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Biomedical subjects

G Touchard

Publications and source records attributed to G Touchard.

At least 91 records · Page 5Linked to original sources
PubMed1985

Association of systemic light-chain deposition disease and amyloidosis: a report of three patients with renal involvement.

Three patients with renal involvement, plasma cell dyscrasia and systemic light chain deposition are reported in whom well characterized amyloid deposits were also found in the vessel walls. This association, not yet reported, is probably more frequent than believed and still brings nearer these two manifestations of monoclonal light chain deposition. Whether or not the finding of amyloid deposits during systemic light chain deposition is a separate entity and modifies the prognosis remains to be answered.

Adult↗
PubMed1985

[Aneurysm of the abdominal aorta, retroperitoneal fibrosis and extramembranous glomerulitis].

The authors report a case of a 58 year old male presenting with bilateral ureteral compression by peri-aneurysmal retroperitoneal fibrosis. A ureterolysis and prosthetic replacement of the abdominal aorta gave good results. Eighteen months postoperatively, proteinuria and an edema of the lower limbs revealed an extramembranous glomerulitis, for which no cause could be found. Was this rare association fortuitous, or does it result from the action of some unknown antigen?

Adrenal Cortex Hormones↗
PubMed1985

[Mature retroperitoneal ganglioneuroma in the adult. A case].

Mature ganglioneuroma, a benign nervous tumor of sympathetic origin, is an uncommon diagnosis in adults, particularly when it is located in the retroperitoneal region. Embryology provides an explanation for detection of this tumor in the adrenal glands. The fortuitous discovery of a lesion of this type in a patient with a homolateral renal adenocarcinoma provoked diagnostic and therapeutic problems that are discussed and analyzed.

Adult↗
PubMed1984

Inverted papilloma of the bladder. A report of 10 cases.

The inverted papilloma is a distinct lesion characterized by its rarity compared to the frequency of the other vesical papillomas. The typical histological aspect of this lesion should lead us to call it adeno-urotheliome. Its progress is generally benign. However, the possibility of recurrence indicates a close periodical cystoscopic follow-up.

Adult↗
PubMed1984

[Massive sarcomatous infiltration of the liver disclosed by jaundice and hepatocellular failure in Waldenström's disease].

We report herein the case of a patient with Waldenström macroglobulinemia in whom an immunoblastic sarcoma produced acute jaundice and hepatic failure. Transvenous liver biopsy, performed because of coagulation deficiencies, revealed massive infiltration of the liver by the sarcoma. Immunofluorescence study showed numerous portal and sinusoidal cells stained exclusively by anti-micron anti-kappa antisera. As shown by others in the literature, this study supports evidence for the same clonal origin of the two proliferations. Chromosomal abnormalities were found in marrow and blood cells (trisomy 5 and 20, 6 q-, 7 q+, and 8 p-); their role in emergence of sarcoma is discussed. This case shows that immunoblastic sarcoma emerging during the course of Waldenström macroglobulinemia may be revealed by severe hepatic manifestations.

Aged↗
PubMed1984

[Pancreatitis: a little-known cause of ureteral obstruction].

Left ureteral stenosis induced by pancreatitis was observed in one case. Five similar cases have been reported in the literature. Ureteral obstructions may be found in two clinical contexts--patent pancreatitis or retroperitoneal fibrosis. The ureter may be simply compressed mechanically, or there may also be enzymatic or ischemic necrosis. The clinical approach should be directed towards treating primarily the pancreatitis and secondarily the urological pathology. As regards the urological treatment, ureterolysis or ilio-ureteroplasty are indicated in cases of organized irreversible ureteral stenosis.

Adult↗
PubMed1984

Cavitation of mesenteric lymph nodes, splenic atrophy, and a flat small intestinal mucosa. Report of six cases.

This study describes, in 6 patients with a flat small intestinal mucosa and splenic atrophy, a particular lesion of the mesenteric lymph nodes termed "cavitation." In 4 women and 2 men with abdominal mass, intestinal obstruction, or suspected celiac disease-associated lymphoma, unusual pseudocystic lymph node lesions were found in the jejunal or jejunoileal mesentery. These lesions consisted histologically of a large central cavity occupied by hyaline-type material and surrounded by fibrous tissue and remnants of lymph node structures. There was no histologic evidence of malignant lymphoma or mesenteric panniculitis. Diffuse subtotal villous atrophy involving at least the jejunum was found in each case, together with unequivocal biological and morphological evidence of splenic atrophy, severe malabsorption, and a history of chronic or childhood diarrhea. HLA B8 or DR3, or both, was present in 4 of 4 cases; dermatitis herpetiformis was present in 1 case. An unequivocal mucosal response to a gluten-free diet was observed in 2 cases. Four patients died of cachexia or hyposplenism-related infections. We conclude that cavitation of mesenteric lymph nodes is an original feature which may be associated with splenic atrophy and a flat small intestinal mucosa; some of these patients may have celiac disease. Pathogenesis is unknown.

Adult↗
PubMed1983

[Vertebral osteonecrosis. Apropos of 4 cases with slow spinal cord compression in 1 case].

The authors report on four cases of aseptic osteonecrosis of the vertebral body in adults (VON). Among these, one patient, in whom histological data were available, presented with a slow spinal cord compression syndrome (SSCCS). This complication is uncommon since only one other similar case has been reported so far (4). VON thus remains an underestimated etiology of SSCCS by non-tumoral compression fracture of the vertebral body. Diagnosis is based on the roentgenograms which evidence osteocondensation with "gaseous dissection" of the vertebral body, the latter being considered as pathognomonic of this disease. The etiopathogeny is still unknown. Treatment is purely symptomatic and the course has always been favorable.

Aged↗
PubMed1983

[Chronic radiation-induced esophagitis after treatment of oropharyngolaryngeal cancer: a little-known anatomo-clinical entity].

Chronic esophagitis induced by radiation therapy (CRE) for carcinoma of the oropharynx and larynx, and involving an initially normal esophagus, is poorly known, and often confused with a locally recurrent malignancy. By reporting 8 consecutive cases, the aim of this study is to contribute to proving that cervical CRE does indeed exist. Eight men, aged 58 to 76 years, developed complete aphagia (7 cases) or severe dysphagia (1 case), 2 to 56 months (median 8.5 months) after radiation therapy for carcinoma of the laryngopharyngeal area. In 5 patients, the primary tumour and/or chains of cervical lymph nodes were removed before radiation therapy; in the 8 patients, the esophagus was endoscopically free of disease. The total dose of radiation exceeded 60 grays in 6 patients. Although they were initially considered as suffering from a locally recurrent malignancy on a clinical basis, none of the 8 patients had patent signs (either endoscopic or histologic) of recurrence. In each case a severe lesion of the cervical esophagus was documented (stenosis 7 cases, giant ulceration 1 case): the diagnosis of CRE was based on endoscopic, histological, and evolutive criteria. Six patients were treated by prolonged nutritional support (via enteral route, 5 cases; parenteral route, 1 case); endoscopic dilatations were used as a single treatment or in association with nutritional support in 4 cases. Three patients died of CRE-induced regional complications; post mortem examination, performed in 2 cases, confirmed CRE without evidence of locally recurrent malignancy.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1983

[A very unusual tumor: inverted papilloma of the bladder].

Based on a personal series of 10 cases seen over a 10 year period, the characteristics of the inversed bladder papilloma are reviewed. Affecting men mainly, and presenting nonspecific signs (hematuria, disorders of micturition or secondary infections), these lesions can be detected by urography and particularly cystoscopy, enabling their extraction by endoscopic resection and histological examination. Histology findings serve to exclude some other tumors or pseudotumors (papillary tumors, urothelial carcinoma, proliferative cystitis). Various histogenic theories are discussed, preference being given to suppression of the term inversed papilloma in favor of adeno-urothelioma. Recurrence after treatment occurred in one case only. One patient had an inversed papilloma associated with a papillary tumor. Typical histology findings and usual benign course enable a good prognosis to be given for these curious tumors.

Adult↗
PubMed1983

[Castleman's pseudotumor. Apropos of a case with pelvic localization].

The authors report a case of a pelvic site of a Castleman pseudo-tumour, still called angio-follicular hyperplasia or lympho-vascular hamartoma. This disorder of unknown aetiology may be situated anywhere along the lymphatic chains (70% of cases in the mediastinum). It is often associated with immuno-haematological disorders. Suitable for surgical treatment, the course is always favourable.

Adult↗
PubMed1983

[Adenomatoid tumor of the tunica vaginalis testis. Apropos of 5 cases].

The authors report five cases of adenomatoid tumour of the tunica vaginalis. Two cases were located on the epididymis and two on the tunica albuginea of the testis. In each case, a limited excision of the tumour without removal of the testis resulted in a cure, confirmed by a follow-up of three years. A histological examination at the time of the operation revealed the exact nature of the lesion in each case, thereby preventing the unnecessary excision of the gonad. The authors then review the literature on the subject with particular mention of the histopathology, the classification of these tumours, the clinical features and the treatment. They stress that in the majority of cases, mesotheliomas of the tunica vaginalis are benign and can be treated with limited excision and conservation of the testis. However, a few malignant forms have been described, hence the need for a careful histological examination.

Adult↗