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Biomedical subjects

G Thiene

Publications and source records attributed to G Thiene.

At least 361 records · Page 20Linked to original sources
PubMed1979

[Anatomy of papilla and intra-renal reflux: microradiographic and histologic investigations (author's transl)].

After a group of autoptic kidneys, taken from new-born babies, had been injected via the ureter with micronised barium at various pressures, they were examined micro-radiographically and histologically in order to observe the appearance of intra-renal reflux and the anatomical structures involved. The radiological patterns, clinically observed during cysto-uretrography, were also considered. The intra-renal reflux is tubular, when injection is carried out at a low pressure, whereas at higher pressures one can observe the erosion of the fornices of the calyces and the following sino-lymphatic and/or venous drainage.

Histological Techniques↗
PubMed1979

Complete atrioventricular canal associated with conotruncal malformations: anatomical observations in 13 specimens.

Conotruncal anomalies associated with atrioventricular (AV) canal defects are more common than is generally appreciated on clinical grounds. Among 39 specimens of AV canal malformations, 13 (33%) presented with conotruncal abnormalities: a complete form of AV canal has been observed in all. 5 cases exhibited visceral situs solitus, 5 situs ambiguus with asplenia and 3 situs ambiguus with polysplenia. In the first group, conotruncal anomalies were tetralogy of Fallot in 3 cases, bilateral conus with double outlet right ventricle (DORV) in 2, one with subpulmonary ventricular septal defect (VSD) and the other with doubly commited VSD. Survival in these patients was relatively longer (average 20 mth) and the clinical course was mainly determined by the degree of the pulmonary outflow obstruction: surgical correction should have been feasible in these cases. Patients with situs ambiguus, both with asplenia and polysplenia, had further severe cardiovascular malformations associated with AV canal which led to early death (average survival 12 days): anomalous pulmonary and systemic venous return and univentricular hearts. In the latter patients, tetralogy of Fallot, bilateral conus with DORV and pulmonary atresia were the conotruncal malformation. Retrospectively, in no case of the last category a complete repair had been accomplished. All but one specimen presented the complete form of AV canal with 'free floating anterior leaflet' and hypoplastic anterior tricuspid component. This hypoplasia could be interpreted as missing conal tissue in the development of the anterior tricuspid cusp. For this leaflet a dual embryological origin, both from the dextro-dorsal conal ridge and the right lateral AV cushion, is suggested.

Abnormalities, Multiple↗
PubMed1979

[Transposition of the great arteries: anatomic types of left ventricular outflow tract obstruction (author's transl)].

A postmortem investigation has been carried out in 48 heart specimens with transposition of the great arteries (TGA) to evaluate incidence and type of left ventricular outflow tract obstruction. The frequence of pulmonary stenosis in our series (23%) is similar to those reported from previous studies. Cases have been divided in two groups according to presence or absence of ventricular septal defect. In cases with intact ventricular septum the obstruction was determined by asymmetric hypertrophy of the septum (1 observation) and by abnormal attachement of clefted anterior mitral leaflet to the interventricular septum (2 observations). In the specimens with ventricular septal defect, 4 presented a stenosis due to malalignment of the infundibular septum, associated with valvular stenosis in 1 case and with valvular stenosis and fibrous subvalvular ring in 2. Another case presented a stenotic pulmonary valve and a parachute mitral valve. The remaining 3 showed a cleft of the anterior leaflet of the mitral valve. The high incidence of infundibular malalignment obstruction is underlined together with its association with A-P or L-position of the aorta. This peculiar relation of the great arteries could be angiocardiographically employed as indicative for the presence of this type of left outflow tract obstruction in TGA.

Female↗
PubMed1979

[Left atrial myxoma revealed by saddle occlusion of the aortic carrefour (author's transl)].

A case of a left atrial myxoma revealed a saddle occlusion of aortic carrefour is reported. The embolus has been surgically removed and histology allowed to recognise its myxomatous nature, suggesting source for left atrial cavity. Cardiac catheterisation and angiocardiography confirmed the presence of atrial tumor, which has been successfully excised. Embolisation is referred to villous, friable surface of the neoplasm. Employment of echocardiography in patients with arterial emboli from unknown etiology is highly recommended.

Adult↗
PubMed1979

[Atrial myxoma. Clinical, diagnostic, surgical and pathological features of 13 subjects (author's transl)].

The clinical, surgical and pathological features of 13 patients (3 males, 10 females) with cardiac myxoma are reported. Eleven masses were situated in the left atrium and 2 in the right one. The incidence of signs and symptoms usually ascribed to cardiac myxoma is evaluated. Particular emphasis is given to embolization phenomenon which occurred in 3 patients with villous-surfaced tumors. The results of phonocardiographic, echocardiographic and isotopic angioscintigraphic examination are illustrated and the use of these incruent investigations is highly recommanded. Final diagnosis may be achieved by cardiac catheterization and angiocardiography. Successful surgical excision was carried out in 12 patients. Structural profile of atrial myxoma is discussed. Particular attention is given to the surface of the tumors (smooth or villous), to the pseudovascular structures on the light microscopy and to the endotelial like features, together with secretory activity of the myxoma cells, on the electron microscopy. The morphologic findings support the neoplastic origin of the myxoma. The distinction between embolization and malignant metastasis is underlined.

Adult↗
PubMed1978

Androgen producing adrenocortical carcinoma.

Two cases of androgen secreting adrenocortical carcinoma have been described by light and electron microscopy. The histological and ultrastructural features of the tumour cells were similar to those of compact cells of zona reticularis and to those described in virilizing adenomas. They possess numerous mitochondria with lamellar and tubular cristae, abundant smooth endoplasmic reticulum, lipofuscin bodies and scanty lipid. Irregularly shaped, crenated mitochondria, with outpouchings of the outer limiting membrane have also been observed. The clusters of neoplastic cells were surrounded by basement membrane which demonstrated a focal discontinuity, probably reflecting malignancy of the tumours. Hyperplasia of smooth endoplasmic reticulum and the presence of outpouchings of the mitochondrial outer limiting membrane might be the morphological manifestation of endocrine activity of the tumours.

17-Ketosteroids↗
PubMed1978

Involvement of the cardiac conducting system in panarteritis nodosa.

Histopathological observations on the conduction system of the heart were carried out in three cases of panarteritis nodosa. This specialized tissue was involved in each case secondary to ischemia and/or periarterial extension of the inflammatory process affecting the nutrient arteries of the conducting system. The high risk of disturbances in impulse formation and conduction in patients with panarteritis is emphasized as well as the need for appropriate clinical investigation (protracted cardiac monitoring and control by catheter recording and stimulation) in order to secure early detection and prevention of life-threatening arrhythmias.

Adult↗
PubMed1978

The natural history of hypertension in turkeys.

1. Variables involved in the genesis of hypertension in male broad-breasted white turkeys include social environment, obesity and high salt intake. 2. The hypertension is characterized by low plasma renin activity and, with increasing age, normal to high plasma aldosterone. 3. Medionecrosis of the abdominal aorta is a common pathological finding. 4. The absence of atherosclerotic plaques is probably related to the high concentrations of alpha-lipoproteins.

Aging↗
PubMed1978

A case of surgically corrected Wolff-Parkinson-White syndrome. Clinical and histological data.

A case of type B Wolff-Parkinson-White syndrome, with intractable atrial fibrillation, underwent surgical division of a right-sided accessory atrioventricular bundle of Kent. Pre-excitation and complicating tachyarrhythmias were henceforth abolished for 6 weeks, when the patient died of infective endocarditis. Histological examination showed a divided Kent's accessory atrioventricular pathway and apparently functionless James and Mahaim fibres.

Atrial Fibrillation↗
PubMed1978

Systemic-pulmonary arterial supply in pulmonary atresia with ventricular septal defect: postmortem angiograms and histologic survey.

Postmortem angiographic and histologic studies of the pulmonary arterial circulation were performed in a patient with pulmonary atresia and a ventricular septal defect. While the left lung was supplied by a closing ductus arteriosus, the right lung was supplied by two systemic pulmonary arteries arising from the descending aorta. The examination disclosed that systemic pulmonary arteries lead into the pulmonary vascular bed and the capillaries of the alveolar walls. According to these observations, such collateral circulation is to be considered functional. The pulmonary vascular bed, supplied by the ductus arteriosus and the stenotic systemic pulmonary artery, showed a thin muscular layer in the small arteries and arterioles. On the contrary, medial hypertrophy and severe intimal proliferation were observed in the pulmonary segments perfused by the other large unobstructed systemic pulmonary artery, thus proving that asymmetric pulmonary vascular disease may complicate the natural history of this malformation.

Collateral Circulation↗
PubMed1978

[Idiopathic congestive cardiomyopathy. Absence of histopatological for adrenergic hyperactivity (author's transl)].

Extensive histopathological investigation of hearts from patients with idiopathic congestive cardiomyopathy failed to reveal "myofibrillar degeneration", a lesion ascribed specifically to cathecolamine cardiac overstimulation. Morphological support of the theory of adrenergic hyperactivity in the development and progression of this disease is not provided by the present study.

Adolescent↗
PubMed1978

[Sudden death].

Explore the source record for details and available documents.

Adult↗
PubMed1978

[Clinical and angiographic observations in aneurysm of the membranous septum. Pathologenetic implications].

Aneurysm-like kialations of the membranous septum are described with increasing frequency in association to a ventricular septal defect (VSD). Their etiology may be congenital, though with different pathogenesis and acquired. An anatomical distinction between true aneurysm of the membranous septum and pseudoaneurysm is proposed. The acquired forms may be joined to a decrease of left to right shunt and are regarded as the mechanism of closure of a VSD. Nine cases of aneurysm-like dilation of the membranous septum are presented: an interpretation of their etiology and pathogenesis is discussed, on the basis of the history and clinical and instrumental data.

Adolescent↗