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Biomedical subjects

G Swan

Publications and source records attributed to G Swan.

6 recordsLinked to original sources
PubMed1998

Virus inactivation by solvent/detergent treatment and the manufacture of SD-plasma.

Solvent/Detergent (SD) is an extraordinarily effective means for eliminating enveloped viruses from plasma and plasma products. The safety margin suggested by the rapid and complete kill of enveloped viruses observed in the laboratory has been confirmed repeatedly by groups worldwide and by thirteen years of routine clinical use encompassing an estimated 35 million doses of a wide variety of products. Throughout this time, there has not been a single documented case of enveloped virus transmission by an SD-treated product. This record of safety spawned the development of SD-treated plasma as a substitute for fresh frozen plasma (FFP) and has encouraged the adoption of SD for the treatment of non-blood products such as monoclonal antibodies and those derived from recombinant DNA procedures. This review summarizes the use of SD treatment, including its use in combination with other viral elimination procedures, and also summarizes Vitex's initial experience in the manufacture of SD-Plasma, recently licensed by the U.S. FDA.

Blood-Borne Pathogens↗
PubMed1996

Society for Research on Nicotine and Tobacco.

The proceedings of the inaugural scientific meeting of the Society for Research on Nicotine and Tobacco (SRNT) are summarized. The primary objective of the meeting was to foster the exchange of information on the effects of nicotine and tobacco use, as well as factors which influence their use, drawing from biological, behavioral and social sciences. Much of this research can be viewed as a tale of "two" drugs--nicotine as a key to an important public health problem, and nicotine as a classical tool of physiological and pharmacological research. A historical overview of research on "both" drugs is provided first. Public policy alternatives for reducing the prevalence of tobacco use have been derived in part from basic and clinical research results and are briefly outlined. Evidence for genetic determinants on nicotine use and effects is presented using data from twin studies and from molecular genetic research with humans and animals. Consistent with this research, there is evidence of individual differences in pharmacokinetics and effects of nicotine, which could account for differences in smoking behavior and nicotine dependence. Finally, recent developments in the therapeutic uses of nicotine and novel nicotinic agonists with schizophrenia, Alzheimer's disease, Parkinson's disease, Tourette's syndrome and ulcerative colitis are presented. Overall, the research presented at the meeting demonstrated the vast diversity of areas of study involving nicotine and tobacco, as well as the rich opportunities for cross-communication among researchers from different disciplines.

Animals↗
PubMed1991

Long-term changes in Type A behavior: a 27-year follow-up of the Western Collaborative Group Study.

This study examined the long-term stability of Type A behavior pattern in the Western Collaborative Group Study for 1180 surviving participants in a 27-year follow-up examination during 1986-1987. Subjects were readministered the Structured Interview (SI), originally developed for this study and first administered at intake in 1960-1961. Subjects were also given the Jenkins Activity Survey (JAS) and were asked to evaluate their behaviors currently and in the past using two short descriptions of Type A and Type B behaviors. Analyses of changes in global SI ratings, JAS score, and self-ratings showed no relationships between self-perceived changes reported in questionnaires and observed changes when assessed by the SI. Using the SI ratings, 61% of subjects retained their initial classification and 39% of subjects were rated differently, with a higher percentage of those originally typed B being rerated as A than A being rerated as B. Type B subjects rerated as A were significantly younger, retired earlier, reported better health, and were less likely to have been in a managerial or professional position than the subjects who changed from A to B.

Adult↗
PubMed1978

ASSESS: Adjustment Scales for Sociometric Evaluation of Secondary-School Students.

The Adjustment Scales for Sociometric Evaluation of Secondary-School Students (ASSESS) was designed to assess peer ratings of the behavior of male and female adolescents. Five scales were developed and cross-validated: Aggression-Disruptiveness, Withdrawal, Anxiety, Social Competence, and Academic Difficulty. Evidence of adequate internal consistency and test-retest reliability was presented. Evaluations by male and female classmates were highly correlated. Sex and age differences accounted for only a small proportion of the total variance.

Achievement↗