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Biomedical subjects

G Ungvári

Publications and source records attributed to G Ungvári.

At least 19 recordsLinked to original sources
PubMed1986

[Some problems of genetic counseling in schizophrenic psychoses].

The authors sum up the most important basic principles of diagnostics and genetics of the schizophrenic psychoses from the viewpoint of genetic counseling for the practising psychiatrist and medical geneticist. Regarding genetic counselling strategy, in addition to nosological considerations, they stress the importance of socio-cultural and social psychological factors and of the emotional atmosphere in the family, which should all be taken into account together. Because of the special situation of schizophrenic (and in general, psychiatric) patients and their families, they regard it as advisable to set up a separate psychiatric genetic counselling service.

Genetic Counseling↗
PubMed1986

Pimozide treatment for delusion of infestation.

Pimozide was tried in the treatment of delusion of parasitosis (a type of monosymptomatic hypochondriacal psychosis), a syndrome that is found with increasing frequency. Ten patients were selected on the basis of unambiguously defined psychopathological criteria. Pimozide therapy was assessed by means of placebo control and the double-blind method using a rating scale evolved for this particular therapy. The results have quite definitely proved the effect of small doses (two to eight mg per day) of pimozide compared to the administration of a placebo. The very few side-effects observed could easily be influenced. The dynamics of the regression of the psychopathological symptoms suggest that the efficacy of pimozide therapy is decisively linked to the central dopamine receptor blocking effect of the drug.

Aged↗
PubMed1986

Comparative multiple threshold analysis: a possible new way for validating schizophrenia classifications.

Activ. nerv. sup. (Praha) 28, 2. 1986. 350 carefully selected schizophrenic probands and their parents and siblings were diagnosed according to three different clinical classifications and a multiple-threshold analysis was carried out within the framework of the multifactorial model of inheritance. The results suggest that of the three classificatory systems studied, Leonard's and Sneshnevsky's nosological system delineate relatively homogeneous subtypes from the clinical and genetic point of view, pointing to the promise these nosological systems have for the planning of future research in psychiatric genetics.

Evaluation Studies as Topic↗
PubMed1985

A contribution to the validity of Leonhard's classification of endogenous psychoses.

The author made a clinical-genetical study of the schizophrenias and cycloid (schizoaffective) psychoses following the Leonhardian classification, using the traditional pedigree analysis and multiple threshold method. According to the latter method--on the basis of phenotypical correlations--the systematic schizophrenias could be clearly distinguished from the cycloid psychoses, while the non-systematic category presumably occupies a genetical position between the two former categories.

Adolescent↗
PubMed1985

[Comparative clinicogenetic study of schizophrenic psychoses].

The author diagnoses 350 carefully selected schizophrenic subjects, their parents and their siblings during parallel studies using three different clinical classification systems and analyzes the results by multiple threshold analysis and the multifactorial inheritance model. The results suggest that, of the three classifications the author studied, Leonhard's and Sneshnewski's system yield relatively homogeneous subgroups; this indicates the future significance of these nosological systems for the planning of biopsychiatric research.

Adult↗
PubMed1985

[Clinicogenetic studies within the scope of Leonhard taxonomy].

Using conventional genealogical methods and genetic correlation analysis, the author investigates Leonhard's classification of schizophrenias and cycloid psychoses. According to the second of these methods, the systematic schizophrenias and cycloid psychoses definitely diverge on account of the phenotypic correlations, whereas the unsystematic group presumably occupies a median genetic position between the two categories first mentioned.

Adult↗
PubMed1984

[Treatment of a dermatozoon delusion with neuroleptics].

The author treated as inpatients or outpatients a total of 26 individuals with typical acarophobia syndrome, using neuroleptics, mainly Pimozid/Orap. His results have shown that neuroleptics are drugs with rapid and pronounced action in acarophobia and that they have a syndrome-specific profile. The author presents the theoretical and practical consequences of his experiences in connection with this mode of treatment.

Aged↗
PubMed1984

Comparative genetical analysis: a new tool for validating the schizophrenia subtypes.

350 carefully selected schizophrenic probands and their parents and siblings were diagnosed according to three different clinical classifications, and a multiple-threshold analysis was carried out within the framework of the multifactoral model of inheritance. The results suggest that of the three classification systems, Leonhard's and Sneshnevsky's nosological system delineates relatively homogeneous subtypes from the clinical and genetic point of view, pointing to the promise these nosological systems have for the planning of future research in psychiatric genetics.

Genetics, Behavioral↗
PubMed1983

Validity of the ICD-9 schizophrenia classification. A blind family history study.

Within the framework of the multifactorial-polygenic model of inheritance, multiple threshold strategy was applied to a large set of pedigree data to examine the clinico-genetical position of some subtypes within the ICD-9 classification of schizophrenic psychoses. It appeared highly probable that the ICD-9 subtypes examined, based mainly on the classical Kraepelin-Bleulerian classification (simplex, hebephrenic, catatonic, paranoid, schizo-affective) are not homogeneous from the clinico-genetical point of view and genetical factors cannot be held primarily responsible for the clinical differences between the subtypes.

Adolescent↗
PubMed1982

[Not Available].

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Disease↗
PubMed1981

Clinical notes on the possible anticholinergic reversal of depressive syndromes.

The authors report on the effects of acute confusional states and deliria (pharmacogenic confusional syndromes - PCS), occurring under the influence of psychotropic drugs on the depressive syndrome of three patients. The favourable influence of PCS on the depressive syndrome is considered to be largely linked to the anticholinergic effect of the drugs. The observations made in these three patients may give support to the hypothesis that cholinergic activity has pathogenic significance in depressive syndromes.

Depressive Disorder↗
PubMed1981

[Neuroleptic large dose therapy of schizophrenias].

In recent years, the complex treatment of schizophrenia has been extended by the neuroleptic large-dose therapy. Our investigations carried out so far, which reflect the experiences gained in several years with this form of treatment, include 30 schizophrenic patients admitted in an acute psychotic condition. They were treated for six days running with 40 to 120 (average 65) mg of Haloperidol daily. The results of our studies show that the large-dose therapy with Haloperidol as an initial phase of a combined pharmaco-therapy represents a safe, rapid and effective method.

Acute Disease↗