Search PubMedSearch

Biomedical subjects

G Sundström

Publications and source records attributed to G Sundström.

At least 19 recordsLinked to original sources

[Dementia is not the only mental problem among the elderly. Long-term perspective is important for care].

The entire 1902 and 1903 birthyear cohorts in the catchment area of Dalby Community Health Centre in southern Sweden have been followed with health examinations and interviews every second year since 1969-70. Of the total of 192 subjects, complete data are available for 153. Of 65 subjects surviving at the age of 83, 6 per cent were advanced dementia cases, 11 per cent were in the early stages of dementia, and a further 17 per cent were afflicted with other mental problems requiring help and care. Of those who died before the age of 83, 11 per cent were afflicted with dementia, with a further 4 per cent in the early stages, and 17 per cent had other mental problems. Thus, the overall risk of dementia is at least 16 per cent, but may eventually turn out to be as high as 30 per cent, while those with other forms of mental dysfunction, serious enough to require help in ADL, account for a similar proportion. The annual incidence of dementia is 7.5 per mill (10.6 per mill including those in early stages). The risk of institutionalisation and death was much higher among the dementia victims, most of whom had had little support from the social services, and some none at all, before being institutionalised. Dementia victims came into contact with the medical services much earlier than did mentally healthy patients with other, often vague and more varied symptoms. It is argued in the article that current concern with dementia should not be allowed to divert our attention from the needs, diagnosis and care of the many elderly patients with other mental problems.

Aged

Hepatitis C virus RNA in blood donor sera detected by the polymerase chain reaction: comparison with supplementary hepatitis C antibody assays.

The low specificity of screening ELISAs for antibodies to hepatitis C virus in blood donors has called for confirmatory tests. Two types of supplementary antibody assays are available, recombinant immunoblot assays (RIBA-1 and RIBA-2) and an antibody consumption test referred to as a neutralization assay. Amplification of viral nucleic acid by the polymerase chain reaction (PCR) provides an antibody independent mode of detecting viral infection. We applied reverse transcription-double PCR to detect an HCV 5'-noncoding viral RNA sequence in serum specimens and compared PCR findings with confirmatory antibody tests. This study includes sera from 37 blood donors found positive by the Ortho anti-HCV (C100-3) ELISA out of 14,591 donations. Of the 37 positive sera, 8 were positive by RIBA-1 and 1 further by RIBA-2. Seven of the RIBA positive sera contained HCV RNA by PCR. Among the 8 indeterminate and the 21 negative donor sera by RIBA-1, no PCR positive serum was found. The 37 anti-HCV positive donor sera identified by Ortho ELISA were also tested by Abbott anti-HCV (C100-3) ELISA whereby 22 were positive. Of these 22 sera plus 1 further with ELISA OD just below cutoff, 8 were positive by the "neutralization assay," (Abbott Laboratories, North Chicago, IL, USA) and 6 of these, including the borderline serum, were PCR positive. One of the two neutralizable but PCR negative sera was RIBA positive and the other was indeterminate. However, one ELISA (Abbott Laboratories) positive (OD 1.99) serum was not neutralizable but nevertheless contained HCV RNA by PCR.(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Donors

Antibody to hepatitis-C-virus-related proteins in sera from alanine-aminotransferase-screened blood donors and prospectively studied recipients.

A prospective study of posttransfusion non-A, non-B hepatitis was conducted in Malmö, Sweden, in 1984-1985, in which donors were alanine aminotransferase (ALT) screened but not ALT selected. Among 741 patients studied at 0, 6, and 12 weeks after transfusion, 13 developed non-A, non-B hepatitis, and these were further followed up. Stored sera from the 13 hepatitis patients and their 123 donors were tested for anti-hepatitis C virus (HCV) by ELISA and if positive, analyzed by recombinant immunoblot assay (RIBA). All ALT-elevated blood units (n = 301) and a similar number of ALT-normal units were also tested. Only 4/13 patients with non-A, non-B hepatitis seroconverted to anti-HCV, all with ALT peaks greater than 10 times the upper normal. All seroconversions occurred within 5 months after transfusion and could be confirmed by RIBA. Hepatitis C in recipients occurred both after transfusion of blood that was strongly positive, weakly positive, and/or negative for anti-HCV by ELISA. In donors grouped by ALT levels, the anti-HCV prevalence varied between 0.4 (normal ALT) and 14% (ALT elevated greater than or equal to 2 times). Of the total of 9 donor units positive by ELISA, only 5 were confirmed by RIBA. Of the 5 recipients of the RIBA-positive blood units, 3 went into hepatitis, 1 remained normal at 10.5 weeks, and 1 showed a slight, transient ALT elevation at week 12. The recipients of ELISA-positive but RIBA-negative blood remained healthy.

Alanine Transaminase

Lung function and bronchial reactivity in aluminum potroom workers.

Lung function and bronchial reactivity were measured in 38 aluminum potroom workers with no airway symptoms and in 20 healthy referents (office workers). All of the participants were non-smokers. The magnitude of exposure to airborne dust (alumina) and fluorides was determined. The aluminum potroom workers had obstructive lung function impairment with a significant decrease in expiratory flow and an increase in residual volume. Diffusing capacity was found to be lower than in the referents. No bronchial hyperreactivity was found in the aluminum potroom workers. The exposure to inhaled alumina and particulate and gaseous fluorides in the plant was low, 15-20% of the Swedish exposure limits. The finding of only modest lung function alterations with no bronchial hyperreactivity in the aluminum potroom workers is not consistent with the results of other authors. This discrepancy can probably be explained by the fact that the exposure to inhaled contaminants in the investigated aluminum plant was low.

Adult

Relation between donor transaminase and recipient hepatitis non-A, non-B in Sweden.

The relation between donor alanine aminotransferase (ALT) and recipient post-transfusion hepatitis (PTH) non-A, non-B was studied in patients tested before and 6 and 12 weeks after transfusion. The minimum ALT criterion for PTH was 105 IU/l (greater than 2.5 times the upper normal of 42 IU/l). In 8.8% of donors, ALT was greater than 42 IU/l, and in 2.3% ALT was greater than 63 IU/l, i.e., 1.5 times elevated. PTH non-A, non-B occurred in 14 of 742 recipients. The PTH incidence increased when donor ALT was above 63 IU/l (1.5 vs. 5.6%; p less than 0.05). However, if the confounding factor of volume variations was compensated for, elevated donor ALT and PTH were only statistically linked among recipients less than 70 years (p less than 0.02; Mantel-Haenszel test).

Alanine Transaminase

Prevalence of bronchial asthma among schoolchildren in a Swedish district.

The prevalence of asthma among 10,527 children aged 7-16 years was investigated in 1985. Children were assigned to the asthma group when replies to a questionnaire stated that at least two of four stipulated symptoms had been experienced in the preceding year. A validation study, comprising exploration of medical history, pulmonary auscultation and physiological tests (spirometry and methacholine inhalation challenge) was performed in 73 children. The overall prevalence of asthma was 4%. The most common symptom-inducing factors were physical exertion, upper respiratory tract infection, contact with animals and tobacco smoke. The methacholine test had limited value as a diagnostic aid, being positive in only 25% of children with a clear history of asthma.

Adolescent

Ending one's life in a nursing home: a note on Swedish findings.

Statistics on place of death, validated against longitudinal evidence on the entrance into nursing homes, show the "final" rate of institutionalization to have risen in the decades between 1938 and 1975 in Sweden. In a local study, 15 percent entered a nursing home between the ages of sixty-seven and eighty, which seems representative of national trends. The "final" rate is estimated to be between 22 percent and a maximum of about 40 percent. Currently, the socially and economically deprived dominate in Swedish nursing homes just as they did in the poor house of the past. Yet, rising rates may indicate raised welfare for the poorest in society. Issues concerning who is institutionalized and why appear more important than precise measurement of rates of institutionalization.

Aged

Post-transfusion hepatitis type non-A, non-B in southern Sweden: occurrence and clinical significance.

Two prospective studies of the occurrence and clinical significance of post-transfusion hepatitis non-A, non-B were performed in Malmö, Sweden. In both studies, patients of a broad clinical spectrum were followed up 6 and 12 weeks after transfusion. In a 7 week study from 1983, hepatitis non-A, non-B occurred in 9/173 transfused patients (5.2%) versus 1/203 untransfused controls (0.5%) (p less than 0.01). In a 6 month study from 1984-85, the incidence of hepatitis non-A, non-B had declined to 2.4% (18/739 transfused patients). The mean number of transfused units was about 5 in both studies and most patients had subclinical disease. Despite similar transfusion volumes to patients above or below 70 years of age, hepatitis non-A, non-B was predominantly seen among patients less than 70 years. In the 1984-85 study, hepatitis non-A, non-B incidence was 1.2% in recipients greater than or equal to 70 years, 3.4% in recipients less than 70 years and 4.5% in recipients less than 40 years. One year after the initial hepatitis non-A, non-B episode, 4/18 patients (22%) had biochemical signs of chronic hepatitis.

Age Factors

The use of the bivalve Mytilus edulis as a test organism for bioconcentration studies. II. The bioconcentration of two 14C-labeled chlorinated paraffins.

The bioconcentration of two 14C-labeled chlorinated paraffins (CP) has been studied in a flow-through test system using the common mussel Mytilus edulis. Both CPs showed a rapid uptake rate and the CP with C16 carbon chain and 34% chlorination had a bioconcentration factor (BCF) of about 7000 (fresh weight). The CP with a C12 carbon chain and 69% chlorination had a very high BCF of almost 140,000 which on a lipid weight basis corresponds to a BCF of around 8,000,000. The C12-CP showed a slow depuration rate in analogy with what has been observed earlier in fish. Radioactivity was recovered from both the fat and protein fractions after exposure to the C12-CP with a level in the protein of about two orders of magnitude lower than in the fat. It is concluded that studies with CPs so far reported indicate that short carbon chain/high chlorinated chlorinated paraffins are strongly bioaccumulating and persistent chemicals.

Animals

Chlorinated phenoxyacetic acid derivatives and tetrachlorodibenzo-p-dioxin in foliage after application of 2,4,5-trichlorophenoxyacetic acid esters.

Six reforestation areas were sprayed with 2,4,5-T esters. Leaf samples from the areas were analyzed for the esters, tetrachlorodioxin, and dehalogenated phenoxyacetic acid esters. Tetrachlorodioxin was found in one leaf sample only, but the level found, relative to the amount of 2,4,5-T ester found, was lower than in the formulation material used in the study. The concentration of the dichlorophenoxyacetic acid esters present in several leaf samples was greater, relative to the 2,4,5-T ester, which indicated a photochemical breakdown of the 2,4,5-T in the environment.

2,4,5-Trichlorophenoxyacetic Acid

Metabolism of chlorodiphenyl ethers and Irgasan DP 300.

1. In the rat chlorodiphenyl ethers are metabolized via two routes. The predominant reaction is aromatic hydroxylation; scission of the ether bond is a minor metabolic process. 2. In all cases, primary hydroxylation takes place ortho and meta to the ether bond. Ortho-hydroxylation leads to the formation of 'predioxins' in cases where the parent compounds contain a chlorine atom in one of the ortho positions in the second ring. 3. 5-Chloro-2-(2,4--dichlorophenoxy)phenol (Irgasan DP 300), a compound that meets the structural requirements of a predioxin, did not yield chlorodibenzo-p-dioxins or hydroxylated derivatives thereof. 4. Irgasan DP 300 is excreted unchanged in faeces and urine (partly conjugated) but is also hydroxylated to five different monohydroxy metabolites which were found in urine; three of these were also present in faeces. As a result of scission of the ether bond 2,4-dichlorophenol occurred in urine and faeces, and 4-chlorocatechol in urine. 5. Neither in the case of Irgasan DP 300, nor in that of chlorodiphenyl ethers with an ortho chlorine atom, could metabolic cyclization to chlorodibenzofurans or their hydroxylated derivatives be detected.

Adipose Tissue

Esophageal manometry in pregnant and nonpregnant women.

Esophageal and gastric tone was recorded in six pregnant and six nonpregnant women by means of a new technique for intraluminal pressure recordings. The recordings were performed in supine and standing positions, at rest, and during swallowing of saliva or water. It was found that the pregnant women had lower intraesophageal pressures but higher intragastric pressures compared to the nonpregnant women. In one of the pregnant women a negative pressure situation was recorded between the stomach and lower esophagus. This patient also complained of severe heartburn when she was lying down. Gastroesophageal reflux seems to be aggravated in pregnant women since esophageal peristalsis in these patients has lower wave speed and lower amplitude compared to nonpregnant women.

Adult

Lateral-hole catheters compared with shielded-hole catheter systems in oesophageal manometry.

Water-filled catheters with lateral holes in the distal ends are frequently used in oesophageal manometry. However, the outward position of the recording holes makes mucosal interference a possible risk. A pilot study of oesophageal manometry was performed in five healthy volunteers comparing a conventional lateral-hole catheter with the orifices directed to the centre of the catheter bundle, protected from the mucosa. The centre-hole catheter curves showed a lower resting pressure in the upper oesophageal sphincter (UOS) showed a lower resting pressure in the upper oesophageal sphincter (UOS) and a more rapid decline of the UOS peristaltic wave. The motility curves of the oesophageal body were identical with both catheters.

Adult

Lung function studies in asymptomatic individuals with moderately (Pi SZ) and severely (Pi Z) reduced levels of alpha1-antitrypsin.

Extensive physiological evaluation of lung function were conducted in two groups of asymptomatic individuals with deficiencies of alpha1-antitrypsin: seven subjects with phenotype Pi SZ and six subjects with phenotype Pi Z. Four symptomatic individuals of Pi Z type were also investigated. The asymptomatic individuals of both SZ and Z phenotypes revealed reduction of elastic recoil, hypoventilation and hypoperfusion of the lung bases with increased closing and nitogen wash-out volumes. No signs of bronchial obstruction were observed. The asymptomatic Pi SZ subjects revealed as many signs of subclinical disease as did the asymptomatic Pi Z subjects. These data suggest that Pi SZ subjects are at increased risk of emphysema similar to Pi Z subjects.

Adult

Environmental chemistry of substitutes for polychlorinated biphenyls. I. Composition and properties of an alkylchlorobiphenyl product.

The composition of a technical alkylchlorobiphenyl mixture, proposed as a substitute for polychlorinated biphenyls, has been investigated by spectral and chromatographic methods. Gas-liquid chromatography-mass spectrometry revealed the presence of a large number of biphenyls substituted with 2-3 chlorine atoms and 0-4 isopropyl groups. The mixture was dechlorinated as a first step toward structure elucidation of the individual components. The behavior of the alkylchlorobiphenyls during analytical cleanup steps such as thin layer chromatography and chromic acid oxidation was also investigated.

Alkylation

Influence of body position on pulmonary diffusing capacity in yound and old men.

Steady-state diffusing capacity (DLCOSS2), studied in healthy nonsmokers, was significantly higher in five old men when seated than when supine, but was unchanged in five young men. However, "corrected" for the increased ventilation, it decreased in the young--but not in the old--when erect compared with when supine. The change of DLCOSS2 in the young during the first 20 min when seated was related to a change of the fractional dead space ventilation (VD/VT)mThe old showed less venous admixture when seated than when supine, whereas VD/VT and regional ventilation-perfusion index of the lung bases was the same in both positions. The decrease in venous admixture was probably due to the closing capacity (CC) being less than the functional residual capacity (FRC) when seated. The elimination of closed off regions when seated made more pulmonary capillaries available for diffusion.

Adult