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Biomedical subjects

G Volden

Publications and source records attributed to G Volden.

At least 55 records · Page 3Linked to original sources
PubMed1985

Combined UVB and UVA phototherapy of atopic eczema.

The effect of combined UVB-UVA treatment in a group of 23 patients with severe atopic eczema was compared to UVB therapy alone in 33 patients. Mean age and number of treatments were approximately the same in the two groups. With UVB-UVA treatment, 48% achieved complete remission and in another 48% good improvements were obtained as compared to 27 and 58%, respectively, in the group treated with UVB alone. A few failures were recorded in the UVB group. Some possible explanations for the better effect of the combined UVB-UVA treatment are given.

Adolescent↗
PubMed1985

Treatment of mouse carcinomas with intratumoral injections of hematoporphyrin derivative and red light.

Hairless mice with subcutaneously transplanted Lewis Lung carcinomas were used to study the effects of treatments with hematoporphyrin derivative (HPD) administered by intratumoral injection, followed by exposure to red light. A tumor cure rate of 70-90% was obtained following a single treatment. The therapeutic response increased with increasing HPD doses and light fluences. At a certain dose a plateau seemed to be reached, where further dose increase only gave a limited gain in treatment response. A narrow range seems to exist between beginning therapeutic response and frank necrotic destruction. The number of mice that died after treatment increased with increase in tumor size, and there was a correspondence between the time of death and the severity of the phototoxic reactions. The best therapeutic response was obtained when the irradiation was performed 1/2-1 h after injection, and with tumors less than 6-8 mm in diameter.

Animals↗
PubMed1984

[Treatment of acne vulgaris. Double-blind study of a combination of 5% benzoyl peroxide/2% miconazole (Acnidazil) and tretinoin 0.05%].

The clinical efficacy and tolerance of a combination of benzoyl peroxide 5% and miconazole 2%, Acnidazil, for the treatment of facial acne vulgaris have been compared with those of tretinoin 0.05% in a double-blind study with 40 patients during 12 weeks. The combination of benzoyl peroxide and miconazole gave improvement in 82% of 22 patients, compared to tretinoin which gave improvement in 50% of 18 comparable patients. The difference is significant. Also, side-effects were significantly less in the benzoyl-miconazole group than in the tretinoin group.

Acne Vulgaris↗
PubMed1984

Light penetration of normal and photokeratitis induced rabbit cornea.

The passage of light through photokeratitic and normal corneas was investigated using a grating monochromator. The energy output was measured at each selected central wavelength from 280 to 700 nm. The absorption by epithelial and stromal suspensions was continuously registered over the total light spectrum in a recording spectrophotometer. The penetrating quantity of the physiologically effective middle wave ultraviolet (UVB) rays varies according to wavelengths from about 11% at 290 nm up to 50% at 320 nm. Photokeratitis did not alter the transmission characteristics at wavelengths below 310 nm. At longer wavelengths transmission was significantly decreased in photokeratitic corneas compared to normal. No difference was found between the light absorption of the supernatants of photokeratitic and normal corneas.

Animals↗
PubMed1984

Lysosomal hydrolases in neutrophils, mononuclear cells and serum during Escherichia coli endotoxinaemia in pigs.

The appearance of 10 different lysosomal enzymes in leucocytes and serum were studied during various stages of Escherichia coli endotoxinaemia in pigs. The animals were monitored in halothane anaesthesia and ventilated with a mechanical ventilator. The endotoxin infusion induced a marked increase in pulmonary artery pressure while the systemic blood pressure was significantly lowered. A pronounced decline in circulating leucocytes occurred. There was a general trend of intracellular reduction of lysosomal enzymes in both PMN and mononuclear cells, whereas increasing serum levels of the same enzymes occurred. Significantly higher serum levels of all lysosomal enzymes were found 5 h after start of endotoxin infusion compared to preinfusion values, while a significant acidosis in the aorta blood was registered. These results indicate that lysosomal enzymes are released from white blood cells following endotoxin stimulation. When local pH values allow enzyme activity, they may contribute to the tissue destruction seen in endotoxinaemia.

Animals↗
PubMed1984

13-cis-retinoic acid effective in mycosis fungoides. A report from the Scandinavian Mycosis Fungoides Group.

Twenty patients with mycosis fungoides and four with Sézary's syndrome were treated with 13-cis-retinoic acid as single therapy in an initial dose of 1 to 2 mg per kg body weight in most cases. Complete remission in mycosis fungoides was obtained in six cases (33%) and partial remission in another ten cases (50%). No convincing response was observed in three cases, and progression of limited nodular lesions occurred in one case. In cases responding to treatment the first sign of remission was observed within two to four weeks. Our short-term experience is that the drug is effective in early as well as advanced stages of mycosis fungoides. Patients with Sézary's syndrome, however, did not respond to the same extent.

Adult↗
PubMed1984

Trichophyton-rubrum-infected toenails treated with ketoconazole and partial nail avulsion.

30 patients with totally 178 toenails infected with Trichophyton rubrum were randomly treated with ketoconazole alone for 4 months (group A) or in combination with chemical nail avulsion (group B). Of the 14 patients in group A who completed the treatment, 4 (28%) were cured 6 months later, compared to 8 (53%) of 15 patients in group B. In 4 cases, transient elevated hepatofunction enzymes occurred. Gastrointestinal disturbances caused withdrawal in 1 case.

Adolescent↗
PubMed1984

Psoriasis provoked by beta-blocking agents.

23 patients suffering from psoriasis and being treated with beta-blocking agents were compared to a control group regarding psoriasis activity. Seven out of the 23 were affected by psoriasis after introduction of the beta-blocking drug. The mean age of onset was significantly higher (p less than 0.001) than that of the control group, which supports the provoking effects of beta-blocking agents. Remission occurred in 3 out of 4 patients after medication was stopped.

Adrenergic beta-Antagonists↗
PubMed1984

Phytophotodermatitis.

Several plant families contain species liable to cause phytophotodermatitis. They include the Umbelliferae of which Ammi majus has been known for centuries and the Rutacea to which Citrus bergamia belongs. Phototoxic plants are also found in, e.g., the Moraceae, Leguminosae, Rosaceae and Compositae plant families. The photoreactivity of the plants depends on their furocoumarins (psoralens) content. These cause skin damage by phototoxic mechanisms, when activated by longwave ultraviolet radiation (UVA). The results are clinical changes such as erythema, bullae in the skin 24-72 h later, followed by hyperpigmentation. For the strongest phototoxic plants the content of the major phototoxic furocoumarins like bergapten or xanthotoxin have been calculated at approximately 0.5 g/100 g dried plant weight, but it varies between plant parts and also with the age of the plant. Repeated contact may occasionally lead to photocontact allergy.

Furocoumarins↗
PubMed1984

High pressure liquid chromatographic separation of furocoumarins in Heracleum laciniatum.

Furocoumarins from chloroform extraction of Heracleum laciniatum were separated by high pressure liquid chromatography (HPLC) with microparticulate silica gel column investigating different concentrations of acetonitrile and water, acetonitrile and methanol and acetonitrile, methanol and water for mobile phase. With a mixture of 42:43:15 of the latter for mobile phase optimal separation was obtained of the 6 furocoumarins from the plant. Removal of lipid fractions of plant extractions with hexane is recommended to avoid damage to the HPLC column.

Chromatography, High Pressure Liquid↗