[Study of the electrophysiologic effects of propafenon in patients with cardiac pre-excitation].
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Biomedical subjects
Publications and source records attributed to G Vergara.
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The electrophysiological basis of the treatment of hyperkinetic "refractory" arrhythmias with rate - programmable pacemakers, stems from the pacing-inducted electrophysiological modifications with higher and time programmable threshold rates being obtainable to suppress the arrhythmias. Furthermore antiarrhythmic agents, that must be generally associated, are more safely employed. This is a new application in clinical arrhythmology of a particular type of permanent pacemaker whose classic indications are well known. The Authors report their experience relative to 16 selected patients affected by severe cardiopathies. Three types of pacemakers were employed: Omnis Stanicor Cordis; Microlith C.P.I.; and Byrel A-V Sequential, Medtronic. The results, in term of the suppression of the arrhythmias, were encouraging. The most striking problem is to match the "rate threshold" for the suppression of the arrhythmia with the patient's hemodynamic tolerance: not infrequently in fact the programmed rates are poorly tolerated by the patient either because of heart failure or due to coronary insufficiency. These patients need frequent adjustment of the stimulation rate. The availability of rate programmable pacemakers with steps of one beat per minute, of A-V sequential stimulation and, when feasible of atrial stimulation, undoubtedly plays an important role in clinical arrhythmology.
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The authors report two clinical cases (one with WPW syndrome) of paroxysmal supraventricular tachycardia caused, in one case, by sino-atrial node or perisinusal nodal tissue re-entrance and in the other case by re-entry in the lower atrium and the high part of the A-V node junction. Both present A-V node Wenckebach periodism, which can be distinct from reciprocating tachycardias, through an anomalous pathway or within the A-V node, which have a typical A-V conduction in the ratio of one to one. But A-V node Wenckebach periodism makes it hard to differentiate between reciprocating and ectopic atrial tachycardias, as the latter often has an A-V block. The effects of two antiarrhythmic drugs (Verapamil, Amiodarone) on echo-zone duration, on initiation and on prophylactic long-term treatment of paroxysmal tachycardias are also reported and discussed.
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The authors report the results of rapid atrial stimulation in the treatment of 12 cases of junctional tachycardia (J.T.), 20 cases of atrial tachycardia (A.T.) and 43 cases of atrial flutter (A.F.). Sinus rhythm was restored in 91.6%, 70% and 60.4% of the cases for J.T., A.T. and A.F. respectively, either when pacing was discontinued or following a period of atrial fibrillation (from a few minutes to several hours). Fifteen per cent of the cases of A.T. and 25.5% of the cases of A.F. turned into stable atrial fibrillation with reduction of ventricular rate. The authors believe that this technique is a valuable alternative to D.C. countershock when medical treatment has proved ineffective and when countershock may be hazardous.
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