Biomedical subjects
G Timm
Publications and source records attributed to G Timm.
Decreased N-acetyl-aspartate/choline ratio and increased lactate in the frontal lobe of patients with Huntington's disease: a proton magnetic resonance spectroscopy study.
BACKGROUND: Both the effect of the mutation and the pathogenesis of Huntington's disease are unknown and a lack of biological markers for the natural history of the disease impedes the evaluation of novel therapeutic approaches. METHODS: Proton magnetic resonance spectroscopy was carried out on a frontal region of the cortex in 17 patients with clinically overt Huntington's disease and four asymptomatic gene carriers. RESULTS: Eight of 17 (47%) clinically affected patients with Huntington's disease and each of the asymptomatic carriers had lactate peaks in the frontal cortex which were not present in controls. The N-acetyl-aspartate/choline (NAA/Ch) ratio was significantly reduced in the symptomatic patients indicating the presence of neuronal loss. The reduction was related to the clinical severity of the disease and was absent in the asymptomatic carriers. CONCLUSION: The finding of lactate peaks supports the hypothesis that disturbed cerebral energy metabolism contributes to the pathogenesis of Huntington's disease.
[Proton magnetic resonance spectroscopy in transient disorders of the cerebral circulation].
Proton magnetic resonance spectroscopy of the brain was performed in 8 patients with asymptomatic carotid stenosis as well as in 26 patients with transient ischemic attacks (TIA) and 19 patients with reversible ischemic neurologic deficiency (RIND). The study was carried out by means of Philips apparatus. The results of investigation were compared with data of spectroscopic examination of 9 older and 10 younger normals. The mathematical analysis of ratio of N-acetylaspartate concentration (NAA) to phosphocholine (Pch), phosphocreatine (Pcr), and lactic acid was used to describe the metabolic changes. As a result lactic acid was not found in control volunteers' brains while it was detected either in the damaged (59%) or in the contralateral (47%) hemispheres of the patients. The significant decrease of NAA/Pch and NAA/Pcr ratios was observed in the pathological hemispheres of the patients. These results testify to high sensitivity of proton magnetic resonance spectroscopy for evaluation of metabolic disturbances in latent or reversible cerebral ischemia.
[Spermatozoal antibodies in cervical mucus and in the luminal fluid of the uterus in sterile patients].
Poor postcoital tests in infertile patients may be due to dysmucurrhoea, low sperm count, or specific antibodies against spermatozoa. Using a latex agglutination test ("Sperm-antibody-slide-test", Fa. Biotec, Hannover), we examined the cervical and uterine secretions of the patients for sperm antibodies. The results showed a close correlation between a positive sperm-antibody-test and a poor postcoital test, especially in those couples with regular sperm quality. Also in cases with normal postcoital tests, positive sperm-antibody titers can be observed. Therefore, the sperm-antibodies may disturb fertilization in infertile patients even without causing immobilization or agglutination of the spermatozoa in the female genital tract fluids. The determination of the spermatozoa-antibody content in the cervical and uterine secretions must be regarded as an improvement in the diagnostic procedure in human infertility.
[Nuclear magnetic resonance spectroscopy in medicine].
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[The clinical picture of retinopathia oxalogenica (author's transl)].
A presentation is given of the severe changes in the retina of a 26-year-old man caused by intraocular Calciumoxalate crystals with clinical, histological and polarizing optical findings. The stadia of the retinopathia oxalogenica are classified here.
[Incidence of bulbus enucleation following perforating eye injuries in relation to age].
The detailed consideration of enucleated eyes after traumatic perforations--material of a period of 20 years--shows some of age related facts. The largest part of enucleations comes from the age of 15 to 30, though the prognosis of preservation of the eye is favourable in this group of age. The rate of enucleations of the examinated material ascends with the age in males. Females have in the age of 46-60 years the highest rate of enucleations.
[Glomus tumors of the eyelids (author's transl)].
Two new observations of glomus tumors in the eyelid are reported, one of the angiomatous type, the other of the more adenoid type. The typical symptoms of other than ophthalmological localisations are described. The clinical diagnosis is possible. In the few cases reported by ophthalmologists the diagnosis is made by the histologist.
A prosthetic sphincter for the gastrointestinal tract.
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[Experimental insulin allergy and diabetic glomerulosclerosis (author's transl)].
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Sensory innervation of the mammalian urethra.
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[Uvea findings in multiple myeloma].
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[Senile hyperplasia of the ciliary epithelium].
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[Uveal involvement in leukemias, reticuloses and related diseases].
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[Special cases in the intraocular tumor diagnosis. Clinical aspects of primary intraocular manifestations of extraocular tumors and clinical diagnostic errors of secondary intraocular tumors].
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[Age dependency of uveitis].
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[Incidence of calcium deposits in the uvea].
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