Search PubMed⌕ Search

Biomedical subjects

G Vacca

Publications and source records attributed to G Vacca.

150 records · Page 9Linked to original sources
PubMedDate not supplied

[Effect of Bunaftine on the aconitine-induced atrial arrhythmias in the dog].

Bunaftine has a quinidine-like vagolytic effect and does not act as a beta-blocking agent. Its effect on aconitine-induced atrial fibrillation in the dog was examined. It led to suproventricular tachycardia in all cases, but re-established the sinus rhythm in only 5/15. It is felt that this lack of success is attributable to the slowing of the frequency of the primary pacemaker on the part of the drug. Slowing down of atrioventricular and intraventricular conduction by Bunaftine was revealed by lengthening of the P-R interval and widening of the Q-RS complex. Decreased blood pressure following administration of the drug appears to be due to reduction of heart rate rather than altered myocardial inotropism or peripheral resistance.

Aconitine↗
PubMedDate not supplied

EEG findings in West syndrome a follow-up of 20 patients.

Clinical and EEG findings of 36 patients with West syndrome (WS) were reported. Twenty patients (7 males, 13 females; mean age 7.4 months at the first EEG examination) were followed for a mean period of 19.3 months. Fifty per cent of the 8 cases with cryptogenic SW showed a full recovery, 2 cases showed persistence of psychomotor retardation or seizures and 2 of both these features. At the end of follow-up period, 92% of the 12 patients with symptomatic WS showed a psychomotor retardation and 75% a persistence of seizures. EEG pattern was a typical hypsarrhythmic one in 11 patients and atypical in the remaining cases. The typical pattern correlated with a better outcome with full recovery in 27.3% compared with 11.1% in the group with atypical EEG. Moreover EEG monitoring was useful for the evaluation of therapeutic response and in the follow-up of the disease, showing a correlation with clinical course, incidence of spasms and outcome.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

Integration between myogenic response and neurovegetative activity in the regulation of the coronary flow.

In the anaesthetized dog a 10 s increase in the coronary perfusion pressure was obtained by constriction of the descending thoracic aorta. At the release of the constriction, the pressure fell abruptly below the control and about 10 s later was followed by a transient myogenic reduction of the coronary vascular resistance. The reduction occurred to about the same extent in the animals with the intact vagi, after vagotomy and after vagotomy plus beta blockade, showing that changes in the basal vasomotor tone do not affect the amplitude of the myogenic vasodilation.

Animals↗