The present data relate the studies of TSH and Prolactin secretion in response to TRH (500 microgram, IV) in Cushing's syndrome. Twenty-five patients were explored before treatment (4 adrenal carcinoma, 5 adrenal adenoma, 2 Cushing's diseases with patent pituitary tumor, 14 Cushing's diseases without patent pituitary tumor). Thirteen of the twenty-five patients were studied after treatment of their hypercorticism. Identical studies were realized in 5 patients receiving oral corticotherapy. The results, compared with those obtained in normal subjects are: the TSH basal values are normal or low. The TSH response is lower in untreated Cushing's disease (p2a : 0,01) and normal or low in other cases. The Prolactin basal values are significantly higher in untreated adrenal carcinoma (p2a : 0,05) and in Nelson's syndrome (p2a : 0,01), normal or high in other cases. The prolactin response before treatment is significantly higher in male Cushing's diseases (p2a : 0,05), high or normal in other cases, and unchanged in Nelson's syndrome. Those abnormalities of basal values and/or responses of TSH and Prolactin do not seem sufficiently discriminant of the etiology of Cushing's syndrome especially tumoral causes, in particular pituitary causes. They seem connected to hypercorticism because of the treatment of the last one corrects them. But other factors must be concerned in the Nelson's syndrome case.

Adolescent↗

PubMedDate not supplied

[Long term results of the surgical treatment of acromegaly. Longitudinal study of a series of 68 patients (author's transl)].

In order to evaluate treatment of acromegaly, a 5-year study was undertaken on 68 acromegalics, selected from a series of 155 cases, treated by surgery alone (31 cases) or by combined surgery and radiotherapy (37 cases). Immediate return to normal of STH levels in the post-operatoire period is rare (7%) and the clinical improvement observed in most instances seems to be explained by the relative fall in STH that is usually found. Blood volume appears to be the best metabolic parameter of STH levels. Rapid return to normal of STH levels in the post-operative period is a good pronostic sign, but the authors emphasize that STH secretion can vary in the same patient after surgery alone or after combined surgery and radiotherapy. The pituitary insufficiency observed in 35% of cases is more frequent after limited surgical excision followed by radiotherapy or after wide excision alone. In 70% of cases, patients with pituitary insufficiency retain raised STH levels.

Acromegaly↗

PubMedDate not supplied

[Physiology and physiopathology of human prolactin; therapeutic applications].

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Animals↗

PubMedDate not supplied

[Effect of dimethicone on pharmacokinetics and pharmacodynamics of ethyl biscoumacetate].

The influence of dimeticone (Gel de Polysilane Midy) on the pharmacokinetics and pharmacodynamics of oral ethyl biscoumacetate was studied in 6 healthy volunteers in a randomised single dose, two-way cross-over study. Each volunteer received at one week interval a single dose (300 mg) of ethyl biscoumacetate, either alone or with dimeticone. Ethyl biscoumacetate levels were measured in plasma for 24 hours. Pharmacodynamic parameters were measured for 96 hours. Ethyl biscoumacetate peak concentration was significantly higher when administered with dimeticone (40.3 +/- 25.3 mg/l vs 31.0 +/- 25.7 mg/l; p = 0.031), without significant change in the area under curve. Other pharmacokinetic and pharmacodynamic parameters did not differ significantly. The slight increase of the ethyl biscoumacetate bioavailability with dimeticone in repeated dosing might have pharmacodynamic consequence; a clinical trial should address this question.

Adult↗

PubMedDate not supplied

[Study of the action of bromocriptine in hyperprolactinemic states. Results of a cooperative trial in 135 patients].

The therapeutic activity of bromocriptine mesilate (CB 154) was studied in a coooperative trial over a period of three months and using the same protocol in eleven different centres. 126 women and 9 men were studied. All had hyperprolactinaemia associated either with gonadal insufficiency-amenorrhoea/galactorrhoea syndrome (102 cases), isolated amenorrhoea (8 cases), impotence (6 cases), or to galactorrhoea with in certain men gynaecomastia. 32 patients had previously undergone removal of a pituitary adenoma, but had a normal response to the administration of LH-RH. Of the 106 untreated patients, only 36 had tumour-like deformities of the sella turcica. Under the effects of treatment, blood prolactin levels fell in all cases exception 4 and returned to normal in 66% of patients. The average value fell from 197 +/- 19 to 36.8 +/- 3.4 ng/ml (p less than 0.001). Spontaneous and provoked galactorrhoea regressed in 100% and 75% of cases respectively. Ovarian function reappeared in 89.4% of cases, with 32 pregnancies occurring during the 3 months period. Gynaecomastia and impotence responded in approximately half the men. The effectiveness of treatment was independent of the duration of the disorder (ranging from a few months to five years), the initial prolactin level and the radiological state of the sella turcica. Tolerance was satisfactory apart from transient problems (essentially digestive) occurring during the first days of treatment. In case of pregnancy, careful repeated studies of the sella turcica and visual fields are needed in order to detect possible growth of underlying pituitary adenomas or micro-adenomas.

Amenorrhea↗