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G Tscherne

Publications and source records attributed to G Tscherne.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Results of the treatment of trophoblast tumours (author's transl)].

Within 10 years 24 patients were treated for choriocarcinoma. Experience with new methods of diagnosis, treatment and followup was gained. 11 patients were considered to be in a low risk group and 13 patients were categorized as high risk patients. The treatment was primarily conservative. Patients with low risk received single treatment with methotrexate. In some cases in the high-risk group combination chemotherapy or polychemotherapy was used. In addition to the clinical findings, the results of the treatment are monitored with serial beta HCG determinations. Of the 11 patients in the low-risk group all well and free of recurrence. Of the high-risk group 6 patients died. Of the total of 24 patients with choriocarcinoma 18 (75%) are well and free of recurrence.

Chorionic Gonadotropin↗
PubMed1979

[Amenorrhoea and hyperprolactinaemia (author's transl)].

Prolactin was determined by radioimmunoassay in the serum of 112 patients with primary or secondary amenorrhoea. 21 cases showed hyperprolactinaemia with levels above 25 ng/ml (18.7%). 10 patients with levels between 25 and 50 ng/ml showed heterogeneous clinical features. In nine women (8%) the prolactin level was above 100 ng/ml; they all had severe amenorrhoea. As a result of treatment with bromocriptine menstrual bleeding occurred in 4 out of 7 cases and 2 of these patients became pregnant. In 3 cases prolactin did not return to normal levels and in 2 out of these patients microadenomas of the pituitary gland were diagnosed by special methods. They were removed surgically by the transsphenoidal approach.

Adenoma↗
PubMed1979

Limits of therapy for malignant chorioepithelioma.

Report on two cases of malignant chorio-epithelioma following hydatidiform mole, both decreased 4 years after inception of the disease despite initially successful therapy and repeated remissions. In the first case a solitary pulmonary metastasis showing obvious de-differentiation and extensive local reparative processes was removed operatively. Associations to cytostatic medication are discussed. The second case was characterized by unusually extensive chronic pulmonary embolism with highly regressive choriocardinomatous aggregates. Death resulted unexpectedly from chronic dextrocardial insufficiency. It is stressed that the treatment is subject ot limitations of not only relative (i.e., resistance to cytostatics, inadequate treatment etc.) but also of an absolute nature, as in case 2.

Adult↗
PubMed1979

[New aspects of diagnosis, treatment and follow-up of trophoblastic tumours (author's transl)].

Diagnosis, treatment and follow-up of gestational trophoblastic tumours has become more efficient through the introduction of new methods like angiography, computer tomography and, especially, the determination of specific chorionic gonadotrophin. Exact diagnosis, with differentiation of high- and low-risk patients allows an individual approach to treatment. The results of these new diagnostic and therapeutic methods were studied in a department with a relatively high incidence of gestational trophoblastic disease in a European region, where trophoblastic tumours are generally rare. (Since 1971 16 cases of trophoblastic tumour and 68 patients with hydatidiform mole were treated in the department of Obstetrics and Gynaecology, University of Graz.) Schedules were drawn up for the diagnosis, classification of risk and for treatment. This may help to get good results and to prevent errors in the future. Long-term determination of HCG beta in the serum and also comparative follow-up of LH and HCG in urine led to the formulation of further characteristics of gonadotrophin secretion after hydatidiform mole and treatment of trophoblastic tumours. On the basis of the results a regimen has been formulated which seems to be optimal for the detection of tumour after hydatidiform mole and for the registration of the effect of treatment in case of trophoblastic tumour.

Adult↗
PubMed1979

[Radioimmunoassay of beta sub unit HCG following hydatidiform mole or chorionic carcinoma (author's transl)].

The radioimmunoassay of Beta Sub Unit HCG in the serum heralds a marked improvement in the diagnosis of gestational trophoblastic disease. In nine cases of hydatidiform mole and three cases of chorionic carcinoma serial examinations of the Beta Sub Unit HCG were performed. When the immunologic pregnancy test became negative following a hydatidiform mole or following treatment of chorionic carcinoma, the HCG excretion remained above detectable values for several more weeks. The decrease of Beta Sub Unit serum HCG was either linear or in fluctuations. The detection of fluctuations or a secondary rise in the Beta Sub Unit HCG titre permits the early diagnosis of invasive trophoblastic disease following hydatidiform mole or of insufficient treatment or recurrence in cases of chorionic carcinoma. Our results suggest that the optimal follow-up with Beta Sub Unit serum HCG is by weekly determinations until four consecutive determinations remained negative. This is followed by two determinations at bi-weekly intervals and thereafter monthly follow-up examinations.

Adult↗
PubMed1979

[Amenorrhoea and hyperprolactinaemia (author's transl)].

Prolactin was determined by radioimmunoassay in the serum of 112 patients with primary or secondary amenorrhoea. 21 cases showed hyperprolactinaemia with levels above 25 ng/ml (18.7%). 10 patients with levels between 25 and 50 ng/ml showed heterogeneous clinical features. In nine women (8%) the prolactin level was above 100 ng/ml; they all had severe amenorrhoea. As a result of treatment with bromocriptine menstrual bleeding occurred in 4 out of 7 cases and 2 of these patients became pregnant. In 3 cases prolactin did not return to normal levels and in 2 out of these patients microadenomas of the pituitary gland were diagnosed by special methods. They were removed surgically by the transsphenoidal approach.

Adenoma↗
PubMed1976

[The angiographic diagnosis of trophoblastic tumours (author's transl)].

Pelvic angiograms were performed on ten patients with trophoblastic tumours. Together with a history and HCG determinations the diagnosis can be made with certainty. It is not possible to differentiate between invasive moles and chorion carcinomas. The results of chemotherapy can be clearly evaluated. A normal pelvic angiogram does not exclude a trophoblastic tumour with complete certainty, since this can be localised to other organs. It has the advantage over curettage of being able to show very small tumours, as well as tumours not situated in the uterine cavity.

Adult↗
PubMed1976

[Efficacy of angiography for the diagnosis of trophoblastic tumors (author's transl)].

Angiography has proved valuable as a method for visualizing the position and extent of trophoblastic tumors. Angiography together with the determination of gonadotropin makes a more exact diagnosis possible and, therefore, an individual therapy. The treatment must be intentionally carried out's the age of the patient plays an important role here. For many cases today, purely conservative therapy with cytostatic drugs is possible. This method was used in 11 female patients with suspected or histologically established trophoblastic tumors. In 4 women, the tumor was suspected a because of the reincrease in HCG excretion following a hydatidiform mole. A metastasizing mole was established histologically in 3 patients and a choriocarcinoma, in 4 patients. A good correspondence was found between angiographic and macroscopic findings in 6 women who underwent surgery. In evaluating control angiograms following chemotherapy, it should be noted that tumors do not recede completely in every case.

Adult↗
PubMed1976

[Further reproduction after clomiphene-induced pregnancy (author's transl)].

The study of menstrual pattern and further pregnancy after clomiphene-induced pregnancy showed a comparatively high rate of improved menstrual pattern and of spontaneous conception. 12 of 29 women, who concluded a clomiphene-induced pregnancy more than 2 years ago, showed an improvement of menstrual pattern. Spontaneous conception occurred in 16 of the 29 women, in 2 cases once more. It is remarkable, that 7 of these 16 women conceived spontaneously without any improvement of menstrual pattern following the clomiphene-induced pregnancy. It is therefore difficult, to advise patients and to make a prognosis concerning further fertility. It is not possible to say, that spontaneous conception can be excluded respectively that it will occur. In case of desire for pregnancy another induction of ovulation is indicated, on the contrary contraceptive questions are to be discussed.

Clomiphene↗