Comparative studies of T-lymphocyte antigens in the rat: are ART, Ly, Pta, and Ag-F the same?
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Biomedical subjects
G T Rasmussen
Publications and source records attributed to G T Rasmussen.
An animal model for the study of prostate carcinoma.
We report here the development of the Dunning R-3327 prostate adenocarcinoma of the Copenhagen rat as a suitable model of human prostate cancer. Tumors, produced by sc or intraprostate injection of viable cells, had the macroscopic and microscopic characteristics of the human disease. The histologic picture of these tumors was of a well-differentiated adenocarcinoma with the formation of glands and acid secretions within the acini. The intraprostate tumor, although initially confined to the injected lobe, grew to involve the surrounding tissues and eventually metastasized to the lymph nodes and lungs. Occasional metastatic lesions were found in other organs as well. During investigation of the tumor, a fast-growing line arose that grew equally well in females as in males. The histology of this tumor was of an undifferentiated anaplastic tumor. A tissue culture line derived from R-3327 was capable of producing tumors in recipient rats with characteristics similar to the original Dunning tumor.
Adenocarcinoma↗
Evidence from capping experiments for independence of the RT7 alloantigen and the leucocyte common antigen in the rat.
Experiments reported here demonstrate that the RT7 alloantigen and the L-C antigen are separate and distinct structures on the surface of rat lymphocytes. The distribution of the antigens in different rat strains, including the mutant WF/fz, clearly establish the RT7 antigenic system as a polymorphic diallelic system, whereas the recognized L-C antigenic determinant is monomorphic and present on the lymphocytes of all rat strains tested. These data were obtained using monoclonal antibodies to the antigens in indirect immunofluorescence experiments. The two antigens were shown to redistribute (cap) independently of one another on the surface of rat thymocytes. Cells that had been exposed to anti-L-C antibody and FITC-conjugated anti-Ig followed by anti-RT7.1 antibody and RITC-conjugated anti-Ig demonstrated FITC caps and RITC rings.
Animals↗