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Biomedical subjects

G V Valueva

Publications and source records attributed to G V Valueva.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Effect of the dopamine agonist parlodel on steroid hormone secretion and their metabolism in the liver].

Experiments on rats have shown that the dopamine agonist parlodel produces a noticeable inhibitory effect on function of the pituitary-adrenal system by a decrease in corticotropin secretion and direct influence on aldosterone synthesis and secretion. Changes in corticosterone level caused by parlodel are related to ACTH action and inhibition of activity of the microcirculatory bed of the adrenal fascicular zone. The dopamine agonist parlodel produces no effect on metabolism of the steroid hormones: corticosterone and testosterone in the rat hepatic tissue.

Adrenal Glands↗
PubMedDate not supplied

[Mechanisms of action of beta-endorphin on the secretion of hypophyseal hormones].

The purpose of the study was to investigate some mechanisms of the effect of beta-endorphin on somatotropic and lactotropic function of the hypophysis, adrenal activity and the content of catecholamines in the cerebral tissues. Activation of the hypophyseoadrenal system, lactotropic and somatotropic functions 5-20 min after beta-endorphin administration was established in experiments on male rats. At the same time a decrease in the content of catecholamines in the hypothalamus, cerebral cortex was observed. It was most significant for dopamine participating in the regulation of ACTH, prolactin and somatotropin secretion.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[Effect of Nakom on the activity of the hypothalamo-hypophyseo-adrenal system].

The effect of nakom, containing the dopamine precursor levodopa, on the activity of the hypothalamo-hypophysial-adrenal system (HHAS), the content of dopamine in the hypothalamus and the cerebral hemisphere cortex and cAMP in tissues, was studied in experiments on rats. It was revealed, that the preparation in the 2 mg per 100 g dose has a marked inhibiting action on the activity of the HHAS, that is expressed in 2 h by the drop of the level of ACTH, corticosterone, aldosterone in blood that is maintained for 10 hours and disappears 24 hours after the administration. One of the possible mechanisms of the inhibiting action of the preparation on HHAS activity is the increase of dopamine content in the hypothalamus and cerebral hemisphere cortex. The inhibiting action of the preparation on HHAS activity is dose-dependent. The inhibiting influence of nakom on the HHAS activity is realized through the adenylate cyclase system.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Experimental and clinical basis for using the preparation nacom in the treatment of Itsenko-Cushing disease].

The paper is concerned with the results of an experimental study of the nacom (NC) effect on the activity of the hypothalamohypophysioadrenal system and the results of its application to 29 patients with Icenko-Cushing's disease with curative purposes. In rats the concentration of corticotropin and aldosterone was determined with a radioimmunoassay, that of corticosterone with a competitive protein binding method. The dopamine content in the hypothalamus and cerebral cortex was studied by fluorimetry. To define the hypothalamohyphysioadrenal system in the patients a study was made of blood corticotropin, cortisol and aldosterone basal levels as well as response of the system to insulin hypoglycemia induced stress. Dopaminergic NC was shown to be dose-related with the activity of the hypothalamohypophysioadrenal system. The NC effect was associated with an increase in the dopamine level in the hypothalamus and cerebral cortex. Clinical investigations proved NC efficacy for therapy of Icenko-Cushing's disease permitting one to recommend it as a pathogenetic agent for therapy of this disease.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[The metoclopramide test in the differential diagnosis of various forms of galactorrhea-amenorrhea syndrome].

The results of the metoclopramide test in 24 patients with the lactorrhea-amenorrhea syndrome were presented. It was shown that the metoclopramide test could be used for differential diagnosis of various types of disease. The blood prolactin concentration was raised only in the patients with the functional type of the lactorrhea-amenorrhea syndrome and changed insignificantly in the patients with pituitary microadenoma as well as in the patients with a noticeable increase in the prolactin basal level but without x-ray signs of a pituitary tumor. The presence of pituitary microadenoma could be suspected in the patients of the 3rd group.

Adenoma↗
PubMedDate not supplied

[Characteristics of the action of parlodel on endocrine functions of the body].

The effect of dopamine agonist parlodel (1 and 5 mg/kg) on the activity of the hypothalamic-pituitary-adrenal system, lactotropic and somatotropic pituitary functions was studied. The content of ACTH and corticosterone in the blood and tissue, aldosterone in the blood, prolactin, somatotropic hormone in the pituitary, catecholamines in the hypothalamus and cerebral cortex demonstrated the inhibitory effect of the drug on the functioning of the hypothalamic-pituitary-adrenal system, and pituitary, lactotropic and somatotropic functions. The mode of parlodel action consists probably in the decrease of turnover rather than in any changes of dopamine and catecholamine content in the hypothalamus and cerebral cortex. Parlodel failed to affect steroid metabolism in the body.

Animals↗
PubMedDate not supplied

[Dynamics of secretion of hypothalamo-hypophyseal system hormones in Itsenko-Cushing disease as affected by combination therapy].

The results are presented of the studies on corticotropin, cortisol, beta-lipotropin, beta-endorphine, somatotropin, somatostatin, prolactin and thyrotropin secretion in 46 patients with active Icenko-Cushing's disease at the nearest and late periods after the treatment with an antiserotonin drug--cyproheptadine (peritol) combined with an adrenocortical secretion inhibitor--khloditan. The hormone basal levels and secretion under the action of stress, induced by insulin hypoglycemia or thyroliberin injection, were determined in the patients under examination by radioimmunoassay. In patients with an acute stage of the disease the blood beta-lipotropin, beta-endorphine, corticotropin, cortisol, somatostatin and prolactin concentrations are elevated, whereas those of somatotropin and thyrotropin are lowered. The hypothalamic, hypophyseal and adrenocortical response to stress or thyroliberin injection is reduced. THe combined treatment with khloditan and high doses of cyproheptadine led to pronounced clinical and hormonal remission in 55% of the patients. The blood beta-lipotropin, beta-endorphine, corticotropin, cortisol, somatostatin and somatotropin concentrations returned to normal. The blood prolactin and thyrotropin levels, as well as the response to thyroliberin injection remained disordered.

Adolescent↗
PubMedDate not supplied

[Neurotensin in Itsenko-Cushing disease].

The results are presented on studying the blood neurotensin concentration in 68 patients with Icenko-Cushing's disease and in 5 persons with adrenocortical tumors. Neurotensin fasting content was determined by radioimmunoassay after insulin, glucose, peritol and parlodel administration and following the treatment with chloditane-, chloditane-cyproheptadine complex, a combination of chloditane and a dopaminergic drug. It was found that the blood neurotensin concentration is enhanced in the active stage of Icenko-Cushing's disease. Marked changes were not observed in the blood neurotensin concentration of healthy subjects and patients with Icenko-Cushing's disease under stress, provoked by insulin hypoglycemia and after glucose injection. Different sensitivity to peritol and parlodel was seen in a half of patients with an increased blood neurotensin concentration. During clinical remission of Icenko-Cushing's disease under chloditane and combined chloditane-peritol treatment the blood neurotensin level returned to normal, remaining increased in patients treated with chloditane and a dopaminergic drug.

Adolescent↗
PubMedDate not supplied

[Potential use of the antiserotonin preparation cyproheptadine (peritol) in Itsenko-Cushing disease].

Experiments on male rats have shown that the inhibitory effect of peritol on the hypothalamohypophyseal-adrenal system (HHAS) is determined both by its influence on the regulatory mechanisms of the CNS and direct action on secretion and, possibly, synthesis of steroids. The degree of the antiserotonin and the HHAS-inhibiting effects depends on the frequency of drug administrations rather than on its dose. The experimental studies made it possible to successfully apply peritol to the treatment of inpatients suffering from Icenko-Cushing's disease. Almost 60% of the inpatients manifested a remission, which was confirmed by the reduced blood content of ACTH, hydrocortisone and aldosterone.

Adolescent↗
PubMedDate not supplied

[Changes in the functional state and ultrastructure of the cells of the zona glomerulosa of the rat adrenal cortex under prolonged immobilization stress].

Experiments were conducted on male rats aged from 45 to 50 days; during the development of the general adaptation syndrome distinct functional and ultrastructural shifts originated in the adrenal cortex glomerular zone at the early and end stages of the reaction pointing to the intensification of biosynthesis and of aldosterone secretion. At the early periods (immobilization for 30 min) increased adrenocorticosteroid activity was conditioned by factors influencing the early stages of steroidogenesis, chiefly by corticotropine. Aldosterone biosynthesis and secretion stimulation after 72 hours of immobilization was connected with the activation of the renin-angiotensin system, and, possibly, with factors influencing the end stages of steroidogenesis.

Adrenal Cortex↗
PubMedDate not supplied

[Age and features of the functional activity of the thyroid gland in experimental hypocorticism].

Data are presented on age peculiarities of the functional activity of the thyroid gland, thyrotropic function of the hypophysis, transport forms of thyroid hormones, and tissue thyroxin saturation in experimental hypocorticism in rats. Investigations were conducted on albino male rats of three age groups--1 1/2-2, 8-10, 28-32 months old. The changes which took place in rats of different age after adrenalectomy were in the same direction, but unequal in different links of the thyroid gland regulation of metabolism and its function. These changes were expressed in reduction of the thyrotropic function of the hypophysis, of the secretory activity of the thyroid gland, of the thyroxin-binding capacity of the blood serum, and of the tissue thyroxin saturation. With the advance of age there was a marked decrease in the reaction capacities of the functional link of the hypophysis and the thyroid gland tissue, but not in the tissues.

Adrenal Insufficiency↗