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Biomedical subjects

G V Mann

Publications and source records attributed to G V Mann.

At least 37 records · Page 2Linked to original sources
PubMed1977

Diet and obesity.

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Adipose Tissue↗
PubMed1977

A factor in yogurt which lowers cholesteremia in man.

Large dietary intakes of yogurt are found to lower cholestermia in man. This effect is associated with a reduction of incorporation of radioacetate into serum cholesterol. The effect appears slowly and persists after intake of the yogurt stops suggesting that the mechanism involves the synthesis of a regulatory protein rather than an allosteric effect. The effective agent is postulated to be hydroxymethyl glutarate which inhibits the regulatory enzyme hydroxymethyl glutaryl CoA reductase (EC 1.1.1.3.4).

Adult↗
PubMed1977

A factor in milk which influences cholestermia in rats.

Rats fed cholesterol show an adaptive response over several weeks with lowering of the initial rise of choleseremia to near normal levels. This reducation of cholesteremia is augmented by including milk powder in the diet. A similar effect is obtained by feeding 0.1% beta-hydroxy-beta-methylglutaric acid (HMG) in the diet. The evidence suggests that milk powder contains HMG.

Animals↗
PubMed1975

The membrane transport of ascorbic acid.

A system for measuring the rate of transport of dehydroascorbate into human red blood cells shows Michaelis-Menten type kinetics with substrate inhibition at levels above 150 muM DHA. The addition of sugars impairs this transport in the diminishing hierarchy D-glucose, D-mannose, D-xylose, D-galactose, L-lyxose, D-araboascorbate, L-sorbose and 2-deoxy-D-ribose. The effect of glucose on transport of ascorbate is marked at physiological levels. Transport of DHA is accelerated by copper ion and allows dehydroascorbate to move against a concentration gradient. The evidence supports the hypotheses proposing that hyperglycemia will impair the intracellular availability of vitamin C.

Adult↗