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G Tonini

Publications and source records attributed to G Tonini.

134 records · Page 8Linked to original sources
PubMedDate not supplied

[Cerebellar metastasis from pancreatic adenocarcinoma: report of a clinical case].

We describe a case of a metacronous cerebellar metastasis from pancreatic adenocarcinoma occurred in a 67 years old male. Central nervous system metastases from pancreatic carcinoma are mostly autoptic findings. To our knowledge, this is the first case reported in literature of cerebellar metastasis from pancreatic cancer; furthermore, this case calls attention on vomit presentation that could be erroneously attributed to an abdominal relapse. Due to the increasing frequency of central nervous system metastases observed in recent years in other types of cancer, some authors speculate that this event could represent a consequence of the prolonged natural history as the result of improved survival.

Adenocarcinoma↗
PubMedDate not supplied

Paraneoplastic syndromes: what we know and what we should know.

Paraneoplastic syndromes are a group of clinical disorders associated with malignant diseases that are not directly related to the physical effects of primary or metastatic tumor. Those that are associated with the secretion of circulating peptides may be used as a useful tool in monitoring patients after the start of chemotherapy. Most of the paraneoplastic syndromes represent an interesting tool of internal medicine. Moreover, they also represent a starting point for a work up in patients with an occult neoplasia, even though the clinical presentation may be very multifaceted. As consequence of all these considerations, the present editorial represents a useful tool for a rational approach to paraneoplastic syndromes.

Humans↗
PubMedDate not supplied

[Changes in the immunologic profile of newly-diagnosed diabetic patients during the first year of the disease].

Immunological markers including ICA-IgG, CF-ICA, other non organ specific autoantibodies, circulating immune complexes (CIC), IgG, IgA, IgM, C3, C4 and lymphocyte subpopulations (OKT3, OKT4, OKT8) were studied at onset in 32 insulin dependent diabetic patients (16 males, 16 females, aged 1-21 yr.). Other non organ specific autoantibodies, CIC, IgG, IgA, IgM, C3, C4 and OKT3, OKT4, OKT8 were also studied after a 6-12 months follow-up in the same group of patients. ICA-IgG and CF-ICA were also studied in a control group of 19 insulin dependent diabetic patients with an over 3 year history of diabetes. ICA IgC, CF-ICA, other autoantibodies and CIC were detected at diagnosis in 65%, 19%, 33%, and 50% of patients respectively. ICA-IgG and FC-ICA were detected respectively in 15% and zero of the control group of 19 long standing diabetes. No alterations in IgG, C3 and C4 levels and in T cells subsets have been found at onset. C4 levels significantly decreased at the successive observation. A significant elevation of IgG levels and helper/suppressor ratio were also observed at follow-up. Autoantibodies and CIC positive sera at diagnosis support the concept that a previous autoimmune disorder exists before clinical manifestations of diabetes. Other immunological abnormalities including relative hypogammaglobulinemie, lower C4 and higher helper/suppressor ratio, observed by other authors (Kanakoudi 1984, Vergani 1985, Lernmark 1985) represent an aspecific alteration due to metabolic imbalance or to an earlier immunological disorder.

Adolescent↗
PubMedDate not supplied

[Insulin-dependent diabetes mellitus. Study and follow-up of 100 cases].

UNLABELLED: Clinical records of one hundred pediatric patients affected by IDDM have been analyzed. All the patients have been followed since the beginning of the disease and they have had a check up on average of four months (weight, height, blood pressure, HbA1, C peptide, Triglyceridemia, renal function were evaluated). The method of home-self-monitoring was applied. After four years, and periodically thereafter, microvascular abnormalities were evaluated in all the patients by fluorescein angiography. Neuropathy was evaluated only in symptomatic patients by peripheral nerve conduction. The average follow up period was 6.1 years (range 1-20). RESULTS: the onset of the disease was expressed in 11% of the cases by coma, in 14% by ketoacidosis, in the remaining cases by hyperglycemia only. The severity of initial symptoms has progressively and significantly decreased in the last years. In 7% of the subjects diabetes affected more members of the same family (4 couples of siblings and 3 couples of parent-child). An infection preceding the onset of the disease was present in the history of 23% of the cases. Islet cell antibodies were found in 83% of the studied cases at the onset of the disease. In 80 out of the 100 patients a detailed history has been obtained about the occurrence of ketoacidosis episodes after the first admission and about the occurrence of severe hypoglycemic crises (seizures and/or coma). 17% of the patients presented at least one ketoacidosis episode after the first admission (the main cause was infection before 12 years of age, an emotional problem thereafter).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Atheromatosis and double media: uncommon vascular lesions of renal allografts.

Study of 45 renal allograft nephrectomy specimens revealed the presence of relatively uncommon arterial vascular lesions: atheromatosis (12 cases) and a double layer of smooth muscle in the intima (Double Media) (4 cases). Histopathologic features of atheromatosis showed the presence of large lipid-laden cells localized in the intimal layer of arteries. Diagnosis of acute vascular rejection (AVR) was made in 19 cases. Diagnosis of chronic vascular rejection (CVR) was found in 4 cases. 22 cases showed lesions of both AVR and CVR. In 12 cases there was infiltration of the intima and media wall by foam cells closely resembling an atheromatous lesion. Four cases of Double Media were found in allografts with survival varying from 51 to 344 days. The presence of either atheromatous or double media does not correlate statistically with immunosuppressive treatment, blood pressure or with the presence of hypertriglyceridemia and/or hypercholesterolemia. Immunohistochemical investigation of atheromatosis revealed total negativity of the foam cells with antisera to: actin, myosin, desmin and myoglobin. Variable reactivity was observed with antisera to vimentin. Myointimal cells of Double Media expressed slight positivity for actin and vimentin. The double media lesion seems to be the result of a reparative vascular process secondary to rejection changes. Atheromatosis seems to be closely correlated to episodes of acute rejection. Vascular lesions in grafts are harbinger of poor prognosis. Double media lesion and atheromatosis do not seem to have a more unfavourable prognostic significance on the evolution of the transplants.

Acute Disease↗