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Biomedical subjects

G Vadász

Publications and source records attributed to G Vadász.

At least 19 recordsLinked to original sources
PubMed2000

Hodgkin's disease in the elderly: a single institution retrospective study of 40 patients aged 65 or over.

Out of 485 patients with Hodgkin's disease (HD) treated in our institution between 1970-1998, 40 (8.2%) patients aged 65 or over at the date of the first presentation were examined retrospectively. The localization of the disease was more frequently infradiaphragmatic and rarely mediastinal in the elderly. The time that elapsed from the first clinical sign to the diagnosis of HD was twice as long as that in the young patient population. Since the first treatment was often inadequate and due to severe associated diseases, therapeutic and overall survival results in this patient population were less favourable than in the case of young patients. However, the relapse-free survival rate of the elderly patients treated successfully did not differ from that of the young patient population. Complete healing should be the final aim of treatment in the aged population, while the status of the patient, associated diseases and life expectancy not related with HD should also be taken into consideration. Besides the search for effective and less toxic treatment strategies and supportive therapy, more frequent and overall patient follow-up and care is of great importance.

Aged↗
PubMed1997

Infradiaphragmatic Hodgkin's disease.

Between 1968 and 1994, 133 patients with stages I and II supradiaphragmatic Hodgkin's disease were evaluated at our institution. During the same period we treated only 11 patients with stages I and II infradiaphragmatic Hodgkin's disease. When compared to patients with disease above the diaphragm, patients with Hodgkin's disease below the diaphragm were more frequently male (p < 0.05), were generally older (46.3 vs 40.1 years, but the difference was not significant), had a higher incidence of systemic symptoms (p < 0.05), and had predominantly histologic subtypes with mixed cellularity and lymphocyte predominance. Primary treatment included inverted Y radiotherapy in 3 patients, polychemotherapy in 6, and combined treatment in 2. Ten patients achieved complete response. Five- and ten-year survival rates were 90% and 67.5%, respectively. There was no difference in survival rate between patients with infradiaphragmatic and supradiaphragmatic Hodgkin's disease receiving similar treatment.

Adult↗
PubMed1996

[Secondary lymphomatous polyposis of the gastrointestinal tract in patients with nodal lymphomas].

Multiplex lymphomatous polyposis is an uncommon disease characterized by polypoid accumulations of malignant lymphoid cells within the submucosa of long segments of the gastrointestinal tract. Primary gastrointestinal form of disease is referred as an extranodal variant of the entity knows as mantle zone lymphoma. Rarely, this typical lesion may appear as a secondary involvement of the alimentary tract in patients with primary nodal lymphomas. In present article, the clinical, histological features of our two cases of primary nodal lymphoma presenting with gastrointestinal symptoms and secondary involvement of the bowels are discussed. The nodal lymphomas of these patients were classified as a mantle zone and a follicle center cell origin lymphoma. The development of gastrointestinal symptoms occurred 29 and 41 months after the diagnosis. Our cases suggest that lymphomatous polyposis can manifest itself secondarily in patients with nodal lymphomas of not only the mantle cell type. The polypoid lesion might be mediated by lymphocyte homing receptors and the pattern of proliferation can be produced by more than one phenotypically different lymphoma.

Adult↗
PubMed1994

[Congenital analgesia. Part IV. Adolescence, adulthood, labor (follow-up case report)].

Congenital analgesia in a girl (now woman) is reported for the fourth time. The former reported case is now 27 years old, her pain sensitivity is normal over the entire body. The fourth communication presents her postadolescent and later her young adult life, reporting her two deliveries, producing healthy babies. On the basis of these facts congenital analgesia does not seem genetically determined.

Adolescent↗
PubMed1991

[Congestive gastropathy].

15 patients with congestive gastropathy were reported including clinical and pathological characteristics of the disease. Every patient had alcoholic liver cirrhosis and portal hypertension. 6 patient's stomach was resected while in 2 further cases the disease was found at autopsy. In additional 7 cases the characteristic microvascular changes were observed in endoscopic biopsy specimens from the gastric mucosa. The authors presume that this disease has an acute and a chronic stage. In the acute stage dilated capillaries are present under the surface, not related to the inflammation of gastric mucosa. This phenomenon was described in the literature. In the chronic stage there are dilated and tortuous vessels in the submucosal layer surrounded by collagenous connective tissue. The authors suppose that the thick and fibrotic submucosal layer causes microcirculatory disturbances in the gastric mucosa. The impaired microcirculation may cause extensive ulcers with profuse and sometimes lethal bleeding.

Adult↗
PubMed1989

[Inflammatory giant polyps of the colon].

Five cases of inflammatory giant polyps associated with idiopathic colitis are presented. The underlying disease was ulcerative colitis in 3 cases and Crohn's disease in 2 cases. The alteration caused in 3 cases passage disorders. Physical and X-ray examinations raised the possibility of malignancy, thus operation was performed. In 2 further cases endoscopic polypectomy brought improvement and the operation could be avoided. On the basis of electronmicroscopic examination the authors are of the opinion that giant polyps are specific forms of inflammatory granulation with fibroblasts, myofibroblasts, vessels, mast cells and extended autonomous nerves as dominant elements. It is held as feasible that due to the nerves and contractile myofibroblasts these forms are capable to move actively. This might explain the peduncle formation and - together with the passage disorders- the strong abdominal spasm characterizing the clinical picture.

Adult↗
PubMed1989

Mast cells in ulcerative colitis. Quantitative and ultrastructural studies.

The changes in the number and ultrastructure of mast cells were studied in 37 colonoscopical biopsies from patients with ulcerative colitis. Changes in the active stage of the disease and during remission were compared. Cell counts were performed on semithin sections stained with Giemsa after osmium tetroxide fixation. This method overcome the uncertain staining found after formalin fixation. Accumulation of mast cells accompanied by intense degranulation was found to be significant in the active stage of the disease. Two forms of degranulation were observed: discharge of the individual granules and protrusion and detachment of the cytoplasmic processes containing granules. The latter was a sign of rapid degranulation, as described earlier in animal experiments. Mast cells were closely associated with capillary blood vessels, Schwann cells, neural fibres, myofibroblasts and collagenous fibres, and were also present between epithelial cells. It is assumed that close topographic contact may also imply a functional correlation.

Adult↗
PubMed1989

[Mast cells in ulcerative colitis].

Authors have studied the changes in number and electronmicroscopic appearances of mast cells in the mucosa of large intestine of patients suffering from colitis ulcerosa either in its active or remission period. Counting of cells was performed in osmium-fixed, semithin, Giemsa-stained sections to avoid variations in staining due to formaldehyde. In the active stage of the disease the increase in number of mast cells was significant. Their pronounced degranulation was evident in both semi- and ultrathin preparations. Two forms of degranulation were distinguished: 1. by the release of granules; 2. by the extrusion of whole cytoplasmic areas. The latter indicated fast degranulation, in accordance with observations in animal experiments. Mast cells became closely related to the capillaries, Schwann-cells and nerve fibres of the lamina propria, with myofibroblasts and collagenous fibres. At some places they were found between the epithelial cells of Lieberkühn's crypts. It is assumed that this close topographical correlation represents also functional connections. The present morphological findings corroborate current hypotheses and suggest that the increase in number of mast cells in the active stage of coliitis ulcerosa mediates an hyperergic reaction.

Colitis, Ulcerative↗
PubMed1988

Collagenous colitis: an electron microscopic study including comparison with the chronic fibrotic stage of ulcerative colitis.

Light and electron microscopic studies of 14 cases of collagenous colitis are reported. Comparative electron microscopic examinations were carried out on 13 cases of ulcerative colitis in the chronic fibrotic stage of the disease. Separation of pericryptal fibroblasts which showed enhanced fibre-forming activity, proliferation of myofibroblasts, accumulation of mast cells and a pericapillary collagen accumulation were noted in both groups. Based on these results, collagenous colitis was considered to result from scar formation secondary to previous superficial inflammation.

Adult↗