189 clinical and serological examinations were performed in 30 patients before treatment and during follow up of squamous cell cervical cancer stage FIGO III. The serum levels of the tumor markers squamous cell carcinoma antigen (SCC), tumor associated trypsin inhibitor (TATI) and tissue polypeptide specific antigen (TPS) were determined. Sensitivity/specificity for SCC was 63%/91%, TATI 54%/74%, TPS 59%/86% and for a combination of SCC and TPS 81%/77%. In 14 women with recurrence of disease SCC showed lead time effects in seven patients in a time range from three to nine months. SCC was pre-therapeutically elevated in nine cases and showed lead time in five of them. Pretherapeutic TPS serum levels were elevated in seven cases. In all of them lead time effects appeared ranging from three to nine months. TPS never showed lead time effects in patients without elevated pretherapeutic levels. A combination of SCC and TPS in our material provided lead time in 10 of 14 cases.

Adult↗

PubMedDate not supplied

[Determination of alpha 2-macroglobulin and alpha 1-antitrypsin in amniotic fluid using laser nephelometry].

By using Laser nephelometry concentration of alpha 2-macroglobulin and alpha 1-antitrypsin in amniotic fluid was measured in early pregnancy (15th-24th week) and near term (after 37th week). alpha 2-macroglobulin was demonstrable in all cases, concentration of specimen after 37th week were significantly higher than in early pregnancy. Concentration of alpha 1-antitrypsin changes during pregnancy similar to total protein and albumin concentrations.

Amniocentesis↗

PubMedDate not supplied

[Behavior of the fibronectin content of the amniotic fluid].

Concentration of fibronectin in amniotic fluid was compared in early pregnancy and after 35th week of gestation. Content of amniotic fluid fibronectin between 15th and 20th week was significantly higher than after 35th week. Fibronectin-level was higher in amniotic fluid of female fetuses (15th-20th week) whereas concentration of protein in amniotic fluid of cases with chromosomal anomalies was declined (15th-21st week demonstrable.

Amniocentesis↗

PubMedDate not supplied

[Histidine-rich-3,8S-alpha 2-glycoprotein in normal pregnancy and EPH-gestosis].

Histidine-rich-3,8S-alpha 2-glycoprotein (HRG) was determined in samples of plasma collected during normal pregnancy after 15th week. HRG-level declines during pregnancy to about half concentration of start of second trimester. HRG-level return by 9 days post partum to level of nonpregnant women. In cases of EPH-gestosis HRG-level was about the same amount like in normal pregnancies.

Adolescent↗