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Biomedical subjects

G T Zhangel'dina

Publications and source records attributed to G T Zhangel'dina.

4 recordsLinked to original sources
PubMed1979

[Structural changes of synaptic membranes under the action of specific antisera using the spin probe technique].

The spin probing technique was used to study the interaction of preparations of rat cerebral cortex synaptic membranes with specific antisera. It was found that the fluidity of membrane matrix largely depended on the nature of physiological processes involving synaptic membranes in vivo. The supramolecular structure of synaptic membranes isolated from the brain of trained animals differed from that of controls. Differences in the properties of synaptic membranes were also revealed during their incubation with specific antisera. The data obtained are interpreted in terms of immunochemical theory of memory and training.

Animals↗
PubMed1978

[Alteration of the antigenic properties of the synaptic membrane proteins of rat cerebral cortex during learning].

Rabbit antisera to the synaptic membrane fraction (SMF) of the cerebral hemispheres of control rats and animals with conditioned avoidance behaviour, reacting with the corresponding antigens in the complement fixation test, were obtained. Antibodies reacting specifically with the SMF of the brain of trained animals were revealed in the "trained" serum after the removal of antibodies to heterologous antigens and to the control SMF antigens.

Animals↗
PubMedDate not supplied

[Proteins of rat brain synaptic structures during conditioned reflex activity].

A comparative study was made of the structural-functional groups of proteins of synaptic structures in the cerebral cortex of albino rats during elaboration of a simple food-procuring reflex in one session. The results of estimation of quantitative and qualitative protein changes by the methods of isotope analysis and discelectrophoresis on polyacrylamide gel point to dissimilar changes in membrane and synapto-plasmatic proteins during learning. The process of temporary connections formation is accompanied by structural-chemical reorganizations of the synaptic membranes which evidently involve conformative transitions of external and integral proteins. There is a drastic rise in the rate of metabolism in the group of watersoluble proteins during learning, along with a possibility of "local" changes of synthesis in the fraction of low-molecular proteins.

Animals↗