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Biomedical subjects

G Verdonk

Publications and source records attributed to G Verdonk.

At least 37 records · Page 2Linked to original sources
PubMed1981

Variations in the stromal cell population of human bone marrow during aging.

Age-related variations in the stromal cell population of human bone marrow were studied by means of a cloning assay. It was found that these cells are heterogeneous both in division capacity and in morphology. Fibroblast-like progenitor cells could be distinguished from epithelial-like cells, having only a very limited division potential. A significant inverse correlation between the donor age and the number of progenitor cells could be demonstrated. This loss of progenitor cells during aging was compensated by an increase in the number of epithelial-like cells.

Adolescent↗
PubMed1981

In vitro aging of human bone marrow derived stromal cells.

We have studied the in vitro cellular aging process in human bone marrow derived stromal cells. Two cell types, here called type I and type II, can be distinguished in the primary cell population. During subcultivation, resulting in aging in vitro, the type I cells gradually disappear, whereas the type II cells form an increasing fraction of the population. This observation is confirmed by cloning experiments, revealing that type I cells act as progenitor cells, giving rise to non-dividing type II cells. These results are best explained by the terminal differentiation theory as proposed by Martin et al.

Adult↗
PubMed1981

New possibilities to influence blood lipids and atherosclerosis-proneness with semi-synthetic fats.

Notwithstanding the universally accepted concept that atherosclerosis is a multifactorial disease, our research since thirty years convinced us of the validity of the fat diet theory in the pathogenesis of atherosclerosis. Experiments with semi-synthetic fats enable us to stress the importance of quantitatively and qualitatively modified fat diets, not only in their fatty acid composition, but also in the specific triglyceride structure. Experiences comparing randomized butterfat with natural butterfat and administration of polyunsaturated fatty acid rich fats with monoglycerides, led to comprehensive explanations about the mechanism of monoglyceride assimilation and about the beneficial effect of randomized butterfat in long term experiments.

Arteriosclerosis↗
PubMed1980

Successful pregnancy in an abortion-prone woman: prostaglandin and hormone levels during implantation, gestation and lactation.

Serum progesterone, human chorionic gonadotropin, prostaglandin E2, F2 alpha and 13,14-dihydro-15-keto-PGF2 alpha and urinary immunoractive prostaglandins E2 and F2 alpha were measured throughout gestation in a woman who previously had experienced three abortions, an immature birth of a twin and a term single pregnancy. Prostaglandin-mediated symptoms such as uterine sensitivity and contractions, backache, spotting, vomiting and diarrhea were carefully registered and have been correlated with the variations in prostaglandin levels. The effect of therapy with a prostaglandin synthetase inhibitor and a beta-adrenergic drug on prostaglandin levels was also studied. The rise of prostaglandin E2 level observed during implantation is discussed.

Abortion, Spontaneous↗