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Biomedical subjects

G T Wilkinson

Publications and source records attributed to G T Wilkinson.

At least 19 recordsLinked to original sources
PubMed1989

Phaeohyphomycosis caused by Exophiala spinifera in two cats.

The dematiaceous fungus Exophiala spinifera was isolated from a cutaneous lesion on the paw of a male domestic shorthair cat and from the nasal exudate and abscess contents from a female domestic shorthair cat. Treatment with ketoconazole (10 mg kg-1 daily) resulted in improvement in the first cat but unfortunately this animal was subsequently lost to follow-up. The second cat was treated initially by the same regimen without apparent benefit. The dose of ketoconazole was subsequently increased but finally had to be discontinued when the cat developed signs of hepatotoxicity. At this stage treatment with flucytosine (150 mg kg-1 daily) was commenced. The cat improved and cultures of nasal exudate performed 8 and 16 weeks after initiation of 5-fluorocytosine therapy were negative for E. spinifera. However, the condition recurred with granulomatous tissue appearing in each nostril and abscess formation with subsequent rupture occurring on the bridge of the nose when therapy was withdrawn. These two cases constitute the first report of E. spinifera infection in animals and of this fungal infection in Australia.

Animals↗
PubMed1981

Canine angiosarcoma (lymphangiosarcoma).

After injury to the left foreleg, a 2 1/2-year-old Great Dane bitch developed severe oedema of the limb, which did not respond to pressure bandaging or a proteolytic agent. Skin breakdown occurred over the metacarpal region and lymph could be expressed from this lesion. The oedema spread, anaemia and dyspnoea developed and the animal died of respiratory insufficiency 55 days after the initial injury. Autopsy showed widespread infiltration of subcutis, fascial planes and some muscles of the leg by invasive cords and sheets of small endothelial-type cells which formed channels sometimes filled with blood. There was widespread diffuse metastatic neoplasm throughout the lung but no cavernous blood sinus formation. There were small metastases in local lymph nodes, kidney, bone marrow and spleen. It was concluded that the injury made obvious an oedema caused by pre-existing angiosarcoma.

Animals↗
PubMed1978

Chronic methylmercurialism in the cat.

The mercury levels in 69 muscle samples from fish weighing from 0.3 to 200 kg caught in Moreton Bay, Queensland, in the latter half of 1976 ranged from less than 10 to 2,030 ng/g. Mercury levels in blood samples from 53 humans and 100 dogs in Brisbane almost all contained less than 10 ng/ml while the level in 162 cats sampled ranged from less than 10 to 329 ng/ml. Chronic methylmercurialism developed in 2 cats dosed daily with methylmercury, bound to cysteine, at the rate of 0.6 mg/kg body weight for 74 and 77 days respectively. Terminal clinical signs included anorexia, weight loss, knuckling over at the carpus and tarsus, hypermetria initially involving the forelegs and later the hindlegs, sluggish reflexes, paresis involving all limbs, persistent crying, apparent blindness, tonic and clonic convulsions and salivation. Pathological changes were confined to the nervous system and included degeneration of neurones and perivascular cuffing in the cerebrocortical grey matter, focal atrophy of the granular layer, focal spongiosus of the molecular layer and degeneration and loss of Purkinje cells in the cerebellum and demyelination in the fibre tracts of the dorsal funiculus, mainly the fasciculus cuneatus and in the lateral and ventral corticospinal tracts. Terminal blood methylmercury levels were in excess of 18 microgram/ml, while brain methylmercury levels ranged from 21.0 to 28.4 microgram/g. The liver and kidney contained the highest total levels of mercury of 50 to 80 microgram/g, of which 23 to 37% was inorganic.

Animals↗
PubMed1977

Coccidial infection in a cat colony.

The significance of coccidiosis in the cat is discussed and the clinical signs of infection are described. The occurrence of subclinical infection with Isospora felis in 49 of 58 cats in a colony is reported. Treatment with a 20% solution of sulphadimethoxine at a dose rate of 50 mg per kg bodyweight, administered in the food daily for 14 days, was successful in eradicating the infection. Sulphadimidine appeared to have no effect on the number of oocysts in the faeces of one cat. Ancillary hygienic measures included the use of disposable feeding and drinking utensils, frequent removal and destruction of faeces and scrubbing of sanitary trays and cages with hot 5% sodium carbonate solution.

Animals↗