Biomedical subjects
G Sutton
Publications and source records attributed to G Sutton.
Electric Medicine and Mesmerism.
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Rosamicin, a macrolide with in vitro activity against Ureaplasma urealyticum.
A new macrolide antibiotic, rosamicin, was shown to have much greater activity in vitro against ureaplasmas isolated from humans than erythromycin or the tetracyclines tested. A marked ureaplasmacidal effect was also shown.
The 'rapid filling wave' of the apex cardiogram. Its relation to echocardiographic and cineangiographic measurements of ventricular filling.
In order to study the relation between the 'rapid filling wave' of the apex cardiogram and left ventricular filling, simultaneous apex cardiograms, phonocardiograms, and echocardiograms were recorded in 57 patients. Continuous measurements of left ventricular dimension were derived from the echocardiograms by digitization using manual tracing and a computer. Possible errors in the use of a single dimension to assess left ventricular filling were investigated by frame-by-frame analysis of cineangiocardiograms in 37 patients, and the timing of changes in transverse diameter found to correlate closely with those in cavity area. Mitral valve opening, shown as the initial separation of the valve cusps by echocardiography, preceded the 'O' point of the apex cardiogram in all except 3 patients, the 'O' point appearing to correlate more closely with the time of peak rate of outward wall movement. A third heart sound was present in 29 patients, and in 25 of these it occurred later than the peak rate of wall movement (ment interval 51 ms). The end of rapid filling derived from the dimension trace occurred in relation to the third heart sound after a mean interval of 9 ms, with a range from 50 ms before to 80 ms after the third sound. Peak rates of wall movement were similar in patients with and without third heart sounds. The results show that outward left ventricular wall movement begins with a period of acceleration, with peak rates occurring synchronous with the 'O' point of the apex cardiogram and thus with the nadir of the ventricular pressure trace. Outward wall movement becomes less rapid thereafter, so that the rapid filling wave of the apex cardiogram does not reflect the time of rapid filling of the left ventricle. The 'O' point is not related to mitral valve movement nor does the third heart sound bear a consitent relation to any aspect of left ventricular wall movement.
Isoniazid as an inhibitor of primidone metabolism.
Isoniazid inhibited the metabolism of primidone in a patient with focal seizures. The steady-state serum level of primidone rose when the patient received both drugs simultaneoulsy. The serum levels of the primidone metabolites, phenobarbital and phenylethylmalonamide, fell and the rate of metabolism of primidone decreased. The results are similar to those observed when isoniazid is adminstered with diphenylhydantoin.
Proceedings: Early diastolic events in cardiac disorders.
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Letter: Streptokinase and heparin in treatment of pulmonary embolism.
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Haemodynamic findings after homograft replacement of mitral valve.
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Surgery of subvalvular mitral regurgitation.
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Second heart sound in normal subjects.
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Second heart sound in pulmonary hypertension.
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Multiple excimer laser retreatments for scarring and myopic regression following photorefractive keratectomy.
Excimer laser retreatment for scarring with myopic regression following photorefractive keratectomy (PRK) has been reported. We present the 38 month course of a patient who had PRK followed by two retreatments. The patient experienced scarring with myopic regression after an initial PRK with a 5.00 mm ablation zone. These complications recurred 13 months after retreatment with a 5.00 mm ablation zone. Refractive effect, computer-assisted videokeratography measurements, and corneal clarity remained stable 12 months after a second retreatment with a 6.00 mm ablation zone, indicating that retreatment with a larger ablation zone diameter appeared to be an appropriate method for handling this complication.
Inter-sensory facilitation and the diagnosis of functional hearing loss.
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Comparison of 5-mm and 6-mm ablation zones in photorefractive keratectomy for myopia.
BACKGROUND: Variation in ablation zone diameter may alter visual acuity and/or refractive effect in photorefractive keratectomy. Despite theoretical benefits of using a smaller diameter ablation zone, clinical studies suggest that a larger ablation zone may decrease problems associated with photorefractive keratectomy. METHODS: The results of our initial 34 consecutive eyes treated with a 5-mm diameter ablation zone using a Summit Technology ExciMed UV200LA excimer laser were compared retrospectively to our initial 34 consecutive eyes treated with a 6-mm diameter ablation zone using a Summit OmniMed excimer laser. Eyes had a spherical equivalent refraction between -1.00 and -6.00 diopters (D) and astigmatism less than 1.00 D. Patients were followed for a minimum of 6 months. RESULTS: Eyes treated with a 6-mm ablation zone had less hyperopia and a spherical equivalent refraction closer to emmetropia at 1, 2, and 3 months (P = 0.001). Eyes treated with a 6-mm ablation zone had better uncorrected visual acuity at 1 and 2 months (P = 0.001). Less subepithelial haze was noted at 2 months (P = 0.01) and 3 months (P = 0.002) in the 6-mm group. At 6 months postoperatively, 30 of 32 eyes (94%) treated with a 6-mm ablation zone had a spherical equivalent refraction within 0.50 D of emmetropia, and all 32 eyes (100%) were within 1.00 D of emmetropia; in the 5-mm ablation zone group, 28 of 34 eyes (80%) were within 0.50 D and 29 (85%) were within 1.00 D of emmetropia. Patients treated with a 6-mm ablation zone complained less of night halos and had fewer differences between night and day vision. CONCLUSIONS: In this study of myopia of -1.00 D to -6.00 D, eyes treated with a 6-mm ablation zone achieve a more rapid visual recovery with less variation in refractive outcome and less adverse effects than those treated with a 5-mm ablation zone.