Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast.
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Breast↗
Biomedical subjects
G Svensson
Publications and source records attributed to G Svensson.
[Conference on medical ethics - health care's evaluation problem - great need for team work].
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Ethics, Medical↗
Treatment of vasomotor rhinitis with intranasal disodium cromoglycate (SCG). Results from a double-blind cross-over study.
The effect of SCG powder (Lomudalr, Intalr) intranasally in vasomotor rhinitis has been studied on 49 adult volunteers in a double-blind cross-over study during 13 weeks in January--April 1973. The dose of SCG was 40 mg/day. Although a substantial number of results were obtained, no significant difference between the effects of SCG and placebo treatment, on variables measured, was detected. However, some patients experienced relief with, and preferred, the treatment with SCG. The results from this investigation are discussed in comparison with those from other studies including patients with vasomotor rhinitis.
Administration, Intranasal↗
Treatment of vasomotor rhinitis with intranasal beclomethasone dipropionate (Becotide). Results from a double-blind cross-over study.
The effect of beclomethasone dipropionate (Becotide) intranasally in vasomotor rhinitis has been studied on 39 adult volunteers in a double-blind cross-over study during 9 weeks in February-April 1975. The dose of beclomethasone dipropionate was 300 mug/day. Twenty-five patients preferred the beclomethasone dipropionate period, 5 patients the placebo period, and 9 patients had no preference. About three-quarters (74 per cent) of the patients considered themselves free of symptoms or greatly improved after the treatment with beclomethasone dipropionate. Statistical calculation of the daily nasal symptoms score confirms the improvement. The speediest effect was registered for sneezing, followed by nasal catarrh, nasal itching, and blocking. No changes in the levels of cortisol occurred during the treatment. The bacteriological and mycological findings (analysed with regard to Candida albicans) were fairly constant.
Adult↗
An open assessment of lomudal (disodium cromoglycate) (2 per cent) nasal spray in seasonal allergic rhinitis.
The effect of Disodium cromoglycate (Lomudal, Intal) on allergic rhinitis, given as a solution in a nasal spray, was studied in 23 adult volunteers with grass pollen allergy, none of whom were having hyposensitization therapy. The trial was carried out as an open assessment during the months of June and July, 1972. Two squirts (1.6 mg D.S.C.G.) from the nasal spray were applied to each nostril every 3 h throughout the day. In 80 per cent of subjects the treatment was successful. No side effects were noted, but five patients expressed a preference for a preparation that could be administered at less frequent intervals.
Adolescent↗
Cutaneous reactions to pollen extracts in patients with hay fever. Special references to grass pollen recommended for treatment in fixed combination.
Skin reactivity to 8 common grass pollens was investigated in patients with hay fever using commercial, unfractionated extracts in serial dilution technique. The highest degree of sensitivity was observed for cocksfoot, meadow fescue, meadow foxtail, rye grass, timothy and Yorkshire fog. Five of those are included in the Allpyral 5-Grass Mix. The cutaneous responses to rye grass pollen overlap with those to timothy in a high degree.
Adolescent↗
An open assessment of becotide (beclomethasone dipropionate) nasal spray in seasonal allergic rhinitis.
The effect of beclomethasone dipropionate (Becotide) intranasally on hay-fever has been studied in 38 adult volunteers with grass pollen allergy. The trial was carried out as an open assessment with simultaneous pollen count during the months of June and July, 1974. With the dose 300 mug/day intranasally, 95 per cent of the subjects regarded the treatment as successful for the nasal symptoms. No effect on eye symptoms was recorded, and no evident side-effects were noted.
Administration, Intranasal↗
The effect of anesthetic gases on the psychomotor and perceptual functions of anesthetic nurses.
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Adult↗
[Side effects and especially uterine bleeding in women taking oral contraceptives].
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Adolescent↗
Hemodynamic effects of ICI 118.587 (Corwin) in patients with mild cardiac failure after myocardial infarction.
The aim of this study was to compare the effects of intravenous ICI 118.587 (Corwin), a new cardioselective partial beta-agonist, and placebo given q. 12 h for 4 consecutive days, with invasive and noninvasive methods. Twelve patients with mild to moderate cardiac failure after a myocardial infarction were studied. We could not show any significant effect of Corwin on hemodynamics, systolic time intervals, heart rates, or blood pressures. We conclude that Corwin does not affect left ventricular function, as measured by hemodynamics and systolic time intervals, in the immediate postinfarction period in patients with mild to moderate heart failure.
Adrenergic beta-Agonists↗
Repeated computed tomography during treatment of small cell carcinoma of the lung.
Twenty-three patients with small cell carcinoma of the lung were examined with CT and conventional chest radiography before treatment, 19 after 3 courses of chemotherapy, before radiation therapy, and 8 after cessation of chemotherapy and radiation therapy. In most patients high abdominal CT was also employed. CT provided more information about the thoracic involvement than did conventional radiography in more than half of the cases. In 3 cases CT before irradiation demonstrated progression in the thorax, not visible at conventional radiography, and in 4 cases progression of extrathoracic metastases in spite of intrathoracic regression. After therapy, one case of progression in the thorax not seen at conventional radiography was demonstrated. With repeated CT examinations of the thorax and abdomen, progression/regression both intra- and extrathoracically is well demonstrated.
Adult↗
Effects of topical use of beta-adrenoceptor stimulants of nasal mucosa. Rhinomanometric evaluations in experiments with terbutaline and KWD 2131.
The effects of nasal airway resistance of the beta-adrenoceptor stimulants terbutaline (Bricanyl) and KWD 2131 intranasally have been studied by means of posterior rhinomanometry in 16 healthy volunteers and 13 asymptomatic patients with allergic rhinitis. The study was performed as randomized, placebo-controlled, double-blind crossover trial. No obvious changes in nasal resistance were revealed. This makes the nasal muscosa a suitable organ for testing the capacity of beta-adrenoceptor stimulants to reduce the release of mediators from mast cells after allergen challenges.
Administration, Topical↗
Influence of a beta-adrenoceptor stimulant, KWD 2131, in nasal histamine provocation tests. Rhinomanometric evaluations in normal persons and patients with hay fever.
Nasal histamine provocation was performed in ll asymptomatic (out of season) patients with hay fever and in ll normal controls. Posterior rhinomanometry was used for objective evaluation. The histamine challenges caused nasal symptoms as well as increased nasal airway resistance. The differences in response between the two groups of subjects were not significant. KWD 2131, a beta-adrenoceptor-stimulating drug which was ascribed an antiallergic effect in a previous allergen provocation study, did not block the effects of histamine challenge in a randomized, placebo-controlled, double-blind, crossover evaluation. The absence of protective action against histamine-induced effects with KWD 2131, supports a mast-cell-stabilizing effect of the substance in allergen provocation.
Adolescent↗
Dose-response relationship of a topical nasal decongestant: phenylpropanolamine.
By means of anterior rhinomanometry, the decongestant effect of topically applied phenylpropanolamine (PPA) was evaluated in 40 patients with nasal obstruction. A dose-response relation was obtained for 0.5, 2.5 and 5.0% PPA solution, with the maximum effect (40% decongestion) found with the 2.5% solution. The decongestant effect was comparable to that induced by physical exercise (50% decongestion). It is concluded that PPA nose-drops are effective and offer an attractive alternative to some of the commonly used nasal decongestants.
Administration, Topical↗
Rationale for use of local hyperthermia with radiation therapy and selected anticancer drugs in locally advanced human malignancies.
The addition of local hyperthermia to radiation therapy has significantly improved the ability of oncologists to control superficial malignancies. Large tumours, tumours which cannot be heated adequately, and those situated in areas where surrounding normal tissues have decreased radiation tolerance, however, are difficult to eradicate even with this combination treatment. We believe that properly selected and scheduled anticancer drugs will add substantially to the efficacy of local hyperthermia and radiation. A review of the literature concerning the cytotoxic interactions of various anticancer agents with hyperthermia, with radiation and with relevant physiological parameters is presented. From this review, anticancer drugs which are good candidates for trimodality therapy are identified and a general approach to trimodality scheduling is suggested.
Animals↗