Biomedical subjects
Publications and source records attributed to G Tell.
A sensitive radioreceptorassay for human and animal gonadotropins made it possible to demonstrate and quantitate a Rat chorionic gonadotropin (rCG) in placental extracts and amniotic fluid. rCG appears as soon as day 8 and concentration is maximum at day 13 of gestation. This hormone might be the major ovarian stimulatory factor during mid gestation period.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
PURPOSE: To evaluate the prognostic value of the DNA repair/redox-protein Ape1/ref-1 in a retrospective series of consecutive non-small cell lung carcinomas (NSCLC). PATIENTS AND METHODS: Sections from 91 radically resected NSCLC were analyzed for immunohistochemical expression of Ape1/ref-1. For each case 1,000 tumor cells were evaluated to detect nuclear and cytoplasmic reactivity scored as a percentage of positive cells. With respect to sub-cellular localization and percentage of immunoreactive cells, each tumor was classified as "cytoplasmic" or "non cytoplasmic". The survival rate according to Ape1/ref-1 sub-cellular localization was calculated. RESULTS: The main pattern of Ape1/ref-1 expression was nuclear. No significant difference was observed in Ape1/ref-1 pattern according to histotype (squamous vs adenocarcinoma). Among adenocarcinomas, a cytoplasmic expression of Ape1/ref-1 was significantly associated with poor survival rate in univariate (p=0.01) and multivariate (p=0.07) analyses. In addition, a cytoplasmic expression of the DNA repair protein was also predictive of worse prognosis (log-rank test, p=0.02) in cases with lymph node involvement, regardless of histotype. CONCLUSION: The results suggest a potential role of Ape1/ref-1 sub-cellular localization as a prognostic indicator in patients with NSCLC. In particular, cytoplasmic localization of the protein seems to confer a poor outcome in subgroups of patients with nodal involvement or adenocarcinoma histotype.
The case of a 12 year-old European girl who lived in Senegal for 9 months and who presented with Western-African trypanosomiasis is reported. The diagnosis was made because of the occurrence of uveomeningitis following progressive alteration of her general condition. A favorable outcome was observed after two intravenous courses of Eflornithine (difluoromethylornithine, DFMO).
Explore the source record for details and available documents.
Explore the source record for details and available documents.