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Biomedical subjects

G Teasdale

Publications and source records attributed to G Teasdale.

At least 19 recordsLinked to original sources
PubMed1979

Effects of apomorphine upon local cerebral blood flow.

The effects of apomorphine (0.1 mg/kg) upon local cerebral blood flow were examined in anaesthetized baboons. Proportionately similar increases in local cerebral blood flow were observed following apomorphine in the caudate nucleus (40%), cerebral cortex (38%) and cerebellar cortex (26%), despite the marked differences in the density of the dopaminergic innervation to these structures.

Animals↗
PubMed1979

Prognosis of patients with severe head injury.

The relationship between clinical features of brain dysfunction in the first week after severe head injury and outcome 6 months later has been analyzed for 1000 patients. Depth of coma, pupil reaction, eye movements, and motor response pattern, and patient age prove to be the most reliable predictors. The degree of brain dysfunction changes markedly soon after injury, and more reliable predictions of outcome result when assessment is based on the best level of functioning recorded in each early epoch. Predictions based on very early assessment are, therefore, often unduly pessimistic. Individual predictions of outcome, based on a large data bank, provide a powerful tool for assessing the relative efficacy of alternative treatments.

Adolescent↗
PubMed1979

Long-term neuropsychological outcome of closed head injury.

Long-term recovery from severe closed head injury was investigated in predominantly young adults whose Glasgow Coma score was 8 or less at the time of admission. Of the 27 patients studied (median follow-up interval of 1 year), 10 attained a good recovery, 12 were moderately disabled, and five were severely disabled. In contrast to previous studies suggesting that intellectual ability after severe closed head injury eventually recovers to a normal level, our findings showed that residual intellectual level, memory storage and retrieval, linguistic deficit, and personal social adjustment corresponded to overall outcome. All severely disabled patients and several moderately disabled patients exhibited unequivocal cognitive and emotional sequelae after long follow-up intervals. Analysis of persistent neuropsychological deficit in relation to neurological indices of acute injury severity demonstrated the prognostic significance of oculovestibular deficit.

Adolescent↗
PubMed1979

Monitoring of cortical excitability during induced hypotension in aneurysm operations.

The electrical excitability of the cortex was monitored during craniotomy in 10 patients with ruptured aneurysms, to test their ability to tolerate hypotensive anesthesia. Excitability was assessed by measuring the direct cortical response, a response evoked and recorded from the surface of the brain. Previous animal experiments had shown that this response can be used as an index of cerebral blood flow. In the 10 patients the response progressively declined as the blood pressure was lowered and increased when the pressure was restored. Observation of the direct cortical response during aneurysm operations is a practical method for evaluating the electrophysiological responsiveness of the cortex during hypotension, and the authors suggest that decreases in the amplitude of the response are related to decreased in local cerebral blood flow.

Adult↗
PubMed1978

Observer variability in assessing impaired consciousness and coma.

Head-injured patients were examined by a number of observers whose assessments were compared. Considerable discrepancies occurred when overall "levels" of consciousness and coma were used, and also with some terms which are in common use. More consistent assessments were obtained by employing the "Glasgow Coma Scale," which describes eye opening, verbal behaviour, and motor responsiveness. Nurses and general surgeons were as consistent as neurosurgeons when using this scale, and it was relatively resistant to language or cultural differences between observers. The practical reliability of the Glasgow scale enhances its value, both for monitoring individual cases and for making meaningful comparisons between series of patients with acute brain damage.

Attitude of Health Personnel↗