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Biomedical subjects

G Telegdy

Publications and source records attributed to G Telegdy.

At least 271 records · Page 15Linked to original sources
PubMed1975

Effect of adrenocortical hormones on activity of the serotoninergic system in limbic structures in rats.

A single dose of corticosterone (1 mg/kg b.w.i.p.) increased the 5-hydroxytryptamine (5-HT) content in the mesencephalon, amygdala and hypothalamus. The maximum was observed at 15 min following administration. The 5-HT level returned to normal between 60 and 180 min. The 5-hydroxyindoleacetic acid (5-HIAA) content decreased in the mesencephalon and hypothalamus at 15 min, and then increased to the maximum at 30 min in the mesencephalon and at 45 min in the hypothalamus and amygdala. There were no changes in the septum and hippocampus either in 5-HT or in 5-HIAA content following corticosterone administration. Desoxycorticosterone administration (1 mg/rat i.p.) was ineffective. Tritiated 5-HT uptake did not change in the hypothalamus and mesencephalon tissue in vitro after corticosterone or desoxycorticosterone treatment. Adrenalectomy caused a decrease in the 5-HT content in all brain areas studies. 5-HIAA decreased only in the hypothalamus. Corticosterone administration normalized the 5-HT and 5-HIAA content in the hypothalamus and mesencephalon in adrenalectomized rats. Tritiated 5-HT uptake was lower in the hypothalamus and mesencephalon in adrenalectomized rats. Corticosterone administration increased the activity back to normal in the hypothalamus, however desoxycorticosterone was ineffective. The data suggest that the plasma corticosterone level plays a role in the regulation of the activity of the serotoninergic system in certain limbic brain structures.

Adrenal Glands↗
PubMed1975

Dose-related dual action of corticosterone on hypothalamic serotonin content in rats.

The effect of corticosterone administered in different doses has been studied on hypothalamic serotonin (5-HT) content. A single intraperitoneal injection of the hormone in doses of 1.0 and 2.0 mg/kg bw. increased the serotonin content of the hypothalamus at 30 min after administration. Five mg/kg had no effect, while 10.0 mg/kg decreased the serotonin content. The data provide an explanation for the controversial findings of different authors having used different doses of different glucocorticoids and on the basis of the results it is emphasized that the action of glucocorticoids on hypothalamic 5-HT content is a dose-dependent dual effect.

Animals↗
PubMed1975

The effect of oestrogen and progesterone on maternal behaviour in rats.

Treatment or implantation of oestrone, oestradiol or progesterone on the third day postpartum into the ventromedial-arcuate region of the hypothalamus produced a complex pattern of changes in established maternal behaviour in rats. Progesterone implanted into the ventromedial-arcuate region of the hypothalamus increased the time spent nursing. In contrast, it was shortened by oestradiol given subcutaneously or implanted hypothalamically or extrahypothalamically, or by oestrone implanted into the hypothalamus. Oestradiol by an route used oestrone implanted into the hypothalamus caused marked reduction of pup weight and retrieval frequency. Progesterone had no such effect. Maternal care involving retrieval, sniffing, licking and nursing, expressed in seconds care, declined after hypothalamic and systemic oestradiol treatment. However, oestrone implanted into the hypothalamus increased seconds of care on days 9 and 10. Progesterone did not affect this function.

Amygdala↗
PubMed1975

Site of action of 5-hydroxytryptophan and 5-hydroxytryptamine on the hypothalamo-pituitary-adrenal system in vitro.

5-hydroxytryptamine at a concentration of 0.04 microgram/ml was able to block the ACTH release caused by hypothalamic tissue (CRF) while it was ineffective when a hypothalamic extract containing CRF was used. 5-hydroxytryptophan added to rat adrenal tissue caused a dose-dependent increase in corticosterone production. In a dose of 0.04 microgram/ml, 0.4 microgram/ml and 4.0 microgram/ml, 5-hydroxytryptophan was able to inhibit the ACTH release caused by hypothalamic tissue in vitro. However 0.04 microgram/ml was ineffective on the increase in ACTH secretion elicited by hypothalamic extract CRF. The data suggest that the inhibitory action of 5-hydroxytryptophan and 5-hydroxytryptamine is exerted at the hypothalamic level by inhibiting the release and/or synthesis of the corticotrophic releasing factor.

5-Hydroxytryptophan↗