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Biomedical subjects

G T Simon

Publications and source records attributed to G T Simon.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Cell junctions in lymphomas: study of a primary ovarian T-cell lymphoma and review of fifty-six other cases of lymphoma.

A case of primary ovarian lymphoma was studied by light microscopy, immunohistochemistry, and electron microscopy. The ultrastructural study revealed the presence of cell junctions of the paired subplasmalemmal densities and tight junctions between adjacent lymphoid cells. Fifty-six cases of non-Hodgkin's lymphoma randomly selected from the files of the Electron Microscopy Facility of the Faculty of Health Sciences, McMaster University, were reviewed. Paired subplasmalemmal densities and tight junctions were identified in five of the cases (9%). This study suggests that the absence of cell junctions should not be considered an essential criterion for the ultrastructural diagnosis of lymphomas.

Cytoplasm↗
PubMedDate not supplied

Apatite determination and distribution in an early stage of gallbladder calcification.

This study is concerned with the nature and distribution of mineral in the gallbladder of a patient with chronic cholecystitis. Light and electron microscopic imaging revealed the mineral to be in the epithelial cells of the mucosa and fibroblasts of the submucosa. In the epithelial cells at the early stages of deposition, mineral was located in the nuclei and throughout the cytoplasm in association with interdigitating cell processes and apical microvilli but was absent in mitochondria. Elemental and electron diffraction analyses indicated the mineral inclusions to be apatite in nature.

Adult↗
PubMedDate not supplied

Diagnostic electron microscopy laboratory of the future.

The future of diagnostic electron microscopy is intimately related to the introduction of techniques presently used in basic research, the introduction of new technologies and instrumentation, the availability of expertise, and monetary constraints. It is suggested that a certain degree of centralization of diagnostic electron microscopy is inevitable if one wishes to introduce state-of-the-art technologies and maintain a high degree of expertise.

Clinical Laboratory Techniques↗
PubMedDate not supplied

Oligodendroglioma with granular cells: a case report.

Oligodendrogliomas can display a spectrum of histologic and ultrastructural features. The authors describe a case of an oligodendroglioma composed almost exclusively of eosinophilic granular cells. By electron microscopy, the tumor cells had abundant lysosomes containing electron-dense pleomorphic material. Although eosinophilic granular cells can be seen focally in oligodendrogliomas, it is unusual for them to pre-dominate. By light microscopy alone, such an appearance raises a broad differential diagnosis that electron microscopy can help resolve. In addition, the ultrastructural similarities between this tumor and granular cell tumors in general support the idea that granular cell neoplasms are a phenotype expressed by a wide variety of cells.

Brain Neoplasms↗