High blood pressure in men aged 50--a population study of men born in 1913.
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Biomedical subjects
Publications and source records attributed to G Tibblin.
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Signs in the fundus oculi, long regarded as prognostic in hypertensive disease, have been shown to be subject to gross observer error and bias when assessed in conventional ways. The authors describe unconventional ways of assessing diminution of vascularity in a population sample of men aged 50 and also in a group of hospital patients.They show that a method simple enough to be learnt by a schoolboy in 20 minutes gives information that is more precise and less biased than data obtained by more conventional means. Standards can be prepared and the information is quantitative.The unconventional data are closely related to the level of hypertension. Some anomalies in the data, possible ways of improving them and ways of testing their relation to prognosis are discussed.
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In 1980 we examined 707 67-year-old men, 656 of whom had no previous myocardial infarction. During 8 years of follow-up, 70 (10.7%) of the 656 men developed a first myocardial infarction or died from coronary heart disease (CHD). The incidence of CHD increased 1.6-fold from the lowest to the highest quintile of cholesterol levels, 2.7-fold from the lowest to the highest quintile of triglyceride levels, and 2.2-fold among those with diabetes. Blood pressure, smoking habits, and two measurements of obesity (body mass index and waist circumference) were not significantly related to the incidence of CHD. In multivariate analysis, serum triglyceride levels and blood glucose concentration remained as significant risk factors for CHD. This may reflect that disturbances in glucose and triglyceride metabolism (as part of a metabolic syndrome?) are more important CHD risk factors in older than in younger men.
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A study of 1371 men 20, 30, 50 and 60 years old and living in Göteborg was performed to obtain information on the incidence and prevalence of otitis media in a non-selected population. In addition to anamnestical data, a thorough examination of the ENT-status was made by one observer. There was no indication that otitis media has become a more rare disease since the early part of the century. However, the course of the disease does seem to be shorter and milder in more recent decades. This conclusion is supported by a substantially higher frequency of grave pathologic changes in the tympanic membranes in the two oldest cohorts compared with the two younger. A further indication is that mastoidectomies have become a rare type of operation during recent decades.
A study of 1371 men 20, 30, 50 and 60 years old and living in the city of Göteborg was performed to obtain information on otitis media infections in the general population. In addition to anamnestic data, a thorough examination of the ENT status was made by one observer. In this second report a sizable proportion of the men reported a history of otitis or otorrhea but had normal tympanic membranes. However, overall there was a close correlation between a positive history of otitis and otorrhea, and findings of pathological tympanic membranes in all the age groups, and the longer the duration of the otitis with or without otorrhea, the more frequent were the pathological findings. Men with a history of both otitis and otorrhea of long duration had generally more serious pathological findings than men with otitis but no longterm otorrhea.
Within the framework of the Study of Men Born in 1913 and 1923, which is a prospective population study in Gothenburg, Sweden, a subsample consisting of 128 men 20, 30, 50, and 60 years old was investigated in order to elicit information on factors influencing the size of the mastoid cell systems, measured planimetrically from X-ray films. The mastoid cell area (MCA) closely correlated with body size, height being the best measure. Young men had larger relative MCAs (adjusted for height) than old men. Within each age group, men with small relative MCA were characterized by a lower social class, a longer history of otitis media, more tympanic membrane pathology, and more hearing loss than men with large MCA. These results support the view that in addition to genetic factors, environmental factors may exert a strong influence on the development and ultimate size of the mastoid cell systems.