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G Thurston

Publications and source records attributed to G Thurston.

5 recordsLinked to original sources
PubMed1991

Computer automation in measurement and analysis of cell motility in vitro.

The application of computerized techniques to the study of cell motility has allowed direct examination and quantitation of individual cell movement and morphology. This has stimulated interest in theoretical models of cell motility, and has prompted the need for increasingly sophisticated approaches to analyze and present cell motility data. In this article we review some of the microscope systems currently used to study cell motility, and give more details on such a system developed in our own laboratory, the DMIPS Cell Analyzer. Brief examples of its application to the field of cell motility are provided. Some areas of further research in the field of automated microscopy are also discussed.

Animals↗
PubMed1991

Anticoagulant treatment does not affect the action of flavone acetic acid in tumour-bearing mice.

Flavone acetic acid (FAA) is a novel antitumour agent that has a profound effect on the vasculature in murine tumour models. Previously we have shown that FAA induces a coagulopathy and thrombocytopaenia in tumour-bearing mice, and the purpose of the present study was to determine the significance of the FAA-induced intravascular coagulation in the antitumour action of FAA. Several anticoagulant agents were tested for their effectiveness in altering ex vivo coagulation of murine plasma; heparin and ancrod were found to be most effective. These agents were administered to tumour-bearing mice prior to FAA and TNF treatment with little effect on the induced regrowth delay. However: the FAA-induced consumption of platelets in tumour-bearing mice was not blocked by anticoagulant treatment. These data suggest that platelet consumption occurs independently of the normal coagulation pathway, and further that fibrin deposition may not be a major factor in the antitumour action of FAA.

Adenocarcinoma↗
PubMed1976

"Friends".

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Female↗