Search PubMed⌕ Search

Biomedical subjects

G Vawter

Publications and source records attributed to G Vawter.

23 records · Page 2Linked to original sources
PubMed1975

Malignant lymphoma after diphenylhydantoin (dilantin) therapy.

A history of prolonged diphenylhydantoin (Dilantin) therapy was reported by 8 of 516 patients (1.6%) with Hodgkin's disease or non-Hodgkin's lymphoma, as compared with 3 of 516 patients (0.6%) with other cancers, and 2 of 516 (0.4%) tumor-free individuals. The findings, together with other published data, suggest a small excess risk of malignant lymphomas in patients receiving long-term treatment with this drug. The immunosuppressive effects of chronic diphenylhydantoin therapy may be involved in the pathogenesis of these neoplasms.

Adult↗
PubMed1975

Non-Hodgkin lymphoma of the head and neck in childhood.

A retrospective analysis of pediatric patients with non-Hodgkin lymphoma localized to the head and neck revealed a survival rate of 51.7%. This contrasts with a survival rate of 9% computed from the literature for children with local and regional non-Hodgkin lymphoma in various parts of the body. Major factors influencing survival appeared to be: (1) stage of lymphoma (12 of 17 Stage I survived); (2) histology (7 of 7 patients whose lesions were classified as nodular survived as compared to 5 of 17 with lesions classified as diffuse); and (3) anatomic location. Leukemia developed in seven patients with lesions of the diffuse histologic type. Recent experience suggests that aggressive, integrated treatment with surgery, radiation therapy, ano chemotherapy may favorably alter the course of the disease in patients with unfavorable histologic lesions.

Adolescent↗