Search PubMed⌕ Search

Biomedical subjects

G T STEWART

Publications and source records attributed to G T STEWART.

At least 37 records · Page 2Linked to original sources
PubMed1961

Excretion and re-excretion of a broad-spectrum penicillin in bile.

A technique is described for estimating the biliary excretion, reabsorption and re-excretion of an antibacterial drug in rats. D(-)-6-(alpha-Amino-alpha-phenylacetamido)-penicillanic acid (BRL 1341) is rapidly excreted and re-excreted in the bile, in concentrations bactericidal to Salmonellae and other organisms which are usually refractory to antibacterial drugs in this situation. Recoveries of the drug accounted for 20 to 30% of oral of parenteral doses; much of the remainder is probably destroyed in the gut. Results from one patient indicate that D(-)-6-(alpha-amino-alpha-phenylacetamido)-penicillanic acid is excreted in high concentration also in human bile.

Ampicillin↗
PubMed1961

Excretion of antibiotics in bile.

The excretion of antibiotics in the bile of rats has been studied. Penicillins, including derivatives of 6-aminopenicillanic acid, are rapidly excreted, reabsorbed and re-excreted, in high concentration, whereas streptomycin, neomycin, paramomycin and chloramphenicol reach lower levels in the bile than in the plasma. p-Aminobenzylpenicillin and D(-)-6-(alpha-amino-alpha-phenylacetamido)penicillanic acid, both of which are bactericidal to Salmonellae and other coliforms, produce higher concentrations in the bile than benzylpenicillin (penicillin G). This may be of therapeutic importance.

Ampicillin↗
PubMed1961

Paromomycin.

Explore the source record for details and available documents.

Anti-Bacterial Agents↗
PubMed1960

The excretion of sodium 6-(2,6-dimethoxybenzamidopenicillanate) monohydrate in rats.

The excretion of sodium 6-(2:6 dimethoxybenzamido) penicillanate monohydrate has been studied. When injected intramuscularly it was rapidly excreted in the bile and urine of rats, but only in trace amounts in the faeces. The excretion products in the bile (2 to 3% of the dose) and urine (26-84% of the dose) are microbiologically active. The product in the bile may be in conjugated form.

Animals↗