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Biomedical subjects

G Swanbeck

Publications and source records attributed to G Swanbeck.

At least 91 records · Page 5Linked to original sources
PubMed1976

Ultraviolet-induced dna repair synthesis in lymphocytes from patients with actinic keratosis.

Actinic keratosis is an epidermal cancer in situ. Extensive exposure to sunlight is considered as a contributing factor to the etiology of this tumor. Ultraviolet (UV) light of solar radiation induces structural damage in DNA, which may give rise to mutations and transformed cells if the damage is not repaired. Repair of UV-induced DNA lesions is an essential property of human cells. The conditions so far reported to have defective DNA repair are all associated with an increased incidence of malignancy. Do patients with actinic keratosis also exhibit a reduced capacity to repair UV-induced DNA lesions? DNA repair synthesis in peripheral leukocytes was studied in 10 patients with actinic keratosis and 10 healthy subjects of corresponding age. After irradiation with various doses of UV light the leukocytes were incubated for 2 hr with [3H]thymidine in the presence of hydroxyurea. A dose-response relationship for the UV-induced DNA repair synthesis was established for each individual. The average repair capacity in the patients with actinic keratosis was about 30% below that of the controls. The difference is statistically significant (p less than 0.02). Reduced DNA repair synthesis may therefore be an important factor in the etiology of actinic keratosis.

Aged↗
PubMed1975

Treatment of psoriasis with oral psoralens and longwave ultraviolet light. Therapeutic results and cytogenetic hazards.

The purpose of the present investigation was to study the usefulness of oral treatment of psoriasis with psoralens and longwave ultraviolet light and the possible cytogenetic hazards of this therapy. 8-methoxypsoralen (8-MOP) in doses between 15 and 60 mg orally followed 2 hours later by UVA irradiation of one side of the body gave a healing of the irradiated side in 24 of 40 cases and an improvment in another 11 cases while only one case healed on the side of body that was not irradiated. The most common undesired side effect was pruritus on the irradiated side of the body. The cytogenetic study showed that 8-MOP and UVA treatment of lymphocytes in vitro gives rise to chromosomal aberrations. In a combined in vivo-in vitro study where the lymphocytes had been isolated from a patient 2 hours after intake of 60-80 mg 8-MOP and then irradiated with therapeutic UVA doses, a significant increase in chromosomal aberrations was found. When chromosome analyses were made on the patients whilst the 8-MOP treatment was temporarily withdrawn and when the lymphocytes were not irradiated in vitro, no increased frequency of chromosomal abberations was found on comparison with a group of psoriatic patients receiving dithranol therapy.

Administration, Oral↗