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Biomedical subjects

G Turpin

Publications and source records attributed to G Turpin.

248 records · Page 14Linked to original sources
PubMedDate not supplied

[The study of the influence of prolactin on gonadal steroids metabolism by the human chorionic gonadotropin test. Plasma and urinary determinations in 27 subjects (control, hyperprolactinemic, normoprolactinemic but hypogonadic subjects) (author's transl)].

In order to determine whether hyperprolactinemia besides its action at the hypothalamic level, acts at the gonadal level, a serie of 28 stimulations by Human Chorionic Gonadotropin (HCG : 5 000 IU X 3) is reported. The following parameters were measured in plasma and in urine before and during 4 consecutive days following the injection of HCG : Progesterone (P), 17 OH Progestérone (17 OHP), Androstenedione (A), Testostérone (T), Dihydrotesterone (DHT), Estrone (E1), 17 beta estradiol (E2), Urinary Androstanediol (Adiol) Testosterone Glucuronide (G.T.) and phenolsteroids (PS). The test was performed in both sex, in 3 different groups including normal, hyperprolactinemic and normoprolactinemic but hypogonadic subjects (hypopituitarism). These data suggest that in hyperprolactinemic subjects: there is no steroid 5 alpha reductase abnormality in male patients, and there is no gonadal resistance to HCG stimulation in both sex, at least to the high doses of HCG used in this study.

Chorionic Gonadotropin↗
PubMedDate not supplied

[Determination of 6 pituitary hormones in the cerebrospinal fluid. Control subjects, prolactin adenomas, empty sella syndrome and hypothalamic disorders (author's transl)].

Cerebrospinal fluid (CSF) and serum concentrations of TSH, ACTH, FSH, LH, GH and PRL were measured simultaneously in 34 subjects divided into 3 groups: I-12 normal subjects (6 males and 6 females); II-12 prolactin adenomas (3 males and 9 females); III-5 empty sella syndromes, 3 hypothalamic disorders, 1 chromophobe adenoma, 1 pituitary dwarfism. It is concluded that: 1) pituitary hormones are the normal constituents of CSF but the level can be undetectable and in any case lower than the serum level. 2) there is a positive correlation between serum and CSF concentration of PRL when serum PRL is higher than 20 ng/ml, indicating that the CSF level is influenced by serum level. 3) in prolactin adenomas, only prolactin is elevated in the CSF. 4) there is no correlation between the high level of CSF-PRL and a suprasellar extension of the adenoma.

Adenoma↗
PubMedDate not supplied

[Intrasellar chordoma (author's transl)].

The authors present two cases of intrasellar chordoma and review these tumor's most important characters. This intrasellar localization seems to be very rare. Endocrinological disorders, when observed, leads only to insfufficiency and never to hypersecretion. Final diagnosis is established by histological studies. Their volume is important, so that the recurrence after surgery is common and the middle term prognosis is bad.

Adult↗
PubMedDate not supplied

[Determination of pituitary hormones in cerebrospinal fluid in normal subjects and in hypothalamo-pituitary diseases. Secreting or non-secreting pituitary adenoma, empty sella syndrome, hypothalamic syndromes].

Cerebrospinal fluid (CSF) and serum concentrations of TSH, ACTH, FSH, LH, GH and PRL were measured simultaneously in 34 subjects divided into 3 groups: I--12 normal subjects (6 males and 6 females); II--12 prolactin adenomas (3 males and 9 females); III--5 empty sella syndromes; 3 hypothalamic disorders; 1 chromophobe adenoma; 1 pituitary dwarfism. It is concluded that:--pituitary hormones are the normal constituents of CSF but the level can be undetectable and in any case lower than the serum level; --there is a positive correlation between serum and CSF concentration of PRL when serum PRL is higher than 20 ng/ml, indicating that the CSF level is influenced by serum level; --in prolactin adenomas only prolactin is elevated in the CSF; --there is no correlation between the high level of CSF-PRL and a suprasellar extension of the adenoma.

Adenoma↗
PubMedDate not supplied

[Management of dyslipidemia].

There is now an enormous amount of literature on the relationship between blood lipids and coronary artery disease. It is clear that the treatment by modification of the diet and hypolipidaemic drugs is associated with a decrease of the coronary events. However there is no cure for any of the primary dyslipidemias and relative treatment involves a life-long commitment by the patient. In addition the efficiency of the treatment is dramatically different in patients at very high risk (secondary prevention, combination of several risk factors) and in those at moderate risk. Furthermore, patient's compliance is usually low. Therefore management of the hyperlipidaemic patients requires a rigorous approach to evaluate the global risk and consequently to adapt the treatment at an individual level. We describe here our outpatient clinic in which about 6000 hyperlipidaemic patients have been referred. We indicate the strategy that we used for taking care the patients including 1) the education of the subjects 2) the detection of secondary hyperlipidaemia 3) the evaluation of the global risk including non-invasive evaluation of the atherosclerosis and the results of such approach (for example, we found a much higher percentage of positive exercise ECG in patients with carotid atherosclerosis in our ultrasonographic examinations.

Arteriosclerosis↗
PubMedDate not supplied

[Brakes and levers of mobilization concerning cardiovascular prevention].

It is widely known that epidemiological studies have identified several major cardiovascular risk factors, such as hypertension, smoking, diabetes mellitus, and hypercholesterolaemia. It is also widely known that the management of these factors leads to a reduction of cardiovascular morbidity and mortality, and the benefit on global mortality has been demonstrated very recently. It is relatively easy to ensure effective secondary cardiovascular prevention, as the patients are generally fairly motivated, but it is much more difficult to ensure effective primary prevention, as the subjects concerned are in good health and need to be convinced of the value of preventive measures. Primary prevention must be based on better information of patients and physicians, warning them against certain denigration campaigns, such as those designed to minimize the role of lipid abnormalities in the pathogenesis of atherosclerosis and to falsely reassure our countrymen with the famous French paradox. This discussion concerning the difficulty and importance of primary cardiovascular prevention concludes with several concrete proposals.

Adolescent↗
PubMedDate not supplied

Mild liver abnormalities associated with elevated plasma factor VII and protein C in hypertriglyceridaemic patients.

OBJECTIVES: It is now well established that not only atheroma, but also thrombosis play a key role in coronary heart disease. High levels of some haemostatic parameters, which increase the risk of thrombosis, are often associated with lipid abnormalities. The mechanism by which patients with hyperlipidaemia display an increase in some haemostatic parameters remains to be established. Therefore, in this study, we measured factor VII antigen and its clotting activity as well as protein C-activity in a population of patients who had been referred to us for hyperlipidaemia. METHODS: We carefully selected a population of 130 healthy asymptomatic males. The study population consisted of patients aged 45.5 +/- 12.3 years with mean (+/- SD) levels of cholesterol and triglycerides of 2.60 +/- 0.58 g/L and 1.82 +/- 1.95 g/L, respectively. RESULTS: We found higher levels of plasma factor VII activity, antigen and protein C activity in patients displaying hypertriglyceridaemia. In a univariate analysis there was a significant and positive correlation between these coagulating factors and the hepatic enzymes. In a multivariate analysis the three parameters which could significantly account for the variation of factor VII antigen were age, hepatic enzyme and triglyceride concentrations whereas only triglyceride levels were associated with factor VII activity; The parameters associated with protein C levels were the concentration of the hepatic enzymes and the levels of serum triglycerides. CONCLUSIONS: We suggest that mild liver abnormalities such as steatosis may be one of the factors which can lead to an increase in factor VII and protein C levels.

Adult↗
PubMedDate not supplied

[Ischemic cardiovascular accidents during treatment with progestins alone. Apropos of 3 cases].

Three cases of ischaemic cardio-vascular accidents are reported under progestative treatment; the drug used was chlormadinone acétate (0,5 mg daily) in one patients, and noréthistérone (5 mg daily) in two others. The accident was observed in two cases at the end of the second menstrual cycle and in one case after three years. Lipid abnormalities have been detected in the three cases: minor type IV (two patients) and mixed hyperlipidaemia (one patient).

Adult↗