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Biomedical subjects

G Tanner

Publications and source records attributed to G Tanner.

15 recordsLinked to original sources
PubMed2000

Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention.

BACKGROUND & AIMS: Irritable bowel syndrome (IBS) is characterized by visceral hypersensitivity, possibly related to abnormal brain-gut communication. Positron emission tomography imaging has suggested specific central nervous system (CNS) abnormalities in visceral pain processing in IBS. This study aimed to determine (1) if functional magnetic resonance imaging (fMRI) detects CNS activity during painful and nonpainful visceral stimulation; and (2) if CNS pain centers in IBS respond abnormally. METHODS: fMRI was performed during nonpainful and painful rectal distention in 18 patients with IBS and 16 controls. RESULTS: Rectal stimulation increased the activity of anterior cingulate (33/34), prefrontal (32/34), insular cortices (33/34), and thalamus (32/34) in most subjects. In IBS subjects, but not controls, pain led to greater activation of the anterior cingulate cortex (ACC) than did nonpainful stimuli. IBS patients had a greater number of pixels activated in the ACC and reported greater intensity of pain at 55-mm Hg distention than controls. CONCLUSIONS: IBS patients activate the ACC, a critical CNS pain center, to a greater extent than controls in response to a painful rectal stimulus. Contrary to previous reports, these data suggest heightened pain sensitivity of the brain-gut axis in IBS, with a normal pattern of activation.

Adult↗
PubMed1999

Bromfenac (Duract)-associated hepatic failure requiring liver transplantation.

Bromfenac sodium (Duract) is a phenylacetic acid-derived nonsteroidal anti-inflammatory agent introduced in the United States in 1997 and withdrawn in 1998. We describe the first case of fulminant hepatic failure associated with this agent treated successfully with liver transplantation. Similarities to hepatotoxicity with related agents is discussed.

Adult↗
PubMed1998

Unemployment rates, single parent density, and indices of child poverty: their relationship to different categories of child abuse and neglect.

OBJECTIVE: There were two main research questions: First, is there a relationship between rates of child physical abuse, child sexual abuse and child neglect and levels of female and male unemployment, single-parent density and child poverty in the immediately local area; and second, is this relationship different for different categories of abuse and neglect and different categories of deprivation? METHOD: Using archival data--registered cases of abuse and neglect and official data on child population, social worker ratio, unemployment rates, single-parent density, means-tested clothing grants and free school meals for children--a multiple correlational analysis was carried out of the 5,551 referrals and 1,450 registered cases of abuse and neglect in Glasgow, Scotland for the years 1991 through to 1993. RESULTS: Substantial correlations were found with all indices of deprivation but particularly physical abuse with rates of male unemployment. Lower and more variable correlations were found with female unemployment rates. Sexual abuse and neglect rates showed a less consistent relationship with the indices of deprivation. In general male unemployment rates alone accounted for two-thirds of the variance in total abuse and neglect rates, other factors adding little or nothing to this. CONCLUSIONS: The results demonstrate the importance of selecting small and relatively homogeneous areas for this kind of analysis to achieve ecological validity. Male unemployment rates at this level allow for the ranking of areas in terms of priority need.

Child↗
PubMed1982

Pharmacokinetics of inhalation anesthetics: a three-compartment linear model.

The evolution of mathematical models of the uptake of the inhaled anesthetic agents has produced increasingly complex models in which researchers have attempted to incorporate more and more data on the effects of anesthetics on the processes of respiration, circulation, and metabolism. One result of this evolution has been to limit the application of these models due to the large amount of data required by the model and the need for a large digital computer to generate a solution. The purpose of this study is to show that a three-compartment linear model, using only the solubility of an anesthetic in water and oil, may br used to predict the uptake of a volatile anesthetic with sufficient accuracy for practical purposes. Only a programmable hand calculator is needed for the solution. Due to the simplicity of this model, compared with previously described models, it should prove useful in understanding the kinetics of gas uptake by the body.

Anesthesia, Inhalation↗
PubMed1980

Traumatic hepatic duct injury: new approach to surgical management.

Blunt traumatic injury to the biliary tract is rare, and its management is one of the most difficult and challenging problems confronting surgeons. If disruption occurs in the hepatic ducts, occult ductal injury may even go unnoticed. A high index of suspicion is the single most important factor leading to the identification and successful management of these injuries. A patient with massive upper abdominal injuries secondary to blunt trauma is reported on. Intraoperative cholangiography demonstrated bilateral hepatic duct transection. The injury was successfully managed by Roux-en-Y hepatoportal enterostomy, an approach that has not been previously reported. Primary repair or hepatic cholangiojejunostomy is the treatment of choice for hepatic duct injuries. Hepatoportal enterostomy, however, offers a satisfactory alternative in treatment when the patient is unstable or when primary repair is not possible. The literature is reviewed and the pathogenesis, diagnosis and treatment of nonpenetrating injuries to the biliary tract are discussed.

Abdominal Injuries↗
PubMed1980

[Quantitative histological observations in gliomas (author's transl)].

30 autopsy cases of gliomas (5 fusiform glioblastomas, 5 multiform glioblastomas, 5 fibrillary astrocytomas, 5 protoplasmic astrocytomas, 5 oligodendrogliomas, 5 spongioblastomas) were studied by means of morphometry. 7 parameters (volume and area parameters of tumor vessels and of tumor cell nuclei, mitoses) were tested for the ascertainament of useful quantitative criteria for the objective differentiation of the gliomas. 210 statistical comparisons were carried out. Significant differences were observed in 32 of them. It could be demonstrated that the parameters of the tumor cell nuclei are most useful in the differentiation of the gliomas. Significant differences do not exist between fusiform glioblastoma--multiform glioblastoma, fusiform glioblastoma--oligodendroglioma, fibrillary and protoplasmic astrocytoma--spongioblastoma.

Adult↗
PubMedDate not supplied

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