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Biomedical subjects

G T Singleton

Publications and source records attributed to G T Singleton.

At least 19 recordsLinked to original sources
PubMed1988

Correlations between hearing thresholds and caloric responses among a heterogeneous sample of dizzy patients.

Auditory and vestibular function were compared in a heterogeneous sample of dizzy patients (N = 52). Hearing thresholds for the conventional audiometric frequencies were measured for each patient and parceled into two frequency ranges, 0.25-1 kHz and 2-8 kHz. Hearing thresholds also were measured for each patient over an extended high-frequency range that included the frequencies 10, 12, and 14 kHz. Bithermal caloric responses for these patients were available and were grouped for unilateral weakness (UW) or no unilateral weakness (NOUW). Hearing thresholds ipsilateral to the side of unilateral weakness (UW) yielded significant (p less than .05) modest correlations (r = .39-.52) with UW for all three audiometric frequency ranges (N = 35). These findings do not suggest a strong tonotopic relation between the audiometric and UW data. Hearing thresholds for the frequency range 10-14 kHz, but not for the conventional audiometric frequencies, correlated with slow-phase eye velocity (SPV) when SPV was averaged across the four caloric conditions for each of 17 NOUW patients. The latter finding indicates a subtle trend for eye velocity to increase as a function of increasing hearing threshold.

Adolescent↗
PubMed1986

Diagnosis and treatment of perilymph fistulas without hearing loss.

In 1978, I reported on the diagnostic criteria and therapy based on the treatment of 34 cases of perilymph fistula. Of that group, 20 patients had no hearing loss associated with the fistula. Since that time, an additional 30 cases of fistula--15 without hearing loss--have been seen and treated operatively. The 30 significant variables of history and physical findings identified in the first study were statistically reviewed, along with a new finding that seems highly significant. Twenty-three of the 26 new cases so evaluated had a positive "eyes-closed turning test" (staggering when turning to the side of the lesion after walking with eyes closed). A further finding has been the presence of an abnormally placed round window membrane, in most cases involving the round window. The total operative population of fistulas, both those with and without hearing loss, is reviewed to identify the operative technique best suited for each window and the graft material most likely to succeed. Perichondrium is the choice tissue for graft material, except for very small fistulas at the annular ligament. The graft must be held firmly in place, with either a prosthesis or appropriate packing, carefully avoiding adhesions between the round window and the tympanic membrane.

Adolescent↗
PubMed1986

Meniere's disease.

Explore the source record for details and available documents.

Combined Modality Therapy↗
PubMed1982

Chemodectomas arising in temporal bone structures.

Eighteen patients with chemodectomas arising in temporal bone structures were evaluated and treated at the University of Florida. Seventeen patients have each been followed a minimum of 3 years. Patients were retrospectively staged as having "local" or "advanced" disease, depending on the presence or absence of bone destruction and/or cranial nerve involvement. Fourteen of the patients received radiation therapy as all or part of their therapy; 6 patients were treated with radiation therapy alone, 3 patients were irradiated immediately postoperatively for residual disease, and 5 patients had radiation therapy for recurrence after operation. They were treated with cobalt-60 radiation with doses ranging from 3760 to 5640 rad. All irradiated patients demonstrated evidence of tumor regression, and none have had tumor recurrence with followup of 3-12 years. Of the 8 patients with cranial nerve paralysis prior to therapy, 5 had return of function of 1 or more cranial nerves. One of 6 patients treated initially with radiation therapy had a complication, while 6 of 8 patients irradiated postoperatively had complications. None of the complications were fatal. Three patients treated by operation for early disease limited to the hypotympanum had the disease controlled for 11-12 years. Guidelines for the selection of initial therapy are discussed.

Humans↗
PubMed1976

Ossicular fixation to the tegmen.

Two surgical techniques are presented for the treatment of ossicular fixation of the incus and malleus to the tegmen. One involves an atticotomy approach, the second a mastoid approach to the attic.

Ear Ossicles↗
PubMed1975

Effect of coronal plane tilt on cat caloric nystagmus responses.

The nystagmus slope responses to vestibular stimuli are strongly dependent on eye position, while the frequency responses shift predictably and are relatively independent of the eye position. Spurious directional differences may be introduced in nystagmus slope parameters by small tilts in the roll plane in comparison to the more predictable frequency responses.

Animals↗