Tracheal lacerations after intubation.
Explore the source record for details and available documents.
Humans↗
Biomedical subjects
G Vidal
Publications and source records attributed to G Vidal.
NMR studies of inorganic phosphate compartmentation in the isolated rat liver during acidic perfusion.
Mitochondrial inorganic phosphate has been shown to be undetectable by 31P NMR in the isolated rat liver perfused under physiological conditions. Cold perfusion (4 degrees C) with valinomycin (K+ ionophore) induced the appearance of an additional resonance assigned to P(i) from mitochondrial compartment (P(i,mito)) (Thiaudière et al., 1993, FEBS Lett. 330, 232-235). Here we have demonstrated that P(i,mito) can be detected by NMR under normothermic conditions (37 degrees C) in acidic (pH 6.5, bicarbonate-free) perfused liver using 50 nM valinomycin or 10 microM N,N'-dicyclohexylcarbodiimide (DCCD, a mitochondrial H+-ATP synthase inhibitor). These conditions resulted in a significant increase in mitochondrial P(i) content. In the presence of valimomycin, pH values of 7.00+/-0.07 and 6.60+/-0.10 (n = 7) for mitochondria and cytosol, respectively, were determined from the chemical shift values of P(i) resonances. Electron microscopy demonstrated a large matrix swelling under valinomycin perfusion, explaining the increased level of mitochondrial P(i). The amount of mitochondrial P(i) measured by NMR increased linearly with the cellular ATP depletion, suggesting a mitochondrial influx of P(i) from the cytosolic compartment with valinomycin perfusion. Moreover, the level of matrix P(i) was dependent on the cytosolic pH value, the resonance being not detectable at physiological cytosolic pH. During mitochondrial swelling, P(i) influx was likely to be associated with proton influx, owing to the stability of transmembrane pH gradient and matrix proton concentration.
Adenosine Triphosphate↗
[Conservative treatment of 2 tracheal lesions secondary to anesthetic intubation].
This case report describes two patients admitted to our hospital for elective surgery, one for biliary disease and the other for vascular disease. Shortly after surgery each presented a clinical picture attributable to membranous tracheal pars rupture caused by anesthetic intubation. Airway lesions were diagnosed and, after patient status was evaluated, conservative medical treatment was prescribed in both cases. Outcome was excellent, with no complications, within a few days. These cases demonstrate the efficacy of this way of managing this potentially serious complication.
Aged↗
Giant cell (temporal) arteritis and secondary renal amyloidosis: report of 2 cases.
Renal involvement is unusual in giant cell (temporal) arteritis (GCA). Microscopic hematuria and minimal proteinuria responsive to steroid therapy have been described as the most frequent renal alterations. The nephrotic syndrome in GCA has been rarely reported. We describe 2 cases of GCA with nephrotic syndrome, one at the time of diagnosis, the other 2 years after treatment. Percutaneous renal biopsy in both cases disclosed secondary renal amyloidosis confirmed by permanganate sensitivity and immunohistochemical analysis. To our knowledge, cases of GCA and secondary amyloidosis have not been reported.
Aged↗
Conservative treatment of tracheal lacerations secondary to endotracheal intubation.
Explore the source record for details and available documents.
Female↗
Temperature dependence of NMR relaxation times of nucleoside triphosphates and inorganic phosphate in the isolated perfused rat liver. Effect on Pi compartmentation.
The effect of temperature on 31P NMR spectra from isolated perfused rat livers was studied at 9.4 T. Relaxation times (T1 and T2) of uncleoside triphosphates (NTP) and inorganic phosphate (Pi) were determined at 37, 25, 15, and 4 degrees C. Under hypothermic conditions, an unexpected apparent line sharpening in the Pi spectral region and a clear emergence of an additional Pi resonance were observed. This additional signal was assigned to mitochondrial Pi. T1 values obtained for cytosolic and mitochondrial Pi at 4 degrees C were 1.14 +/- 0.24 s (n = 5) and 0.71 +/- 0.18.s (n = 5), respectively. No significant mitochondrial contribution to the Pi resonance was observed at 37 degrees C. Quantification of Pi and NTP liver contents at 37 and 4 degrees C was performed by comparing the perfused liver spectrum and the corresponding perchloric acid extract spectrum. Under experimental conditions of low external Pi (0.12 mM), it was concluded that intracellular Pi was completely NMR-visible at 4 and 37 degrees C. The observation of the mitochondrial Pi signal at 4 degrees C was well explained by an increase in the Pi level within the matrix, in response to the mitochondrial swelling induced by hypothermia, as observed by electron microscopy. T2 values for the cytosolic Pi at 37 and 4 degrees C were 17 +/- 4 ms (n = 8) and 22 +/- 4 ms (n = 10), respectively. Comparison with measured linewidths indicated that line broadening for the main phosphorylated metabolites--including matrix Pi--was the result of B0 field inhomogeneity. The additional broadening of the cytosolic Pi resonance at 4 and 37 degrees C was attributed to pH heterogeneity within the liver.
Animals↗
[Left lower lobectomy by video-assisted surgery].
Explore the source record for details and available documents.
Adenocarcinoma↗
[The future of psychiatry].
Explore the source record for details and available documents.
Forecasting↗
[Schizophrenia, a disease in extinction?].
Explore the source record for details and available documents.
Female↗
[Lipomyelomeningocele: experience with 16 operated cases].
Sixteen patients with lipomyelomeningoceles were operated by microsurgery technics from 1980 to 1991. Patients with lipomyelomeningoceles inappropriately treated or not submitted to treatment will develop significant neurological sequelae. In the authors' opinion, proper management of the patient with spinal lipoma requires early prophylactic resection of the lipoma and untethering of the spinal cord.
Adolescent↗
[The first case of melancholia in Rio de la Plata].
Alonso Cabrera's is the first recorded case of melancholy in the history of the River Plate area so far. It is the author's contention that melancholy, as it appears in Western countries nowadays, could not have appeared prior to the Renaissance period: Indeed, it was necessary that Europeans were in a position to achieve a sufficient point of personal differentiation so that they could feel responsible for their acts by means of guilt--hence falling into melancholy.
Argentina↗
Dopaminergic and serotonergic activity in the hypothalamus during early and late pregnancy.
Push-pull cannulae were implanted into the arcuate nucleus of pregnant or ovariectomized (OVX) rats, and the perfusate samples were analyzed for biogenic amines and their metabolites. Injection of pargyline, a monoamine oxidase inhibitor, resulted in a decrease in 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) levels in the samples, and detectable amounts of dopamine (DA) and serotonin (5-HT), which were usually not measurable prior to injection. Administration of 5-hydroxytryptophan resulted in a sharp increase in 5-HIAA and 5-HT levels in the perfusates, and no change in DOPAC levels. Push-pull perfusion was done between midnight and 06.00 h on day 8 and 16 of pregnancy. In those rats which showed a nocturnal prolactin (PRL) surge on day 8, 5-HIAA levels were very high compared to those that did not, or compared to those on day 16, which had chronic low PRL levels. DOPAC levels were not significantly different in the 3 groups. Perfusion of medial basal hypothalamic (MBH) fragments taken from mother rats on day 8 of pregnancy during the PRL surge spontaneously released more DA or 5-HT than did fragments taken on day 16 at the same time of day. These results suggest that serotonergic activity in the MBH is higher on day 8 of pregnancy, in parallel with the occurrence of PRL surges, than on day 16 when no surges are present. Dopaminergic activity, as measured by DOPAC levels in push-pull samples, does not appear to be different between the two days.
3,4-Dihydroxyphenylacetic Acid↗
[Competence and the incompetent].
Very much like egoism, competence is one of life's ingredients in its own right Living beings compete among themselves to secure their territoriality (as far as Man is concerned, his personality). Free competence favors people's economic, ethic, and cultural development. Only incompetent people feel sore at competence.
Competitive Behavior↗
[In defense of egoism].
Every being alive on earth is an offs ing of a form of centripetal force. Human behavior--from its most elementary states up to its most exquisite differentiae--is certainly determined by egoism. If we dare admit this fundamental egoism, then--some day--we may come to exercise a free and conscious influence upon our own evolution.
Defense Mechanisms↗
The oldest eukaryotic cells.
Explore the source record for details and available documents.
Biological Evolution↗