgia, including patients with RA who may also have coexistent fibromyalgia.

Blood Sedimentation↗

The umbilical artery Doppler ultrasonographic gradient: confirmation, cause, and comparison of continuous-wave and duplex ultrasonographic pulsed-wave measurements.

The umbilical artery Doppler ultrasonographic gradient has been described, and the need for site-specific nomograms has been pointed out. However, controversy still exists about the cause of this phenomenon and the optimal site for obtaining umbilical artery Doppler ultrasonographic measurements. Cross-sectional measurements of umbilical artery flow velocity waveform (FVW) systolic/diastolic (S/D) ratios were therefore made in 35 gravid women during the second or third trimester of pregnancy with both duplex pulsed-wave (PW) and free-standing continuous-wave (CW) Doppler ultrasonographic equipment. Multiple duplex PW Doppler ultrasonographic signals were recorded at the abdominal cord insertion, placental cord insertion, and free cord sites. Multiple CW Doppler FVWs were obtained from four quadrants, in decreasing order of ease of measurement. Repeated-measures analysis of variance demonstrated a statistically significant decrease in mean and median values of the umbilical artery S/D ratio from the abdominal cord insertion site to the placental cord insertion site. The reduction in the value of the S/D ratio as the placental cord insertion site is approached results more from a decrease in the peak systolic maximum velocity envelope than from an increase in diastolic velocities. Moreover, mean and median CW Doppler ultrasonographic values correlate most closely with corresponding PW measurements of the free cord segment. These data confirm the presence of the umbilical artery Doppler ultrasonographic gradient. Decreasing values of the S/D ratio from the fetal abdomen to the placenta are a result of attenuation of the systolic maximum velocity envelope.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗