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G W Jones

Publications and source records attributed to G W Jones.

139 records · Page 8Linked to original sources
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Comparison of the addition of T and N integer scores with TNM stage groups in head and neck cancer.

The 1987 TNM classification system modified T and N definitions for squamous cell carcinomas of the head and neck. It did not change stage groupings (I through IV). The primary purpose of clinical staging is to divide patients into prognostically meaningful groups. The 1987 changes to the TNM T and N descriptions may not have removed the previously established heterogeneity within stage groups III and IV which existed before 1987. The development of a stage grouping system called TANIS (the T And N Integer Score), which is formed by adding the integer values of the T and N classifications, is reported herein. We compared the prognostic performance of T, N, TNM stage group, and TANIS stage for radiotherapy response and survival using data from 86 patients with newly diagnosed, measurable TNM II (oral cavity), and localized TNM III-IV squamous cell carcinomas of the head and neck, excluding nasopharynx, who were randomized to test 5-fluorouracil-methotrexate sequencing. The sequencing of chemotherapy was shown to make no difference to prognosis. All patients received 60 Gy of radiotherapy in 6 weeks. As compared to T, N, and the TNM stage group system, TANIS was the single best predictor for a complete response to radiotherapy (p = 0.0005). TANIS was also the single best predictor for survival from randomization (p = 5 x 10(-6)). With the 86 patients divided into three groups (TANIS 2 to 3, 4, and 5 to 7), TANIS provided a better prognostic discrimination than did the TNM stage grouping method (TNM II, III, and IV).(ABSTRACT TRUNCATED AT 250 WORDS)

Carcinoma, Squamous Cell↗
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Procainamide-induced hemolytic anemia.

The paper reports a case of hemolytic anemia induced by procainamide hydrochloride treatment. Decreases in hemoglobin concentration are correlated with 11 months of procainamide treatment along with a marked increase in hemoglobin following cessation of the drug. The patient exhibited no symptoms suggestive of drug-induced Lupus Erythematosus that has been frequently reported as a sequela of procainamide therapy. Direct antiglobulin tests were consistently positive throughout the clinical course, and an ether-eluate prepared from the patient's red blood cells showed panagglutinability. The antibody in the eluate reacted with Rhnull, D--, LW negative, and U negative red blood cells without addition of procainamide or pretreatment of red blood cells with the drug. It is noted that this antibody reacts similarly to the antibody produced as a consequence of alpha-methyl-dopa therapy.

ABO Blood-Group System↗
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Models for studying the role of bacterial attachment in virulence and pathogenesis.

Simple in vitro tests for bacterial adhesion can indeed identify the various adhesive mechanisms of bacteria on an immunologic, physiochemical, biochemical, and genetic basis. Difficulties in interpretation arise, however, when attempts are made to relate the presence of a given adhesion to the colonizing ability or virulence of a bacterium. The reasons for this confusion are threefold: (1) there is more than one basic mechanism by which bacteria may associate with mucosae; (2) numerous intervening reactions in the mucosal microenvironment modify the various steps leading to association; and (3) mucosal association may sometimes be detrimental to a bacterium. Bacterial association with the mucosa, therefore, is determined by the final equilibrium established as a consequence of various synergistic and antagonistic reactions. An understanding of such a complex, interdependent system of reactions cannot be gained solely by studying each of its component parts in isolation. More complex models, such as those developed in experimental animals, are therefore required, and the relationship between adhesion and colonization must be explored within the conceptual framework employed by ecologists.

Adhesiveness↗
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HIV-related articles.

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Acquired Immunodeficiency Syndrome↗
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Renal cell carcinoma.

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Adenocarcinoma↗
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Characterization of prostatic carcinoma among blacks: a preliminary report.

This study was designed to compare United States (Washington, DC) black prostatic carcinoma patients (high-risk group) with Nigerian (Ibadan) black prostatic carcinoma patients (low-risk group). Although the material is meager, preliminary analyses suggest that carcinoma of the prostate is a common disease in both US black men (196 of 1000 autopsies) and in Nigerian black men (67 of 1000 autopsies). The tumor tends to be of a higher histologic grade (less well differentiated) and the carcinomatous foci are more numerous in the Nigerian patients. Fifty-three percent of US patients are in stages I and II when the disease is first discovered. Plasma testosterone, estrone, and estradiol concentrations did not differ significantly between US patients and controls. A statistically significant positive association is indicated between carcinoma of the prostate and the following epidemiologic variables: racial admixture, age of puberty, and age of first coitus. The median age of necropsy cases with carcinoma was 50.0 years in Nigeria and 68.3 years in the US.

Aged↗
PubMedDate not supplied

Characterization of prostatic carcinoma among blacks: a continuation report.

A clinical and pathologic comparison of carcinoma of the prostate in a high-risk US (Washington, DC) black population and in a low-risk Nigerian (Ibadan) black population is presented. Fifty-two percent of American patients were in clinical stages I and II, whereas only 10% of Nigerian patients were in the same stages. Testosterone and estradiol blood levels were significantly lower (P less than 0.05) in patients with carcinoma of the prostate from Ibadan compared with American black prostate cancer patients from Washington, DC. Age-standardized incidence rates (world standard) for 1000 autopsies for micro (incidental)-carcinoma were approximately equal in American and African black men. The incidence rate of invasive carcinoma was, however, even after adjustment for age, higher in American black men than in African men.

Black or African American↗