Biomedical subjects
Publications and source records attributed to G V Tiuleneva.
The authors describe the dynamics of circulating immune complexes and indices of kallikrein-kinin system in the dynamics of the disease and convalescence period of patients with viral hepatitis B. A relationship was established between indices of the kallikrein-kinin system and their prognostic significance in the formation of unfavourable outcomes of the disease.
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The paper is concerned with the experimental data on a ERP signal size in two blood plasma metalloproteins--ceruloplasmin and transferrin and their correlations after intraperitoneal hydrocortisone and corticotropin injections (5 mg and 2.5 U/100 g body weight, respectively) to Wistar adult male rats and after bilateral adrenalectomy. A conclusion has been made that antioxidant activity of the ceruloplasmin-transferrin complex in rat blood plasma is increased with a rise of the corticotropin level but it is decreased with hydrocortisone loading.
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The influence of histones, protamine, pronase E and albumin on the corticosterone amount in the blood of rats has been studied. It is shown that injection of 10 and 100 (or 500) mkg of histones per 100 g of body weight leads to a decrease of the corticosterone amount in the blood 24 and 5 h (respectively) later. Irrespective of the injection way (intra-abdominal or per os), a dose of 500 mkg of histones per 100 g of body weight decreases the corticosterone amount in blood by 96%, already 5 h later and, after 24 h the corticosterone amount is practically undetermined. In all cases regeneration of the corticosterone amount in blood is observed after 48 h, and besides, the regeneration extent is inversely proportional to the extent of the corticosterone amount decrease in the first hours of the histone injection. After digestion of 500 mkg of histones with 10 mkg of pronase E during 10 min at 37 degrees C and following injection of this mixture, the corticosterone amount in blood decreases but to much less extent than with injection of the same quantity of intact histones. After more intensive digestion (500 mkg of histones with 50 mkg of pronase E during 30 min at 37 degrees C), histones do not decrease the corticosterone amount in blood but they increase it 5 h after the injection, and then exert no influence on the corticosterone amount. The protamine injection does not influence the corticosterone amount in the first hours but increases it 48 h later. Injection of pronase E and albumin increases the corticosterone amount in blood.(ABSTRACT TRUNCATED AT 250 WORDS)
It has been shown that the administration of total histones (H1, H3, H2B, H2A, H4), the total histones without histones H4 (H1, H3, H2B, H2A), H1 histones at concentrations of 0.001 and 1 microgram per 100 g of body weight (low and high concentrations) to intact rats during 6 days leads to the decrease of T4 amount in the blood plasm. The total histones and histone H1 at low concentration decrease the T4 amount by the coefficients 5.2 and 5.8 respectively. The corresponding coefficients for high concentration are 2.6 and 1.2. There is no difference in the action of the total histones and H1 histone at low concentration. Low concentration of histones is more effective for the decrease of T4 amount than the high one or than the antithyroid agents mercasolyl and LiCl (3 mg and 2 mM per .100 g of body weight), which decrease the amount of T4 in intact rats by the coefficient 3.6 in 38 days. Administration of histones decreases the amount of T4 in the intact rats but, on the contrary, the 3-4 fold increase is observed in hypothyroid rats, so the amount of T4 is practically reverted to the level of intact rats. The mechanism of regulation of the amount of T4 by histones is discussed.
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