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Biomedical subjects

G Viganotti

Publications and source records attributed to G Viganotti.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Teleradiography and tomography in the search for pulmonary metastases in 132 cases of soft tissue and bone neoplasms].

In recent years whole lung tomography (WLT) has been considered mandatory in the staging of some neoplastic diseases, particularly of soft tissues and bone tumors. Since WLT is an exacting roentgen examination, its usefulness was evaluated by analysing 132 consecutive patients submitted to orthogonal chest roentgenograms and WLT, from January 1979 to October 1981 at the National Cancer Institute of Milan. A comparison between WLT and traditional chest X-ray examination was performed in order to evaluate how much tomography is significantly useful in improving diagnosis of lung metastases. From this analysis, the authors conclude that WLT is generally unnecessary when chest roentgenograms are negative, whereas it is useful when single or multiple lung metastases are already evident by traditional X-ray examination. In these cases WLT allows a more accurate identification of the metastases from the point of view of their number and site, which is important not only for the treatment choice but also for the check of its effectiveness.

Bone Neoplasms↗
PubMed1982

[Radiological and telethermographic diagnosis of breast lymphomas (28 cases)].

Twenty eight patients with histologically proven primary or secondary malignant lymphoma of the breast were evaluated by mammography and telethermography between 1968 and 1980 at Istituto Nazionale Tumori of Milan. This histological type is rather unusual and poor is the radiological literature on the matter. The roentgenographic findings showed especially isolate nodes with clear-cut or irregular outline, multiple displasic lesions or diffuse inflammatory-like disease. Because of such a variety of radiological matters, diagnosis is often uncertain. No significant difference between primary or metastatic disease was seen in radiological patterns of non-Hodgkin lymphomas. In the three cases of Hodgkin's lymphoma radiological findings suggested inflammatory disease. Telethermography was usefully associated showing, in the majority of cases, high hyperthermia also in "benign" mammographic patterns.

Adult↗
PubMed1982

[Radiography signs of non-Hodgkin lymphomas with pulmonary localization].

The authors have examined a series of 992 patients with non-Hodgkin lymphomas treated at the National Cancer Institute of Milan from 1966 to 1977. The pulmonary parenchymal lesions were studied. The lung involvement by lymphomas is unusual and show a difficult X-ray diagnosis. A classification deriving from the experience of the various roentgenologic findings is proposed. Furthermore the most important differential diagnostic difficulties, some of which have an impossible solution even with the most recent X-ray techniques, are analized.

Humans↗
PubMed1982

[Thermography in the follow-up of bone and soft tissue tumors].

Thermography was used for the follow-up of 16 cases of bone tumors and of 16 cases of soft tissue tumors, after conservative treatments (surgery and/or radio- and chemio-therapy). The hyperthermia, which corresponds to the primary tumor, underwent a marked reduction during the first six months after the treatment. The thermographic picture appeared normal at the first follow-up of 12/16 bone tumors and of 9/16 soft tissue tumors. The presence of local recurrencies, at 12 months distance or more, corresponded to a new hyperthermic spot and to the increase of local vascularity. Thermography is proposed as a simple and harmless procedure for the follow-up of bone and soft tissue tumors after conservative treatments.

Adolescent↗
PubMed1981

Multimodal treatment for locally advanced breast cancer. Result of chemotherapy-radiotherapy versus chemotherapy-surgery.

In a prospective randomized study, the efficacy of two combined modality approaches (chemotherapy plus radiotherapy or chemotherapy plus mastectomy) was tested in a total of 132 women with locally advanced breast cancer. Chemotherapy consisted of Adriamycin plus vincristine (AV) administered for three cycles before either local-regional modality and subsequently for seven additional cycles. Although a higher proportion of women achieved complete remission after mastectomy (100%) compared to women given radiotherapy (60%), the total response rate at the end of combined modality was identical (75%). There was no significant difference between the two treatment groups in terms of patterns of treatment failure, median duration of response, and total survival. Treatment was not influenced by menopausal or estrogen receptor status. Two patients of the surgical group showed Adriamycin-induced cardiomyopathy after cumulative doses less than 500 mg/m2. The results of present study failed to indicate that surgery per se improved the overall results including local control, over radiotherapy in a combined modality setting.

Adult↗
PubMed1981

[The value of mammography in 1203 breast cancers (author's transl)].

The value of clinical mammography is reviewed on 1203 consecutive cases of histologically proven breast malignancies examined from 1971 to 1978 at the Istituto Nazionale Tumori, Milan, and at the Radiological Department, University of Milan. The diagnostic effectiveness of mammography in this case-list corresponds to approximately 80%: the influences of the histotype and of the tumor's size on these results are reviewed and discussed. The main radiographic signs of malignancy are presented and their importance in reaching a correct diagnosis is outlined. The advantages and drawbacks of mammography are discussed and, amongst these latter, emphasis is given to structurally dense breasts as an intrinsic factor limiting the effectiveness of mammography.

Adolescent↗
PubMed1981

[Radiological diagnosis in 229 cases of breast fibroadenoma].

From 1976 to 1977, 705 patients with a fibroadenoma of the breast, histologically proven by biopsy, were observed at the Istituto Nazionale Tumori of Milan. In 229 cases, the clinical examination was followed by mammography or xeromammography; in 65/229 patients telethermography was also carried out. The aspects of fibroadenoma at x-ray examinations are described together with the difficulties to reach an exact diagnosis: the cases in which a false positive diagnosis of cancer was done are emphasized.

Adenofibroma↗
PubMed1980

Thermal gradient and response to estrogens or antiestrogens in advanced breast cancer.

The correlations between the thermal gradient of superficial breast cancer lesions (before and 15 days after starting treatment) and the end results of hormonal therapies with estrogen and antiestrogens were investigated. Forty-four women with a median age of over 70 with locally advanced breast cancer and/or metastases mainly located in soft tissues entered the study. Twenty-two patients were treated with diethylstilbestrol sodium diphosphate (20 mg/day i.m.) and the other 22 with tamoxifen (20 mg/day orally). The initial iperthermia was reduced after 15 days in more than 50% of the cases and remained stationary in the others. The cases with a thermal gradient more than 2 degrees C of the tumors did better, in terms of remission, following therapy (64.7% versus 37.0%. However, an early decrease of the same gradient in the course of therapy appears scantily related to the response. The therapeutic results in the 2 groups were very similar: 45.5% complete or partial regression, with a median duration of more than 8 months, in those treated with diethylstilbestrol and 50%, with a median duration of more than 11 month, in those treated with tamoxifen. Only in some cases of the first group of patients the treatment was discontinued due to severe side effects.

Adult↗
PubMed1980

Report on 42 cases of postirradiation lesions of the brachial plexus and their treatment.

Here we report 42 cases of postirradiation lesions of the brachial nerve plexus in patients treated with radiotherapy after radical mastectomy. These lesions usually appeared at least 1 year after treatment, and motorial disturbances always developed, even if initially they may have been absent. A comparison of the case material indicates that a reduction in the dose administered to the supraclavicular region and exclusion of the axillary region from the treatment resulted in a significant reduction in the incidence of these lesions. In fact, in a group of 490 patients treated by the old radiotherapy method at the Istituto Nazionale Tumori of Milan (i.e., administration of 6000 rad to the brachial nerve plexus), 16 cases of lesions at this plexus were observed. In a group of 200 patients treated instead with a new method (i.e., administration of 4900 rad to the brachial nerve plexus and exclusion of the axillary region), no nerve lesions were observed, with significance levels, according to Fisher's test, less than 0.9%. Since radiolesions at the brachial nerve plexus have a very bad prognosis with regard to functioning of the limb and physiotherapy is of little help, this new therapeutic method is very useful, and it is not accompanied by an increase in the number of local recurrences as compared to the old method.

Brachial Plexus↗
PubMed1980

[X-ray diagnosis of neoplastic breast calcifications after radio- and chemo-therapy (author's transl)].

The morphological aspects of calcifications in inoperable breast cancers were investigated through repeated mammographic examinations before and after radiotherapy and/or chemotherapy. Aim of the study was to find out the modifications induced by therapy. Different radiological patterns observed during treatment and follow up are described in details. Some findings concerning calcifications, such as modifications of number, distribution, size and shape or new evidence of micro- and macro-deposits are analyzed and discussed. A correlation between radiological findings and clinical response to radio- and chemo-therapy is attempted, but wider experience and information are needed.

Breast Neoplasms↗