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Biomedical subjects

G Uhlschmid

Publications and source records attributed to G Uhlschmid.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Cardiovascular diseases after kidney transplantation: an analysis of predisposing factors].

Out of 512 recipients of kidney allotransplants 36 patients exhibiting cardiovascular complications (coronary artery disease, cerebrovascular accident, aneurysm of aorta, peripheral arterial occlusions) were compared with an age and sex matched group of recipients without cardiovascular problems. The following significant differences were observed in the study group versus the controls: high systolic and diastolic blood pressure, longer duration of hypertension before renal allografting, higher serum concentrations of cholesterol, triglycerides and uric acid, and an increased incidence of left ventricular hypertrophy and preexisting cardiovascular disease. No differences were found between the two groups as regards smoking habits, overweight, hyperparathyroidism, duration of hemodialysis treatment and type of kidney disease. Diabetes mellitus, family history of cardiovascular complications and hypertonic alterations of the eye fundus were more frequent, but not to a statistically significant extent, in the study group as compared to control patients. These findings show the need for regulation of blood pressure, hyperlipemia and hyperuricemia to ensure successful longterm rehabilitation after kidney allografting.

Cardiomegaly↗
PubMed1981

[Progress in human pancreas transplantation (author's transl)].

Between July 1980 and March 1981, 7 simultaneous pancreas and kidney transplants were performed in patients with juvenile diabetes and renal insufficiency. A duct-occluded (Prolamine) segmental pancreas was placed into the peritoneal cavity with vascular anastomoses to the left iliac vessels. Three transplantations were unsuccessful because of a damaged transplant, and one was lost because of venous thrombosis. Three patients with a maximal follow-up of 9 1/2 months have normal blood sugar despite lack of exogenous insulin and despite prednisone intake.

Adult↗
PubMed1981

[The pathogenesis of stomach wall necrosis following selective proximal vagotomy].

Six patients with necrosis of the lesser curvature of the stomach after proximal selective vagotomy are described. The decreased circulation due to proximal selective vagotomy can lead to extensive necrosis of the lesser curvature in cases of lack of submucosal plexus, and especially in cases with stenotic arteriosclerotic collaterals. However, one must differentiate localized perforations caused by a intraoperative laceration of the gastric wall and perforations of a gastric ulcer. Renal insufficiency, hypertension, diabetes mellitus, generalized arteriosclerosis, and previous splenectomy are, in our experience, contraindications for a proximal selective vagotomy. Those cases should be treated by selective gastric vagotomy with pyloroplasty.

Adult↗
PubMed1980

[Results of curative, distal resection of stomach neoplasms].

Between 1962 and 1971 there were operated 99 patients suffering from gastric cancer. From these, 83% could be controlled as long-term follow-up. The overall survival rate after one year was 68%, after three years 40% and after five years 36%. The patients with tumor-free lymph nodes showed a 5-year survival rate of 49% while of those with tumor-involved lymph nodes only 17% lived longer than five years. The survival rate, especially of older patients (above 60 years), showed with a distal gastric resection compared to a total gastric resection a significant lower postoperative mortality, a better quality of life and a better survival rate. A total gastric resection should only be indicated in cases in which a radical tumor resection could not be realized with a distal gastric resection.

Adenocarcinoma↗
PubMed1980

[Experience with the EEA stapler in colon anastomosis].

On the basis of 35 resections of the sigma of low anterior resections of the rectum, the outcome of conventional (13) and EEA stapler (22) anastomoses is analysed. The incidence of clinical or radiological insufficiencies is significantly lower in stapler anastomoses. Technical details important for a successful stapling procedure and the outcome of the anastomosis are discussed. The importance of the control for completeness of the tissue rings after removal of the purse-string suture is stressed. Regarding these technical details stapler anastomoses have proven to facilitate very low anterior rectal resections and to achieve less postoperative complications.

Aged↗
PubMed1980

[Late results after total gastrectomy and reconstruction by the Hunt-Lawrence-Ròdino method].

The operative technique to perform the jejunal pouch--a stomach substitute--according to Hunt-Lawrence-Rodinò is described. This operation should be employed in all cases in which a radical procedure is under consideration. The quality of life is much better than after simple esophago-jejunostomy. The 5-year survival after gastrectomy for carcinoma being 37% and 50% for Zollinger-Ellison syndrome, respectively, a somewhat longer operation is justified.

Gastrectomy↗
PubMed1978

[Side effects of proximal selection vagotomy on the esophagus. I. Effects on the esophageal blood circulation (author's transl)].

The influence of the proximal selective vagotomy (PSV) with following skeletisation of parts of the esophagus on its circulation was investigated in an animal experimental study. Among the 6 dogs with PSV and skeletisation of the esophagus up to the upper thorax apertura one was seen with necrosis and perforation in the distal part of the esophagus. The last 5 dogs and the 4 dogs in which after the PSV only the denudation of the distal part of the esophagus was carried out no signs of circulatory disturbance were seen. The blood circulation in human esophagus, as described in the literature, and the transfer of the results from dogs to human is discussed. An enlarged skeletisation of the esophagus in order to improve the completeness of the PSV does not harm blood circulation.

Animals↗
PubMed1978

[Prolonged renal graft survival induced by blood transfusion (author's transl)].

All renal allotransplants performed at the Cantonal Hospital, Zurich, in 1975 and 1976 were analysed with respect to pre-transplant blood transfusions, excluding secondary transplants, patients on dialysis outside of Switzerland, combined renal and pancreatic transplants, and women with previous pregnancies but without transfusions. Among 72 patients left for analysis there were 16 who had never received any pre-transplant blood transfusion. Their graft survival was much worse (one-year graft survival 36%) than that in patients with previous transfusions (one-year graft survival 70--80%). Patients without previous blood transfusion should, therefore, no longer be admitted for renal transplantation.

Blood Transfusion↗
PubMed1978

[Pancreatitis following kidney transplantation].

Follow-up of 249 recipients of cadaver renal allografts revealed 14 cases of pancreatitis. The minimum follow-up time was 2 1/2 years and the maximum 12 1/2 years. In 9 patients acute pancreatitis occurred within 4 months, 5 died from hemorrhagic-necrotizing disease. Later, 2 lethal cases of abscess-forming pancreatitis, 1 benign acute and 2 chronic forms were observed. The mortality in post-transplant pancreatitis is 7 out of 14, which corresponds to 7% of all fatalities after transplantation. Many different factors contribute to the development of pancreatitis, the most important being steroid medication.

Acute Disease↗
PubMed1978

[Revitalization of bovine xenograft used for repair of experimental tracheal defects (author's transl)].

In 12 mongrel dogs tracheal defects of different size were covered by bovine xenografts. The grafts were subjected to electronmicroscopic examination 2 to 19 months after implantation. Following the ingrowht of fibroblasts and capillaries a basal membrane is formed on the side of the previous graft lumen. After 4 to 5 months this membrane is covered from the tracheal margins by microvillous cells. After 8 months ciliated epithelia and goblet cells are developed by cell metaplasia. Although the graft becomes revitalized and integrated into the tracheal wall, the layer of ciliated epithelia is interrupted by less differentiated cells. The possible causes for this phenomenon are discussed. Thus bovine xenograft used for the repair of tracheal defects has the following advantages: total revitalization, no shrinkage, less prone to infection and formations of ciliated epithelia.

Animals↗
PubMed1978

[Revitalization of bovine xenografts used for experimental arterial replacement in dogs (author's transl)].

In 16 mongrel dogs bovine xenografts of 4 to 12 cm of length were used for arterial replacement. The grafts were removed after 30 minutes and up to 13 months for electronmicroscopic examination. The graft was shown to be significantly thrombogenic during the first six weeks after implantation. After 8 to 10 weeks an increasing revitalization of the graft is found starting from the ends of the canine artery. A cover of endothelial cells is formed in the graft lumen. The graft wall is enforced by formation of collagen and elastic fibers originating from capillaries and fibroblasts. Revitalization of the graft is limited to a rim of 2 to 3,5 cm next to the anastomoses with the canine artery. The remaining graft segment shows revitalization only on the outside wall. Degenerative changes take place in the inner layer of the graft with time passing.

Animals↗