Biomedical subjects
Publications and source records attributed to G T Matioli.
Stochastic and field models of hemopoietic stem cell renewal are tested for quantitative predictions regarding limited survival of mouse stem cells during serial transplant from donors into lethally irradiated recipients. Besides circumventing the limitations of stochastic theories, the field model is found to be congruent with experimental data.
We discuss a "genomic" mechanism capable of yielding clonal malignancies (e.g. hemopoietic leukemias) without the prerequisite of multiple or single mutations. This hypothetical mechanism is based upon the anachronistic (illegal) expression of a special gene P, where P stands for "potential". P. is a stimulus promoting renewal of stem and most immature cells of hemopoietic tissues. In normal conditions, these cells renew themselves only after receiving P from special microenvironmental cells or field "sources". When illegally expressed by a previously dependent cell, the autocatalyzed potential competes with differentiating factors and slows down terminal differentiation. This sets the cell on a temporary (or extended) "limit cycle" between competing attractors viz: renewal and extinction, whereby both progenitor and clonal progeny are locked between continuous proliferation and terminal differentiation for a time longer than their normal, absolutely source dependent counterparts.
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A technique for electrophoretic analysis of the hemoglobin mixtures from single erythrocytes has been developed. Hemoglobin mixtures were separated into their constituents, A(2), A, C, S, and J, at least qualitatively.
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The paper discusses a system of hinged leverages functioning as (vectorial) pantographic motors (PMs). Mediated by ratchets, PMs are suited for ferrying mammalian chromatids to mitotic antipoles. Several self-rectifying modes allow PMs to accurately partition genomes with minimal risk of engendering aneuploidy.
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