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Biomedical subjects

G Swanbeck

Publications and source records attributed to G Swanbeck.

At least 55 records · Page 3Linked to original sources
PubMed1987

Prevalence of hand eczema in an industrial city.

The occurrence of hand eczema in an industrial city was studied. Questionnaires were sent to 20,000 individuals aged 20-65 years, randomly selected from the population register of the city. After two reminders, a response rate of 83% was obtained. Analysis of the drop-outs did not indicate that the presence of hand eczema was an important selection factor for response to the questionnaire. Those subjects considering themselves to have had hand eczema within the previous 12 months were invited to a dermatological examination to verify the diagnosis and for further investigation. Seventy-one per cent accepted the invitation. Analysis of drop-outs showed that willingness to attend the dermatological examination was to some extent dependent on the severity of the hand eczema. It was found that almost 11% considered themselves to have had hand eczema at some time during the previous 12-month period; approximately two thirds were women. Five point four per cent had had hand eczema at a particular point in time (prevalence) and 2% had had continuous problems with hand eczema during the previous year.

Adult↗
PubMed1987

Chronic eczematous dermatitis of the hands: a comparison of PUVA and UVB treatment.

The efficacy of PUVA and UVB treatment in chronic eczematous dermatitis of the hands was compared in a randomised controlled study including 35 patients who were randomly allocated to PUVA or UVB treatment. One hand was exposed to light and the other served as an untreated control. The dermatitis cleared on the treated hand in all PUVA patients, but in 9 out of 14 there was a relapse within three months. In the UVB group clearing of the skin lesions was not achieved, but compared with the "untreated" hands a statistically significant improvement was found at 12 weeks of treatment. A statistically significant improvement of "untreated" hands was found in both groups. PUVA and UVB treatments are alternative treatment modalities in patients with recalcitrant chronic eczematous dermatitis of the hands. PUVA is superior to UVB.

Clinical Trials as Topic↗
PubMed1987

Fungal infections occurring under bandages in leg ulcer patients.

In 49 consecutive leg ulcer patients fungal cultures were taken from 4 different locations: the ulcer; the ulcer edge; 10 cm below the knee; and the toe-web. The patients had been treated with ACO Medicated Stockings in half of the cases, and the others were treated with several different bandages. Sera were analysed for antibodies against Candida albicans with the indirect immunofluorescence technique (IIF). The mean antibody titer was 434 in the patients with C. albicans in their ulcers, 123 in control patients with negative cultures in their ulcers and 258 in control patients with basalioma or actinic keratoses. Seven patients were culture positive for C. albicans, two patients had C. parapsilosis and one had growth of Trichophyton rubrum in their ulcers. Nine out of 10 patients with positive cultures had been treated with ACO Medicated Stockings (p less than 0.05). Covering a large area of the leg with an ointment impregnated stocking without preservatives seems to increase the risk for fungal infections.

Adult↗
PubMed1987

A follow-up study of leg and foot ulcer patients.

Three hundred and fifty patients treated in 1980 at the Department of Dermatology for leg and foot ulcers were asked to come for an interview concerning the development of their ulcerations up to the end of 1983. Forty-five of 186 patients were free from ulcers from 1981 to 1983. Thirty patients had leg ulcers continuously throughout the period and their ulcers were not healed at any time. Ninety-six patients had died during the follow-up period, and the total mortality rate compared to an age-matched population was shown to be approximately doubled for both men and women. When analysing the causes of death, it was found that the ischemic heart disease mortality rate was twice that of the age-matched population but the mortality rate for malignant diseases was about the same.

Adult↗
PubMed1986

A mother and two children with nonbullous congenital ichthyosiform erythroderma.

A mother and her two daughters were all afflicted by congenital nonbullous ichthyosis. The clinical and ultrastructural picture are in accordance with recessive congenital ichthyosiform erythroderma. The mode of inheritance for the children is assumed to be by pseudo-dominance. Nonbullous congenital ichthyosiform erythroderma and lamellar ichthyosis are probably heterogeneous.

Adult↗
PubMed1985

Candida albicans infections in leg ulcers and surrounding skin after the use of ointment impregnated stockings.

Six elderly women treated with double elastic bandages for chronic venous leg ulcers presented a clinical picture beneath these bandages as seen in intertriginous candidiasis. Painful, bright red, glistening skin lesions with pustules, denuded skin and scales were seen. Cultures on Sabouraud's agar from skin erosions and toe webs confirmed the suspicion of Candida albicans infection. Treatment with topically applied clotrimazole cream resulted in relief of pain and healing of skin lesions. There is a possibility of the Candida albicans having been transmitted from the toe webs by the bandages, and that the bandages creates a microenvironment suitable for growth of the yeast.

Aged↗
PubMed1984

The effect on psoriasis of clobetasol propionate used alone or in combination with UVB.

A study has been carried out to compare the effect of a combination of clobetasol propionate and UVB versus placebo/UVB. No significant reduction in time to healing was observed. However, symptoms abated more rapidly in the steroid/UVB group. Recurrences occurred at an earlier stage following the steroid UVB combination for long periods. A third group, treated solely with clobetasol propionate has also been investigated, but results were poorer than those described above. It is concluded that steroids in combination with UVB should be used only during the initial period in order to achieve a more rapid alleviation of symptoms and to avoid the side effects.

Betamethasone↗
PubMed1984

Leg and foot ulcers. An epidemiological survey.

Medical records for leg and foot ulcer patients have been investigated, 1377 patients were found. The median age for women was 76 years and for men 70 years. Totally there was a majority of women, 61%. The age specific frequencies for leg and foot ulcer patients did however not differ between men and women. Thirty percent of all patients had ulcers on the feet only. The ratio between men and women for feet ulcers was 1:1. Men got their feet ulcers 5-10 years earlier than women. Seventeen percent of all patients had ulcers on the medial side of the calf only. Seventy percent of these patients were women. A rough estimate of the prevalence of leg and foot ulcer patients was made to between 0.2-0.4% of the whole population. The involvement of different medical disciplines in the care of leg and foot ulcer patients in Gothenburg is reported.

Adult↗
PubMed1984

To UVB or not to UVB?

Explore the source record for details and available documents.

Carcinoma, Squamous Cell↗
PubMed1983

Studies of DNA and chromosome damage in skin fibroblasts and blood lymphocytes from psoriasis patients treated with 8-methoxypsoralen and UVA irradiation.

Exposure of human lymphocytes and skin fibroblasts in vitro to a single, clinically used dose of PUVA, i.e., 0.1 micrograms/ml of 8-methoxypsoralen (8-MOP) plus 0.9-4 J/cm2 of longwave ultraviolet radiation (UVA), lead to the formation of DNA damage as determined by alkaline elution, and to chromosome aberrations and sister chromatid exchanges (SCE). When lymphocyte-enriched plasma was obtained from psoriasis patients 2 h after oral intake of 8-MOP and then UVA irradiated (1.8-3.6 J/cm2) in vitro, an increased frequency of chromosome aberrations and SCE was observed. Normal levels of chromosome aberrations and SCE were found in lymphocytes of psoriasis patients after 3-30 weeks of PUVA treatment in vivo. A small but statistically significant increase in the SCE frequency was observed in the lymphocytes of psoriasis patients treated for 1-6 years with PUVA (mean 18.0 SCE/cell) as compared with before PUVA (mean 15.8, p less than 0.05). Skin fibroblasts of psoriasis patients analyzed 5 years after the start of PUVA treatment showed a normal number of SCE but a high fraction of filter-retained DNA in the alkaline elution assay, suggesting the presence of cross-linked DNA.

Chromosome Aberrations↗
PubMed1983

PUVA treatment of alopecia totalis.

40 patients with alopecia totalis have been treated with PUVA. 26 did not respond, 6 experienced a partial hair regrowth, while 8 got a complete regrowth. However, relapses were frequent, occurring at an early stage.

Adult↗
PubMed1982

Psoriasis treatment and a day-care centre: clinical aspects and an attempt at a cost-benefit analysis.

The practical results of day-care centre treatment of psoriasis have been studied. Patients referred to the centre are generally those where the skin disease covers substantial body areas. The main treatment has been UVB. UVB plus dithranol or PUVA has been used on patients who have failed to respond to UVB alone. With UVB therapy alone, 263/328 patients healed with a median to healing time of 8 weeks, and 9 weeks to relapse. 34/60 patients with a previously poor response to UVB healed on UVB plus dithranol. Median time to healing was 8 weeks and time to relapse, 12 weeks, 24 patients were treated with PUVA, as they had had a poor earlier response to UVB. All healed with a median time to healing of 12 weeks and 25 weeks to relapse. 3.3% of the patients fit for work have at some time during the treatment been off work due to their psoriasis. The cost for this type of treatment is about one-fifteenth of the cost of treatment on a hospital ward.

Adolescent↗
PubMed1982

Is UVB treatment of psoriasis safe? A study of extensively UVB-treated psoriasis patients compared with a matched control group.

The aim of the study was to investigate whether or not extensively UVB-treated psoriatics ran a greater risk of developing skin cancer than did controls. The 85 most extensively UVB-treated psoriasis patients during recent decades have been investigated with regard to premalignant and malignant skin lesions and compared with a population matched for age, sex, and geographic region. The prevalence of persons who had or had had premalignant/malignant skin lesions was 5.9% (n = 85) in the psoriasis group, vs. 10.1% in the control group (n = 338). This difference is not statistically significant and the confidence limits are such that it is unlikely that the psoriasis patients treated in the past have an increased prevalence of premalignant and malignant skin lesions. A multiple regression analysis has been conducted among the controls, showing a correlation between premalignant/malignant skin changes and advanced age and outdoor occupations. No such correlation was found for the factors: sex, skin type, or travel to southern latitudes.

Adult↗